Role of Hypotaurine in Protection against UVA‐Induced Damage in Keratinocytes

Abstract

Photoageing and skin cancer are major causes of morbidity and are a high cost to society. Interest in the development of photoprotective agents for inclusion in topical cosmetic and sunscreen products is profound. Recently, amino acids with a sulfinic group, notably hypotaurine, have been included as ingredients in cosmetic preparations. However, the mechanism of action of hypotaurine as a possible anti‐aging agent is unknown, despite its use as a free radical scavenger. To address this issue, we investigated hypotaurine uptake in a human keratinocyte model and examined its effect on UVR‐induced cytotoxicity. Hypotaurine was taken up by keratinocytes in a time‐ and concentration‐dependent manner, with levels remaining significantly above baseline 48 h after washout. A cytoprotective effect of pre‐incubation with 2.5–5 mMhypotaurine was shown as indicated by increased cell viability when keratinocytes were irradiated with UVA at 5 or 10 Jcm‐2, with the level of hypotaurine also significantly reduced. These findings indicate a potential cytoprotective effect of hypotaurine against the deleterious effects of UVA irradiation. This provides support for further studies to evaluate the potential photoprotective benefits of hypotaurine supplementation of topical cosmetic and sunscreen products.

Protective effects of 2-aminoethylthiosulfuric acid and structurally analogous organosulfur compounds against ionizing radiation

“…(11)(12)(13)(14)(15) HTAU protects cells from H 2 O 2 induced damage and ultraviolet light (UV) irradiation. (16,17) These reports support the potential for TTAU and HTAU protection against ionizing radiation damage.…”

S-allyl cysteine and Taurine attenuate diabetic nephropathy in rats via the inhibition of oxidative stress and recovering histopathological changes

“…Allium plants such as garlic ( Allium sativum , Liliaceae) produce S-allyl cysteine (SAC; S-hydrocarbyl-L-cysteine) (Figure 1) (NCBI, 2022a), an organosulfur amino acid (Aziz, Ramalingam, Latip, & Zainalabidin, 2021). Aged garlic extract contains more durable and bioavailable water-soluble organosulfur components like S-allylmercapto-L-cysteine (SAMC), SAC, ajoene, alliin and allicin (Asdaq et al ., 2021; Baseggio Conrado, Fanelli, McGuire, & Ibbotson, 2021; Rais, Ved, Ahmad, & Parveen, 2021). In several studies, SAC (a phytochemical) has been documented to have antioxidant (Ruiz-Sanchez, Pedraza-Chaverri, Medina-Campos, Maldonado, & Rojas, 2020), antihepatotoxic (Anandasadagopan et al ., 2017), neurotrophic (Tobon-Velasco et al ., 2012) and anticancer (Xu et al ., 2018) activities.…”

Peptide‐pro complex serum: Investigating effects on aged skin

“…Baseggio Conrado et al examined the role of hypotaurine, an amino acid with a sulfur group, in the in vitro protection against UVA‐induced damage. They concluded that this sulfur amino acid could be an effective photoprotective ingredient in cosmetic and sunscreen formulations 8 . Hameury et al investigated a gel composed of ingredients from marine and maritime origins.…”

“…They concluded that this sulfur amino acid could be an effective photoprotective ingredient in cosmetic and sunscreen formulations. 8 Hameury et al investigated a gel composed of ingredients from marine and maritime origins. They concluded that these ingredients may prevent the visible signs of skin aging and may help keep the dermis and epidermis healthy.…”