Role of IL-24 in NK cell activation and its clinical implication in systemic lupus erythematosus

Tang, Yundi; Sun, Xiaotong; Wang, Yuxuan; Luan, Huijie; Zhang, Ruijun; Hu, Fanlei; Sun, Xiaolin; Li, Xia; Guo, Jianping

doi:10.1007/s10067-021-05618-6

Cited by 7 publications

(8 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…IL-24 serum levels are significantly higher in patients with SLE compared with healthy individuals, and elevated IL-24 levels are also associated with disease severity [ 53 ]. However, no significant difference in IL-24 serum levels was observed between SLE patients and healthy controls in two other independent studies [ 39 , 54 ]. Future studies are required to investigate the association between IL-24 and SLE.…”

Section: Il-24 In Inflammatory and Autoimmune Diseasesmentioning

confidence: 89%

“…Type 1 IFNs were also demonstrated to induce IL-24 production in murine NK cells in a STAT6-dependent manner [ 17 ]. Although IL-24 is not capable of activating peripheral NK cells [ 39 ], Yang et al demonstrated that decidual stromal cells (DSCs) produce IL-24 to promote the differentiation of CD56 bright CD16 − NK cells with regulatory phenotype that express high levels of the inhibitory receptors killer-cell immunoglobulin-like receptor (KIR)2DL1 and KIR3DL1, and inhibitory cytokines including transforming growth factor (TGF)-β, IL-8, and IL-10 [ 21 ].…”

Section: Immunobiology Of Il-24mentioning

confidence: 99%

See 1 more Smart Citation

Interleukin-24 Immunobiology and Its Roles in Inflammatory Diseases

Zhong

Zhang

Chong

2022

IJMS

View full text Add to dashboard Cite

Interleukin (IL)-24 belongs to the IL-10 family and signals through two receptor complexes, i.e., IL-20RA/IL-20RB and IL-20RB/IL22RA1. It is a multifunctional cytokine that can regulate immune response, tissue homeostasis, host defense, and oncogenesis. Elevation of IL-24 is associated with chronic inflammation and autoimmune diseases, such as psoriasis, rheumatoid arthritis (RA), and inflammatory bowel disease (IBD). Its pathogenicity has been confirmed by inducing inflammation and immune cell infiltration for tissue damage. However, recent studies also revealed their suppressive functions in regulating immune cells, including T cells, B cells, natural killer (NK) cells, and macrophages. The tolerogenic properties of IL-24 were reported in various animal models of autoimmune diseases, suggesting the complex functions of IL-24 in regulating autoimmunity. In this review, we discuss the immunoregulatory functions of IL-24 and its roles in autoimmune diseases.

show abstract

Section: Il-24 In Inflammatory and Autoimmune Diseasesmentioning

confidence: 89%

Section: Immunobiology Of Il-24mentioning

confidence: 99%

Interleukin-24 Immunobiology and Its Roles in Inflammatory Diseases

Zhong

Zhang

Chong

2022

IJMS

View full text Add to dashboard Cite

show abstract

“…Another alternative that has not been explored in detail is single or multiple genetic polymorphisms of critical proteins, receptors, or signal transduction pathways that may be relevant for NK cell modulation and tissue migration [46]. Studies with the NK cell line NK-92 suggest that several exciting analyses could be performed using migration and invasion [66][67][68][69]. For example, STAT 3 was involved in Tim-3 dysregulation of dNK, which involves immune response against pathogen and tissue rejection [27,[67][68][69].…”

Section: Nk Cells In Obesitymentioning

confidence: 99%

“…Studies with the NK cell line NK-92 suggest that several exciting analyses could be performed using migration and invasion [66][67][68][69]. For example, STAT 3 was involved in Tim-3 dysregulation of dNK, which involves immune response against pathogen and tissue rejection [27,[67][68][69]. The migration of tissue-resident NK cells from obese individuals has not been studied thoroughly in different metabolic disorders related to circulating hormone levels and could be relevant to understand the possible effect on uterine or decidual NK cells.…”

Section: Nk Cells In Obesitymentioning

confidence: 99%

A Brief Analysis of Tissue-Resident NK Cells in Pregnancy and Endometrial Diseases: The Importance of Pharmacologic Modulation

Garmendia

Sanctis

2021

Immuno

View full text Add to dashboard Cite

NK cells are lymphocytes involved in the innate and adaptative immune response. These cells are located in peripheral blood and tissues with ample functions, from immune vigilant to tolerogenic reactions. In the endometrium, NK cell populations vary depending on age, hormones, and inflammation. When pregnancy occurs, tissue-resident NK cells and conventional NK cells are recruited to protect the fetus, a tolerogenic response. On the contrary, in the inflamed endometrium, various inflammatory cells down-regulate NK tolerance and impair embryo implantation. Therefore, NK cells’ pharmacological modulation is difficult to achieve. Several strategies have been used, from progesterone, lipid emulsions to steroids; the success has not been as expected. However, new therapeutic approaches have been proposed to decrease the endometrial inflammatory burden and increase pregnancy success based on understanding NK cell physiology.

show abstract

“…Another study 165 also found that IL‐24 level was significantly elevated and correlated with disease activity in SLE patients. However, there was another report showed that no difference was found in serum IL‐24 levels between SLE patients and healthy individuals 164,166 . Therefore, the roles of IL‐19 and IL‐24 in SLE still require further investigation.…”

Section: Introductionmentioning

confidence: 96%

Roles of IL‐1 and IL‐10 family cytokines in the progression of systemic lupus erythematosus: Friends or foes?

Hsing

Chiu

et al. 2021

IUBMB Life

View full text Add to dashboard Cite

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease of unknown etiology that can affect nearly every organ system in the body. Besides genetic and environmental factors, unbalanced pro‐inflammatory and anti‐inflammatory cytokines contribute to immune dysregulation, trigger an inflammatory response, and induce tissue and organ damage. Inflammatory responses in SLE can be promoted and/or maintained by the availability of cytokines that are overproduced systemically and/or in local tissues. Several key cytokines have been considered potential targets for the reduction of chronic inflammation in SLE. Recent studies indicated that dysregulated production of several cytokines, including those of the IL‐1 family and IL‐10 family, orchestrate immune activation and self‐tolerance, play critical roles in the pathogenesis of SLE. Among IL‐1 family cytokines, IL‐1, IL‐18, IL‐33, IL‐36, IL‐37, and IL‐38 had been the most thoroughly investigated in SLE. Additionally, IL‐10 family cytokines, IL‐10, IL‐20, IL‐22, IL‐26, IL‐28, and IL‐29 are dysregulated in SLE. Therefore, a better understanding of the initiation and progression of SLE may provide suitable novel targets for therapeutic intervention. In this review, we discuss the involvement of inflammation in the pathogenesis of SLE, with a focus on IL‐1 family and IL‐10 family cytokines, and highlight pathophysiological approaches and therapeutic potential for treating SLE.

show abstract

Role of IL-24 in NK cell activation and its clinical implication in systemic lupus erythematosus

Cited by 7 publications

References 43 publications

Interleukin-24 Immunobiology and Its Roles in Inflammatory Diseases

Interleukin-24 Immunobiology and Its Roles in Inflammatory Diseases

A Brief Analysis of Tissue-Resident NK Cells in Pregnancy and Endometrial Diseases: The Importance of Pharmacologic Modulation

Roles of IL‐1 and IL‐10 family cytokines in the progression of systemic lupus erythematosus: Friends or foes?

Contact Info

Product

Resources

About