Role of TNFSF15 in the intestinal inflammatory response

Kadiyska, Tanya; Tourtourikov, Ivan; Popmihaylova, Ana-Maria; Kadian, Hilda; Chavoushian, Ani

doi:10.4291/wjgp.v9.i4.73

Cited by 11 publications

(9 citation statements)

References 44 publications

(61 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…32 rs6478108 at the TNFSF15 locus was also found to be associated with leprosy in logistic regression analysis, the TNFSF15 gene is involved in mediating the switch from Th1 cells to Th2 cells, and plays an important role in the control of both pro-and anti-inflammatory cytokines. 33,34 GMDR was performed as a genetic risk model to determine the influence of the combination of SNPs along with confounding factors. 24,35 In our present study, GMDR was used to study the extensive gene-gene interactions of leprosy along with the adjustment of confounding factors.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Single-Nucleotide Polymorphisms in Genes Predisposing to Leprosy in Leprosy Household Contacts in Zhejiang Province, China

Shen

Long

Kong

et al. 2020

PGPM

View full text Add to dashboard Cite

Purpose Genome-wide association studies (GWAS) have identified multiple genetic variants associated with leprosy. To investigate the single and combined associations between single-nucleotide polymorphisms (SNPs) and the development of leprosy, we therefore performed generalized multi-analytical (GMDR) analysis in Chinese leprosy household contacts and constructed a risk prediction model. Patients and Methods This case–control study included 229 leprosy cases and 233 healthy household contacts in Zhejiang province, China. Participants were genotyped for 17 polymorphisms selected from GWAS. The Pearson χ 2 test, logistic regression and GMDR analysis were performed to investigate gene–gene interactions and construct a risk prediction model for leprosy. Results The genotype and the allele distributions of rs142179458, rs2275606, rs663743 and rs73058713 were significantly different between patients and controls. rs2275606, rs6478108, rs663743 and rs73058713 showed an association after adjusting for sex and age in the logistic regression. A five-way interaction model consisting of rs2058660, rs2275606, rs4720118, rs6478108 and rs780668 was chosen as the optimal model for determining leprosy susceptibility. The model classified 237 (51.3%) into the low-risk group and 225 (48.7%) individuals into the high-risk group. The area under the curve (AUC) of this model was 0.757 (95% CI: 0.712–0.803), and the odds ratio for leprosy between the high- and low-risk groups was 9.733 (95% CI: 6.384–14.960; P <0.001). The sensitivity and specificity of the model were observed to be 74.7% and 76.8%, respectively. Conclusion Our results suggest that rs2058660, rs2275606, rs4720118, rs6478108 and rs780668, five SNPs with a signiﬁcant sole effect on leprosy, interact to confer a higher risk for the disease in leprosy household contacts (HHCs).

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Single-Nucleotide Polymorphisms in Genes Predisposing to Leprosy in Leprosy Household Contacts in Zhejiang Province, China

Shen

Long

Kong

et al. 2020

PGPM

View full text Add to dashboard Cite

show abstract

“…An association of this gene with IBS was unearthed in an early study (24), and this finding was verified in independent cohorts (20,25,26). Altogether, the association of TNFSF15 with IBS is worth further investigation, especially as this gene has involvement in the intestinal inflammatory response (27).…”

Section: Genetic Factorsmentioning

confidence: 90%

Uncovering the pathophysiology of irritable bowel syndrome by exploring the gut-brain axis: a narrative review

Tang¹,

Jiang²,

Wang³

et al. 2021

Ann Transl Med

View full text Add to dashboard Cite

Objective: To improve the pathophysiological understanding of irritable bowel syndrome (IBS) by exploring the gut-brain axis.Background: Disorders of gut-brain interaction (DGBIs) are gastrointestinal (GI) disorders in which alterations in bowel functions occur. IBS, which is one of the most studied DGBIs, is linked with abdominal distress or pain without obvious structural or biochemical anomalies. Methods:The etiology of IBS has not been clearly described but is known to be multifactorial, involving GI motility changes, post-infectious reactivity, visceral hypersensitivity, gut-brain interactions, microbiota dysbiosis, small intestinal bacterial overgrowth, food sensitivity, carbohydrate malabsorption, and intestinal inflammation.Conclusions: One of the main features of IBS is the occurrence of structural and functional disruptions in the gut-brain axis, which alter reflective and perceptual nervous system reactions. Herein, we provide a brief summary of this topic. Furthermore, we discuss animal models, which are important in the study of IBS, especially as it is linked with stressors. These animal models cannot fully represent the human disease but serve as important tools for understanding this complicated disorder. In the future, technologies, such as organ-on-a-chip models and metabolomics, will provide novel information regarding the pathophysiology of IBS, which will play an important role in treatment development. Finally, we take a brief glance at how acupuncture treatments may hold potential for patients with IBS.

show abstract

“…The tumor necrosis factor superfamily member 15 (TNFSF15), encoding the protein of the same name, is associated with inflammatory pain in patients with IBS [16][17][18]. TNFSF15 is expressed in epithelial cells, including those that line the intestinal walls [19]. The genotype of SNP TNFSF15 rs4263839 (located at 9q32) correlated with TNFSF15 mRNA expression was associated with an increased risk of IBS [15,16,20].…”

Section: Introductionmentioning

confidence: 99%

The Associations of Single Nucleotide Polymorphisms with Risk and Symptoms of Irritable Bowel Syndrome

Zhao

Zhang

Lee

et al. 2022

JPM

View full text Add to dashboard Cite

Although several risk single nucleotide polymorphisms (SNPs) have been found to play an important role in etiology of irritable bowel syndrome (IBS), the findings are inconsistent. A descriptive correlational design was used to analyze the baseline data of a randomized controlled trial including participants with IBS and healthy controls (HC). Pain severity and interference, anxiety, sleep, and fatigue were measured using the Brief Pain Inventory (BPI) and patient-reported outcomes measurement information system (PROMIS). Fisher’s exact test and multivariate linear regression were used to investigate the associations between IBS risk alleles and IBS symptoms. Participants were predominantly female, white, and had an average age of 21.13 ± 2.42 years. Polymorphisms within TNFSF15 (rs4263839), SLC6A4 5-HTTLPR, HTR3A (rs1062613), and OXTR (rs2254298) were associated with IBS risk, and TNFSF15 (rs4263839), COMT (rs6269), SLC6A4 5-HTTLPR polymorphisms were associated with pain severity. TNFSF15 (rs4263839) and COMT (rs4680; rs4633) genotypes were associated with sleep disturbance, and the ADRA1D SNP rs1556832 was associated with fatigue in both IBS and HC groups. Genotypic differences were associated with IBS risk and symptoms including abdominal pain, sleep disturbance, and fatigue. Further investigation is warranted to reveal the mechanisms by which these genetic variations influence the dynamic nature of IBS symptoms over time.

show abstract

Role of TNFSF15 in the intestinal inflammatory response

Cited by 11 publications

References 44 publications

<p>Single-Nucleotide Polymorphisms in Genes Predisposing to Leprosy in Leprosy Household Contacts in Zhejiang Province, China</p>

<p>Single-Nucleotide Polymorphisms in Genes Predisposing to Leprosy in Leprosy Household Contacts in Zhejiang Province, China</p>

Uncovering the pathophysiology of irritable bowel syndrome by exploring the gut-brain axis: a narrative review

The Associations of Single Nucleotide Polymorphisms with Risk and Symptoms of Irritable Bowel Syndrome

Contact Info

Product

Resources

About