Role of IL-17A and neutrophilic granulocytes in the pathogenesis of psoriasis

Smolyannikova, V. A.; Карамова, А. Э.; Nefedova, M. A.

doi:10.17116/patol20208201130

Cited by 7 publications

(4 citation statements)

References 27 publications

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“…IL-17 A has been associated with neutrophilic inflammation in the setting of disorders and diseases such as psoriasis (Smolyannikova et al, 2020), asthma (Iwakura et al, 2011), and chronic obstructive pulmonary disease (Roos et al, 2015). However, IL-17A may not have a significant role in regulating neutrophilic inflammation in CRSwNP.…”

Section: Discussionmentioning

confidence: 99%

Characterizing the Neutrophilic Inflammation in Chronic Rhinosinusitis With Nasal Polyps

Ruan

Zhao

et al. 2021

Front. Cell Dev. Biol.

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The mechanisms underlying neutrophilic inflammation in chronic rhinosinusitis with nasal polyps (CRSwNP) remain poorly investigated. This study aimed to examine the factors that contribute to tissue neutrophilia in CRSwNP. The numbers of neutrophils and active caspase-3-positive apoptotic neutrophils in sinonasal tissues were assessed via immunofluorescence staining. The 95th percentile of tissue neutrophil numbers in control subjects was selected as a cut-off to define neutrophil-high (Neu-high) or neutrophil-low (Neu-low) nasal polyps (NPs). The levels of 34 inflammatory mediators in sinonasal tissues were analyzed using Bio-Plex assay. Purified human peripheral blood neutrophils were incubated with nasal tissue homogenates, and the apoptotic neutrophils were assessed via flow cytometry. The cut-off for Neu-high NPs was >10 myeloperoxidase positive cells/high-power field. Compared with Neu-low NPs, Neu-high NPs had higher tissue levels of IL-1β, IL-1Ra, IL-6, IL-8, G-CSF, MCP-1, and MIP-1α, but lower levels of IL-5, IL-13, IgE, and eosinophils. Principal component and multiple correspondence analyses revealed mixed type 1, type 2, and type 3 endotypes for Neu-low NPs, and predominant type 1 and type 3 endotypes for Neu-high NPs. Neu-high NPs had lower percentages of apoptotic neutrophils than Neu-low NPs. The numbers of neutrophils and the percentages of apoptotic neutrophils correlated with G-CSF and IL-6 levels in the NPs. Tissue homogenates from Neu-high NPs, but not those from Neu-low NPs, suppressed neutrophil apoptosis in vitro, which was reversed by anti-G-CSF treatment. Tissue neutrophil numbers were associated with difficult-to-treat disease in patients with CRSwNP after surgery. We propose that G-CSF promotes neutrophilic inflammation by inhibiting neutrophil apoptosis in CRSwNP.

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Section: Discussionmentioning

confidence: 99%

Characterizing the Neutrophilic Inflammation in Chronic Rhinosinusitis With Nasal Polyps

Ruan

Zhao

et al. 2021

Front. Cell Dev. Biol.

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“…The damage will cause skin cell death, and keratinocytes will secrete human antibacterial peptide LL-37. The DNA / LL37 complex binds to the intracellular Toll-like receptor 9 of plasmacytoid dendritic cells, causing the activation and secretion of type I interferon IFN-a and IFN-B (21). Therefore, in the model of psoriasis, it was found that bone marrowderived DC cells can be activated by LL37 / RNA complex and type I interferon, thereby promoting T cell activation and cytokine secretion (22).…”

Section: Curcumin Reduces Psoriasis-like Skin Lesions In Mice By Inhi...mentioning

confidence: 99%

Curcumin reduces inflammation in mice with the psoriasis model by inhibiting NLRP3 inflammatory bodies

Zhang¹,

2022

Cell Mol Biol (Noisy-le-grand)

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As a chronic skin disease, psoriasis is a relatively common disease among various types of skin diseases. Because this disease is often distributed throughout the patient's body and is prone to develop, it is difficult to guarantee the quality of life and physical and mental health of patients with this disease. The purpose of this article is to investigate whether curcumin can effectively inhibit the NLRP3 inflammatory body and thereby reduce the inflammation in the mouse psoriasis model. Through the use of the curcumin gel prepared and the mouse psoriasis model, the percutaneous administration was used to investigate the mechanism and mechanism of curcumin's effect on reducing inflammation in the mouse psoriasis model. In addition, in order to better explore the curative effect of curcumin on psoriasis, related experiments were conducted by setting up a control group and an experimental group. The results show that curcumin has a good inhibitory effect on NLRP3 inflammatory bodies. Curcumin can not only reduce the NLRP3 expression and inhibit the inflammation caused by IL-22 and IL-18 but also reduce the damage of psoriasis. 22 Induced phosphorylation of STAT3 almost completely inhibits phosphorylation in normal cells. Among them, curcumin inhibited IL-22-induced phosphorylation of STAT3 up to 95.6%, and inhibited IL-22 and IL-18 by about 47%.

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“…There is evidence that keratinocytes (KCs) in psoriatic lesions have antiapoptotic properties, including delaying apoptotic processes, accelerating hyperplasia and metabolism, impairing differentiation of KCs, and shortening epidermal turnover time, thus leading to manifestations such as hyperkeratosis, hypokeratosis, disappearance of granular layer, and acanthosis 2,3 . Psoriasis is also associated with long‐term infiltrations of inflammatory cells (such as T helper [Th]17 cells, Th1 cells, and neutrophils), increased levels of IL‐17 and IL‐23 in plasma and skin lesions, and vascular remodelling 4–6 . However, the pathogenesis of psoriasis has not been completely understood.…”

Section: Introductionmentioning

confidence: 99%

“…2,3 Psoriasis is also associated with long-term infiltrations of inflammatory cells (such as T helper [Th]17 cells, Th1 cells, and neutrophils), increased levels of IL-17 and IL-23 in plasma and skin lesions, and vascular remodelling. [4][5][6] However, the pathogenesis of psoriasis has not been completely understood.…”

mentioning

confidence: 99%

Protective roles of tRNA‐derived small RNA tRF‐Ile‐AAT‐019 in pathological progression of psoriasis

Zeng

Xie

Zhang

et al. 2022

Experimental Dermatology

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Psoriasis is a chronic recurrent inflammatory skin disease that affects approximately 125 million people worldwide. 1 There is evidence that keratinocytes (KCs) in psoriatic lesions have antiapoptotic properties, including delaying apoptotic processes, accelerating hyperplasia and metabolism, impairing differentiation of KCs, and shortening epidermal turnover time, thus leading to manifestations such as

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Role of IL-17A and neutrophilic granulocytes in the pathogenesis of psoriasis

Cited by 7 publications

References 27 publications

Characterizing the Neutrophilic Inflammation in Chronic Rhinosinusitis With Nasal Polyps

Characterizing the Neutrophilic Inflammation in Chronic Rhinosinusitis With Nasal Polyps

Curcumin reduces inflammation in mice with the psoriasis model by inhibiting NLRP3 inflammatory bodies

Protective roles of tRNA‐derived small RNA tRF‐Ile‐AAT‐019 in pathological progression of psoriasis

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