Role of IL-10 and TGF-β1 in local immunosuppression in HPV-associated cervical neoplasia

Torres-Poveda, Kirvis

doi:10.5306/wjco.v5.i4.753

Cited by 119 publications

(110 citation statements)

References 75 publications

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“…Women with persistent HPV16 infection have been observed to have significantly higher Treg frequencies than HPV-negative women [65]. Also, Treg-inducing molecules like TGF-β 1 have been shown to be increased in lesions progressing from LSIL to invasive CC [66, 67]. …”

Section: Discussionmentioning

confidence: 99%

From HPV Infection to Lesion Progression: The Role of HLA Alleles and Host Immunity

et al. 2019

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Persistent high-risk human papillomavirus (HPV) infection has been associated with increased risk for cervical precancerous lesions and cancer. The host’s genetic variability is known to play a role in the development of cervical cancer. The human leukocyte antigen (HLA) genes are highly polymorphic and have shown to be important risk determinants of HPV infection persistence and disease progression. HLA class I and II cell surface molecules regulate the host’s immune system by presenting HPV-derived peptides to T-cells. The activation of T-cell response may vary depending on the HLA allele polymorphism. The engagement of the T-cell receptor with the HPV peptide-HLA complex to create an active costimulatory signal is essential for the activation of the T-cell response. Functional peptide presentation by both HLA class I and II molecules is needed to activate efficient helper and effector T-cell responses in HPV infection recognition and clearance. Some of these HLA risk alleles could also be used as preventive tools in the detection of HPV-induced cervical lesions and cancer. These HLA alleles, together with HPV vaccines, could potentially offer possible solutions for reducing HPV-induced cervical cancer as well as other HPV-related cancers.

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Section: Discussionmentioning

confidence: 99%

From HPV Infection to Lesion Progression: The Role of HLA Alleles and Host Immunity

et al. 2019

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“…TGF-β additionally serves important regulatory functions in CC, as for example, the oncoproteins of HPVs may stimulate TGF-β1 expression in CC cells, which in turn suppresses the host immune surveillance towards CC, and triggers the EMT process, migration and metastasis of CC cells (30)(31)(32)(33). Endogenous TGF-β activity has been reported to limit the expression in of TSLP in intervertebral disc tissue in a steady state by suppressing nuclear factor-κB activation (17).…”

Section: Discussionmentioning

confidence: 99%

Human thymic stromal lymphopoietin promotes the proliferation and invasion of cervical cancer cells by downregulating microRNA‑132 expression

et al. 2017

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Abstract. Thymic stromal lymphopoietin (TSLP), produced by cervical cancer (CC) cells, promotes angiogenesis, and the recruitment and functional regulation of eosinophils. It has been reported that microRNA (miR)-132 is aberrantly decreased in CC tissues. However, the function and mechanism of TSLP on the biological behaviors of CC cells is largely unknown. The aim of the present study was to investigate the effect of TSLP on the expression of miR-132 and the proliferation and invasion in vitro of CC cell lines, namely, HeLa and SiHa cells. The transcrpitional level of miR-132 was analyzed using reverse transcription-quantitative polymerase chaon reaction. The proliferation, invasion, and the expression of proliferation and invasion-related molecules in HeLa and SiHa cells in vitro were evaluated using bromodeoxyuridine cell proliferation, Matrigel invasion assays, flow cytometry and ELISA, respectively. Here, it was revealed that recombinant human TSLP (rhTSLP) downregulated the expression levels of miR-132 in HeLa and SiHa cells, and by contrast, the neutralizing antibodies for TSLP or TSLP receptor (TSLPR) upregulated miR-132 expression levels in HeLa and SiHa cells. The overexpression of miR-132 resulted in a lowered proliferation and invasiveness, decreased levels of proliferation-associated molecules marker of proliferation Ki-67 and proliferating cell nuclear antigen, and the decreased production of matrix metalloproteinase (MMP)2 and MMP9 in HeLa and SiHa cells. Compared with the control group, there was a higher level of proliferation and invasion in HeLa and SiHa cells following stimulation with rhTSLP. However, these effects induced by rhTSLP were significantly impaired in HeLa and SiHa cells with miR-132 overexpression. The results of the present study indicated that TSLP produced by CC cells downregulated miR-132 expression, and stimulated the proliferation and invasion of CC cells, thereby further promoting the development of CC. IntroductionCervical cancer (CC) is one of the most common gynecological malignancies with high rates of morbidity (0.001-0.05%) and mortality (0.0024-0.0175%), endangering the health and quality of life of women globally (1). Although the decreased incidence of CC has primarily been attributed to the widespread use of cytological screening, invasive CC remains an issue regarding the mortality rates of patients with CC. Thus, the elucidation of the molecular pathogenesis of CC is urgently required. The pathogenesis of CC remains enigmatic and may be connected with numerous factors, including infection with high-risk human papillomaviruses (HPVs) (2).Thymic stromal lymphopoietin (TSLP) is primarily produced by stromal cells, epithelial cells, fibroblasts, keratinocytes, basophils and other types of cells, including mast cells, smooth muscle cells, fibroblasts, dendritic cells, trophoblasts, and cancer or cancer-associated cells (3-5). TSLP may trigger helper T-cell 2 cytokines, and is associated with airway inflammatory disease, immunoglobulin E production, allergic respons...

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“…HA high-fat rodent diet with alcohol, H high-fat rodent diet without alcohol, A standard diet with alcohol. All groups were treated with caerulein to induce CP Concentrations of IL10 and TGFb in serum were measured to assess the effects of pReg3g on the secretion of antitumor immune cytokines [32,33]. Both lower and higher doses of pReg3g produced higher levels of serum IL10 (P \ 0.01) and TGFb (P \ 0.05) compared with those in the HAC mice (Fig.…”

Section: Preg3g Elevates Proto-oncogene Transcription While Reducingmentioning

confidence: 99%

Reg3g Promotes Pancreatic Carcinogenesis in a Murine Model of Chronic Pancreatitis

Yin

Cao

et al. 2015

Dig Dis Sci

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Role of IL-10 and TGF-β1 in local immunosuppression in HPV-associated cervical neoplasia

Cited by 119 publications

References 75 publications

From HPV Infection to Lesion Progression: The Role of HLA Alleles and Host Immunity

From HPV Infection to Lesion Progression: The Role of HLA Alleles and Host Immunity

Human thymic stromal lymphopoietin promotes the proliferation and invasion of cervical cancer cells by downregulating microRNA‑132 expression

Reg3g Promotes Pancreatic Carcinogenesis in a Murine Model of Chronic Pancreatitis

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