Role of immature platelet fraction (IPF) in sepsis patients

Tauseef, Abubakar; Zafar, Maryam; Arshad, Wafa; Thirumalareddy, Joseph; Sood, Akshat; Farooque, Umar; Nair, Sunil; Mirza, Mohsin

doi:10.4103/jfmpc.jfmpc_2293_20

Cited by 13 publications

(10 citation statements)

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“…It increases when platelet production rises and decreases when production falls. A recent systematic review showed that IPF is a reliable biomarker for sepsis diagnosis and prognosis, in terms of severity and mortality [134]. Indeed, it tends to increase before the onset of sepsis and correlates with the scores conventionally used for assessing the severity of sepsis, such as the SOFA score.…”

Section: Immature Platelet Fractionmentioning

confidence: 99%

The Value of a Complete Blood Count (CBC) for Sepsis Diagnosis and Prognosis

et al. 2021

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Sepsis represents an important global health burden due to its high mortality and morbidity. The rapid detection of sepsis is crucial in order to prevent adverse outcomes and reduce mortality. However, the diagnosis of sepsis is still challenging and many efforts have been made to identify reliable biomarkers. Unfortunately, many investigated biomarkers have several limitations that do not support their introduction in clinical practice, such as moderate diagnostic and prognostic accuracy, long turn-around time, and high-costs. Complete blood count represents instead a precious test that provides a wealth of information on individual health status. It can guide clinicians to early-identify patients at high risk of developing sepsis and to predict adverse outcomes. It has several advantages, being cheap, easy-to-perform, and available in all wards, from the emergency department to the intensive care unit. Noteworthy, it represents a first-level test and an alteration of its parameters must always be considered within the clinical context, and the eventual suspect of sepsis must be confirmed by more specific investigations. In this review, we describe the usefulness of basic and new complete blood count parameters as diagnostic and prognostic biomarkers of sepsis.

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Section: Immature Platelet Fractionmentioning

confidence: 99%

The Value of a Complete Blood Count (CBC) for Sepsis Diagnosis and Prognosis

et al. 2021

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“…On the other hand, caution is advised for this interpretation, as platelets are destroyed and IPF% is subsequently increased in patients with sepsis, regardless of the treatment with chemotherapy 16 , 24 , 25 . In this sense IPF% has been proposed as a biomarker for the prediction of sepsis diagnosis and severity 26 – 28 .…”

Section: Discussionmentioning

confidence: 99%

Immature platelet fraction predicts early marrow recovery after severe chemotherapy associated neutropenia

Salvador

Meryk

Hetzer

et al. 2023

Sci Rep

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Febrile neutropenia secondary to chemotherapy is one of the most critical complications in cancer treatment. The aim of this study was to determine if an increase in the percentage of immature platelet fraction (IPF%) might predict early neutrophil recovery following cytostatic-dependent aplasia. A retrospective cohort study compared serial complete blood counts and the level of C-reactive protein (CRP) following induction chemotherapy for Ewing sarcoma and Non-Ewing sarcoma patients. The measurements were taken on a Sysmex XE-2100 instrument. A total of 287 paired samples from 28 children after the first cycle of chemotherapy were analyzed to test if an increase in the IPF% anticipated the CRP peak and recovery of neutrophil count. The chemotherapy associated nadir of neutrophils, reticulocytes and platelets was reached at 9.7 ± 1.5, 11.0 ± 1.7 and 11.9 ± 0.9 days (mean ± SD) respectively, in Ewing sarcoma patients. Still in severe neutropenia, IPF% was the first parameter that significantly increased and anticipated the CRP peak (11.9 ± 1.6 days, mean ± SD). The IPF% continuously increased (maximum = 6.56% ± 2.8%, mean ± SD) and peaked at 12.2 ± 1.4 days (mean ± SD) after commencement of chemotherapy. Compared to neutrophil recovery (14.6 ± 1.4 days, mean ± SD), the IPF% peak was anticipated by 2.4 days (p = 0.0085). Although variably treated, in non-Ewing sarcoma patients the effect was similar and the IPF% peak anticipated neutrophil recovery by 6.8 ± 4.7 days (p < 0.01). IPF% increased significantly at > 48 h before neutrophil recovery in patients treated with chemotherapy. IPF% is an inexpensive parameter and may be valuable in the management of febrile neutropenia.

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“…However, there is contradictory literature on whether there are significant differences between patients with different sepsis severities. 82,83 The mechanisms governing changes in the age profile of platelets in pathological conditions remain unknown, however in many cases they may be associated with an enhanced clearance of platelets leading to increased haematopoiesis. Given such dysregulations in the platelet production process, it is unclear as to whether the platelets produced under these stress conditions are 'normal' and they may perhaps be more akin to those found in animal models of acute platelet depletion.…”

Section: Significance Of Altered Platelet Turnover In Diseasementioning

confidence: 99%