Role of IL-22 in Persistent Allergic Airway Diseases Caused by House Dust Mite: A Pilot Study

Abstract

Background. Persistent allergic airway diseases cause a great burden worldwide. Their pathogenesis is not clear enough. There is evidence that one of the recently described cytokine interleukin (IL) 22 may be involved in the pathogenesis of these diseases. Scientists argue if this cytokine acts as proinflammatory or anti-inflammatory agent. The aim of this study was to investigate IL-22 level in patients with persistent allergic airway diseases caused by house dust mite (HDM) in comparison with healthy individuals and to evaluate its relationship with IL-13 and IL-10 level, symptoms score and quality of life.Methods. Patients with persistent allergic rhinitis caused by HDM and having symptoms for at least 2 years with or without allergic asthma were involved into the study. Measurements of IL-22, IL-13 and IL-10 and in serum and nasal lavage was performed by ELISA. Questionnaires assessing symptoms severity and quality of life were used.Results. A tendency was observed that IL-22 in serum and nasal lavage was higher in patients with allergic airway diseases compared to control group (14.86 pg/ml vs. 7.04 pg/ml and 2.67 pg/ml vs. 1.28 pg/ml, respectively). Positive statistically significant correlation was estimated between serum IL-22 and serum IL-10 (rs=0.57, p<0.01) and IL-13 (rs=0.44, p<0.05) level. Moreover, positive significant correlation was found between IL-22 in nasal lavage and IL-10 in nasal lavage (rs=0.37, p<0.05). There was a negative statistically significant correlation between serum IL-22 and RQLQ (rs=-0.42, p<0.05).Conclusion. Our study showed a possible anti-inflammatory effect of IL-22 in patients with persistent allergic airway diseases caused by HDM.

Th22 ir Th17 vaidmuo alerginių kvėpavimo takų ligų metu

“…Bayrak Degirmenci did not find a link between IL-22 and disease severity (17). The study which investigated IL-22 level in allergic airway diseases (allergic rhinitis with or without asthma) revealed a tendency that IL-22 level in serum and nasal lavage was increased in patients with allergic airway diseases caused by house dust mite and positively correlated with IL-10 level in serum and nasal lavage (19). Moreover, IL-22 level in nasal lavage negatively correlated with eosinophil count in a nasal smear in patients with allergic rhinitis and allergic asthma.…”

“…Moreover, IL-22 level in nasal lavage negatively correlated with eosinophil count in a nasal smear in patients with allergic rhinitis and allergic asthma. A negative link was found between serum IL-22 and (Rhinoconjunctivitis Quality of Life Questionnaire) RQLQ in patients with allergic airway diseases (19). A systematic review analysing six clinical studies which investigated IL-22 level in patients with allergic airway diseases showed that IL-22 level and IL-22 gene expression in serum, plasma and nasal mucosa was higher in children and adults with allergic airway diseases than in healthy individuals (20).…”

“…A systematic review analysing six clinical studies which investigated IL-22 level in patients with allergic airway diseases showed that IL-22 level and IL-22 gene expression in serum, plasma and nasal mucosa was higher in children and adults with allergic airway diseases than in healthy individuals (20). The majority of studies revealed a significant positive correlation between IL-22 level and disease severity and symptom score (19).…”