2020
DOI: 10.20517/2394-5079.2020.42
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Role of imaging in management of hepatocellular carcinoma: surveillance, diagnosis, and treatment response

Abstract: Imaging plays a notable role in hepatocellular carcinoma (HCC) surveillance, diagnosis, and treatment response assessment. Whereas HCC surveillance among at-risk patients, including those with cirrhosis, has traditionally been ultrasound-based, there are increasing data showing that this strategy is operator-dependent and has insufficient sensitivity when used alone. Several novel blood-based and imaging modalities are currently being evaluated to increase sensitivity for early HCC detection. Multi-phase compu… Show more

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Cited by 22 publications
(15 citation statements)
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References 108 publications
(149 reference statements)
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“…Serum AFP used in combination with ultrasonography slightly improves the detection rate of early HCC, but performance remains low, with a sensitivity of 63% 4 . Radiologic imaging CT or MRI plays a critical role for assessing response to HCC therapy 7 . However, these techniques are expensive and have some adverse effects.…”
Section: Introductionmentioning
confidence: 99%
“…Serum AFP used in combination with ultrasonography slightly improves the detection rate of early HCC, but performance remains low, with a sensitivity of 63% 4 . Radiologic imaging CT or MRI plays a critical role for assessing response to HCC therapy 7 . However, these techniques are expensive and have some adverse effects.…”
Section: Introductionmentioning
confidence: 99%
“…The most frequent site of HCC recurrence is extrahepatic alone (50–60%), commonly lungs and bone, followed by combined extrahepatic and intrahepatic (30–40%), and intrahepatic only (15–40%) [ 30 , 31 ]. Multiphase computed tomography (CT) scans can play a critical role in monitoring HCC recurrence [ 32 ]. Currently, the American guidelines recommend post-transplant surveillance for HCC recurrence with chest and abdominal CT scans, though optimal timing and duration is uncertain [ 25 ].…”
Section: Post-transplant Surveillance For Hcc Recurrencementioning
confidence: 99%
“…Currently, imaging techniques are essential for the diagnosis of chronic liver disease and HCC. Dynamic multiphase contrast-enhanced computed tomography (CT) scanning and magnetic resonance imaging (MRI) are the most commonly used methods to detect HCC in clinical diagnosis [112,113]. Still, there are some challenges, such as the lack of standardization in image acquisition protocols and optimization of the radiomics analysis procedure [114].…”
Section: Potential Diagnosis Of Nafld-related Hccmentioning
confidence: 99%