Role of<i>p53</i>codon 72 polymorphism in the risk of development of distal gastric cancer

Pérez-Pérez, Guillermo I.; Bosques-Padilla, Francisco; Crosatti, Maria Luisa; Tijerina-Menchaca, Rolando; Garza‐González, Elvira

doi:10.1080/00365520410009456

Cited by 37 publications

(25 citation statements)

References 17 publications

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“…These results are consistent with our, larger, study. By contrast, two studies reported that the Arg/Arg genotype was associated with an increased risk of gastric cancer [16,22], while other studies found no association [20,[23][24][25][26][27]. Although the reason for these inconsistencies is unclear, they may be explained by differences in ethnicity, small numbers of patients, and substantial interindividual variation in the susceptibility to genetic events and tumor development.…”

Section: Discussionmentioning

confidence: 99%

p53 codon 72 polymorphism in patients with gastric and colorectal cancer in a Korean population

et al. 2011

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Background The common p53 codon 72 polymorphism has been investigated as a risk factor for cancer in different populations; however, the results have been inconsistent. This study investigated the risk of developing gastric or colorectal cancer associated with the p53 codon 72 polymorphism in a Korean population. Methods We conducted a large-scale case-control study that included 2,213 gastric cancer patients; 1,829 colorectal cancer patients; and 1,700 healthy controls. Genotyping was performed with real-time polymerase chain reaction (PCR), using a TaqMan single-nucleotide polymorphism (SNP) genotyping assay. Results The frequencies of Arg/Arg, Arg/Pro, and Pro/ Pro genotypes of the p53 codon 72 polymorphism were 43.3, 42.0, and 13.0% in the gastric cancer patients; 40.5, 45.0, and 14.0% in the colorectal cancer patients; and 43.2, 45.6, and 11.2% in the controls, respectively. The Pro/Pro genotype was associated with an increased risk of gastric [age-and sex-adjusted odds ratio (OR) = 1.25, 95% confidence interval (CI) = 1.01-1.56, P = 0.04] and colorectal cancer (OR = 1.36, 95% CI = 1.07-1.72, P = 0.01). There were no significant interactions between the p53 codon 72 polymorphism and smoking or drinking. Conclusions Our results suggest that the Pro/Pro genotype is associated with modest increases in the risks of gastric cancer and colorectal cancer in a Korean population.

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Section: Discussionmentioning

confidence: 99%

p53 codon 72 polymorphism in patients with gastric and colorectal cancer in a Korean population

et al. 2011

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“…There are two histologically distinct GC: the diffuse-type and intestinal-type. When GC was not classified by tissue type, the Arg/Arg genotype of p53 codon 72 was found to be related to the development of distal GC in the Mexican population (Pérez-Pérez et al, 2005) and the Arg allele with non-cardias GC in the Chinese (Shen et al, 2004). In addition, patients with cardiac cancer had a significantly higher frequency of the Arg/Arg genotype than chronic gastritis, DU and non-cardiac cancer in the UK (Zhang et al, 2004).…”

Section: Discussionmentioning

confidence: 91%

“…Such changes may contribute to tumor progression and a poor prognosis (Katkoori et al, 2009). Taking into consideration of the extensive role of p53 in GC, hence, to derive a more precise estimation of the association of Arg72Pro polymorphism between p53 gene and GC, we performed a meta-analysis of all eligible case-control studies (Hamajima et al, 2002;Hiyama et al, 2002;Zhang et al, 2003;Shen et al, 2004;Wu et al, 2004;Lai et al, 2005;Mu et al, 2005;Pérez-Pérez et al, 2005;Sul et al, 2006;Yi et al, 2006;Capelláet al, 2008;De Feo et al, 2009;Gomes de Souza et al, 2009;Kim et al, 2010;Mojtahedi et al, 2010;Shirai et al, 2010;Ihsan et al, 2011;Song et al, 2011;Zhu et al, 2012).…”

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confidence: 99%

Updated Meta-analysis of the TP53 Arg72Pro Polymorphism and Gastric Cancer Risk

Xiang

Mi²,

Li³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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“…В литературе описаны ассоциации изучаемого полиморфизма гена ТР53 с разными морфологическими вариантами РЖ. Gao et al показали, что носительство аллеля 72Pro гена ТР53 ассоциировано с повышенным риском формирования диффузного типа РЖ среди азиатов, но пониженным риском развития интестинального типа РЖ среди европеоидов [35], что подтверж-дается метаанализом, проведённым B. Xiang et al [28]. В настоящей работе не обнаружено связи генотипов ТР53 с риском развития диффузного или интестинального типов рака желудка.…”

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Polymorphism of the Tp53 Gene in Patients With Gastric Cancer in Prospective and Clinical Case-Control Studies

et al. 2018

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Background.A functionally significant TP53Arg72Pro polymorphism can contribute to the development of gastric cancer (GC).The aim:to study the associations of genotypes and alleles of the TP53Arg72Pro 4 polymorphism with GC and biomarkers of gastric ucosal atrophy in population-based prospective and case-control clinical trials among the population of Siberia.Material and methods.As a part of the epidemiological study, data of the international multicenter HAPIEE project for 2003–05, based on a population sample of residents of Novosibirsk city (serum and DNA samples) and data of the population-based registry of GC (2012) were compared. Gastric cancer patients were matched by age and sex to HAPIEE population controls. A total of 156 serum samples (GC – 52, control – 104) and 146 DNA samples (GC – 50, control – 96) were available for prospective analysis. DNA samples from 80 gastric cancer patients (45 men and 35 women, mean age 61.0 ± 13.4 years) and from 87 age-and sex-matched controls were analyzed. DNA samples from venous blood were genotyped according to standard methods. Serum samples were tested using diagnostic kit for enzyme-linked immunosorbent assays to determine the levels of pepsinogen I (PGI), PGII, PGI/PGII ratio, gastrin-17 and IgG antibodies to H. pylori.Results.No differences in genotype and allele frequencies of the TP53 gene between the case group and the control group were found. A decreased frequency of the Pro allele in female gastric cancer patients compared with controls indicated that the Pro allele is protective against the development of gastric cancer, but this effect was not observed in male patients. No associations of TP53 genotypes with the risk of diffuse or intestinal gastric cancer, as well as with the age and sex of patients were found. A high frequency of genotypes with the Pro allele in patients with stage III–IV gastric cancer indicated the relationship between Arg/Pro TR53 and tumor progression, in particular, the contribution of the minor Pro allele to the unfavorable prognosis. A prospective study showed high risk of reducing the level of pepsinogen for assessing predisposition to gastric cancer.Conclusion.Two case-control studies (population and clinical) conducted in the Western Siberia found no relationship between the TP53Arg72Pro polymorphism and the risk of gastric cancer. However, the TP53 genotype with a rare Pro allele was associated with atrophic gastritis and severity of gastric cancer.

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Role ofp53codon 72 polymorphism in the risk of development of distal gastric cancer

Abstract: The results of this study suggest that the carriage of the Arg/Arg genotype could be associated with the development of distal GC in this Mexican population.

Cited by 37 publications

References 17 publications

p53 codon 72 polymorphism in patients with gastric and colorectal cancer in a Korean population

p53 codon 72 polymorphism in patients with gastric and colorectal cancer in a Korean population

Updated Meta-analysis of the TP53 Arg72Pro Polymorphism and Gastric Cancer Risk

Polymorphism of the Tp53 Gene in Patients With Gastric Cancer in Prospective and Clinical Case-Control Studies

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