Role of <i>Helicobacter pylori</i> infection in the manifestation of old age‐related diseases

Zendehdel, Abolfazl; Roham, Maryam

doi:10.1002/mgg3.1157

Cited by 23 publications

(21 citation statements)

References 111 publications

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“…A meta-analysis suggested that H. pylori infections might be associated with PD risk (Shen et al, 2017). When compared to H. pylori-negative PD patients, H. pyloriinfected PD patients present with worse motor dysfunction and they display a 12-fold increase in mortality rate (McGee et al, 2018;Zendehdel and Roham, 2020). Additionally, H. pylori may affect the absorption of levodopa, and the eradication of H. pylori in PD patients has been shown to improve motor function and levodopa absorption compared with those in PD patients in whom H. pylori were not eradicated (McGee et al, 2018).…”

Section: Altered Gastrointestinal Microbiota Composition In Pdmentioning

confidence: 99%

Review: The Role of Intestinal Dysbiosis in Parkinson’s Disease

Huang

Liao

Liu

et al. 2021

Front. Cell. Infect. Microbiol.

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Several studies have highlighted the roles played by the gut microbiome in central nervous system diseases. Clinical symptoms and neuropathology have suggested that Parkinson’s disease may originate in the gut, which is home to approximately 100 trillion microbes. Alterations in the gastrointestinal microbiota populations may promote the development and progression of Parkinson’s disease. Here, we reviewed existing studies that have explored the role of intestinal dysbiosis in Parkinson’s disease, focusing on the roles of microbiota, their metabolites, and components in inflammation, barrier failure, microglial activation, and α-synuclein pathology. We conclude that there are intestinal dysbiosis in Parkinson’s disease. Intestinal dysbiosis is likely involved in the pathogenesis of Parkinson’s disease through mechanisms that include barrier destruction, inflammation and oxidative stress, decreased dopamine production, and molecular mimicry. Additional studies remain necessary to explore and verify the mechanisms through which dysbiosis may cause or promote Parkinson’s disease. Preclinical studies have shown that gastrointestinal microbial therapy may represent an effective and novel treatment for Parkinson’s disease; however, more studies, especially clinical studies, are necessary to explore the curative effects of microbial therapy in Parkinson’s disease.

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Section: Altered Gastrointestinal Microbiota Composition In Pdmentioning

confidence: 99%

Review: The Role of Intestinal Dysbiosis in Parkinson’s Disease

Huang

Liao

Liu

et al. 2021

Front. Cell. Infect. Microbiol.

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“…In recent years numerous reviews focused on this topic [ 11 , 13 , 14 , 68 , 79 , 331 , 332 , 333 , 334 , 335 , 336 , 337 , 338 , 339 , 340 , 341 , 342 , 343 , 344 , 345 , 346 ]. Most of HPI–linked extra-gastroduodenal chronic diseases and disorders as well as treatments used for are known to increase risk of OP, falls and OFs, especially in the elderly [ 317 , 347 , 348 , 349 ]. More than 80% of patients with a clinical vertebral or non-vertebral fracture suffer at least one chronic disease, and in 65.5% of these patients at least one bone- and/or fall-related RF was found [ 350 ].…”

Section: Hpi-associated Chronic Extra-gastroduodenal Diseases Medmentioning

confidence: 99%

Helicobacter pylori Related Diseases and Osteoporotic Fractures (Narrative Review)

Fisher

Smith

2020

JCM

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Osteoporosis (OP) and osteoporotic fractures (OFs) are common multifactorial and heterogenic disorders of increasing incidence. Helicobacter pylori (H.p.) colonizes the stomach approximately in half of the world’s population, causes gastroduodenal diseases and is prevalent in numerous extra-digestive diseases known to be associated with OP/OF. The studies regarding relationship between H.p. infection (HPI) and OP/OFs are inconsistent. The current review summarizes the relevant literature on the potential role of HPI in OP, falls and OFs and highlights the reasons for controversies in the publications. In the first section, after a brief overview of HPI biological features, we analyze the studies evaluating the association of HPI and bone status. The second part includes data on the prevalence of OP/OFs in HPI-induced gastroduodenal diseases (peptic ulcer, chronic/atrophic gastritis and cancer) and the effects of acid-suppressive drugs. In the next section, we discuss the possible contribution of HPI-associated extra-digestive diseases and medications to OP/OF, focusing on conditions affecting both bone homeostasis and predisposing to falls. In the last section, we describe clinical implications of accumulated data on HPI as a co-factor of OP/OF and present a feasible five-step algorithm for OP/OF risk assessment and management in regard to HPI, emphasizing the importance of an integrative (but differentiated) holistic approach. Increased awareness about the consequences of HPI linked to OP/OF can aid early detection and management. Further research on the HPI–OP/OF relationship is needed to close current knowledge gaps and improve clinical management of both OP/OF and HPI-related disorders.

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“…UTIs occur in 3% to 5% of girls and 1% of boys [ 2 ]. Studies have shown that the prevalence of UTIs is greater than that of bacterial meningitis, bacterial pneumonia, middle ear infection and bacteraemia [ 3 ]. During infancy, 5% of febrile girls and 20% of uncircumcised febrile boys present with UTI.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the relationship between vitamin D levels and prevalence of urinary tract infections in children

Sherkatolabbasieh

Firouzi

Shafizadeh

et al. 2020

New Microbes and New Infections

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Urinary tract infection (UTI) is associated with increased health burden among paediatric patients. Vitamin D is known for its immunoregulatory effects, particularly antimicrobial activity. The aim of this study was to determine the relationship between vitamin D levels and UTIs in children referred to a hospital in Khorramabad, Iran. This case–control study was conducted on 258 children aged between 2 and 14 years; 44 children with UTI and 214 healthy children were enrolled. Patients were tested for UTI on the basis of signs and symptoms, and urine culture and analysis. Vitamin D levels were measured in children in both groups. According to the results, the two groups were significantly different in terms of sex (p 0.007). There was no significant difference between the mean vitamin D among the two groups. Vitamin D levels were not related to UTI by multivariate logistic regression. The relationship between the level of vitamin D and the incidence of UTI in children in accordance with age and sex had an odds ratio of 0.99, indicating that for a 1-unit increase in vitamin D, the odds of having a UTI decreased by 1, a correlation which was not statistically significant. According to the findings of this study, no significant correlation was found between UTI and vitamin D levels. However, the prevalence of UTI was higher in girls than boys.

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Role of Helicobacter pylori infection in the manifestation of old age‐related diseases

Cited by 23 publications

References 111 publications

Review: The Role of Intestinal Dysbiosis in Parkinson’s Disease

Review: The Role of Intestinal Dysbiosis in Parkinson’s Disease

Helicobacter pylori Related Diseases and Osteoporotic Fractures (Narrative Review)

Evaluation of the relationship between vitamin D levels and prevalence of urinary tract infections in children

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