Role ofPorphyromonas gingivalisHmuY in Immunopathogenesis of Chronic Periodontitis

Abstract

Periodontitis is a multifactorial disease, with participation of bacterial, environmental, and host factors. It results from synergistic and dysbiotic multispecies microorganisms, critical “keystone pathogens,” affecting the whole bacterial community. The purpose of this study was to review the role of Porphyromonas gingivalis in the immunopathogenesis of chronic periodontitis, with special attention paid to HmuY. The host response during periodontitis involves the innate and adaptive immune system, leading to chronic inflammation and progressive destruction of tooth-supporting tissues. In this proinflammatory process, the ability of P. gingivalis to evade the host immune response and access nutrients in the microenvironment is directly related to its survival, proliferation, and infection. Furthermore, heme is an essential nutrient for development of these bacteria, and HmuY is responsible for its capture from host heme-binding proteins. The inflammatory potential of P. gingivalis HmuY has been shown, including induction of high levels of proinflammatory cytokines and CCL2, decreased levels of IL-8, and increased levels of anti-HmuY IgG and IgG1 antibodies in individuals with chronic periodontitis. Therefore, the HmuY protein might be a promising target for therapeutic strategies and for development of diagnostic methods in chronic periodontitis, especially in the case of patients with chronic periodontitis not responding to treatment, monitoring, and maintenance therapy.

Cuidados Paliativos E Odontologia

“…A proteína HmuY constitui uma importante ferramenta para aquisição de nutrientes pela bactéria, principalmente em situações onde há limitação de ferro/ hemina disponível no meio (OLCZAK, SIUDEJA e OLCZAC, 2006). Ela pode ser encontrada na superfície bacteriana e ser liberada no meio extracelular, como dímero ou em vesículas, o que amplia sua capacidade de induzir reposta no hospedeiro, além de ser uma proteína resistente à ação de enzimas proteolíticas (CARVALHO-FILHO et al, 2016). Já foi relatado que HmuY pode estimular a produção de citocinas IL-1β, IL-10, IL-6 e inibir IL-8 em células mononucleares de sangue periférico em indivíduos com periodontite (TRINDADE et al, 2011;TRINDADE et al, 2013).…”

A Novel Small Molecule, 1,3-di-m-tolyl-urea, Inhibits and Disrupts Multispecies Oral Biofilms

“…P. gingivalis plays an important role in tissue breakdown by modulating the host immune response and invading epithelial cells via the production of several proteases (gingipains) [ 10 ]. This results in the release of collagen and heme, which are used as nutritional sources for further growth and biofilm development [ 1 , 11 ]. There are several other mechanisms by which P. gingivalis modulates and escapes from the host immune system.…”

ALELOPATIA DE EXTRATOS AQUOSOS DE Eragrostis lugens Nees. NA GERMINAÇÃO E CRESCIMENTO INICIAL DE Oryza sativa L

“…Assim, tal abordagem pode ser utilizada para os fatores de virulência, buscando alvos terapêuticos (CUENO et al, 2014) e buscando compreender sua interação com o sistema imune do hospedeiro. As gingipaínas, o sideróforo HmuY e a neuraminidase são exemplos de proteínas sintetizadas por P. gingivalis, as quais são consideradas fatores de virulência, contribuindo para sua capacidade de induzir a periodontite (GUO et al, 2010;CARVALHO-FILHO et al 2016;DASHPER et al, 2017). (NAITO et al, 2008;BITTNER-EDDY et al, 2013;LI et al, 2016;LEONE et al, 2018) (SOCRANSKY et al, 1998;XIMÉNEZ-FYVIE, HAFFAJEE & SOCRANSKY, 2000).…”