Role of Immune Cells in Pregnancy

Piccinni, Marie‐Pierre

doi:10.1080/0891693031000067287

Cited by 41 publications

(24 citation statements)

References 37 publications

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“…They are similar in functional nature to Th 1 and Th 2 cells, although being able to differentiate into M1 and M2 subtypes. Whereas M1 macrophages have a high capacity to produce proinflammatory cytokines (such as IL-12, IL-23 and TNF) and inflammation, M2 macrophages can alter the inflammatory response to provide the conditions for remodeling and tissue repair (Piccinni, 2003;Cupurdija et al, 2004). Although there is not enough information about the ratio of M1/M2 macrophages in the peripheral blood and decidua of women with URSA, an imbalance in favor of the M1 cells seems to provide the conditions for abortion (Hutter et al, 2013;Zhang et al, 2015).…”

Section: Discussionmentioning

confidence: 99%

Effect of Vitamin D Supplementation on Unexplained Recurrent Spontaneous Abortion: A Double-Blind Randomized Controlled Trial

Samimi¹,

Foroozanfard²,

Amini³

et al. 2016

GJHS

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Background: Recurrent spontaneous abortion is a serious problem in pregnancy, which affects between 2 and 5% of women of reproductive age. This study was designed to examine the effect of vitamin D supplementation on the occurrence of unexplained recurrent spontaneous abortion (URSA). Methods:A double-blind randomized and controlled clinical trial was performed on 80 patients with URSA. They were treated with vaginal progesterone (400 IU/day) after confirmation of pregnancy and received vitamin D and placebo in two intervention (n=40) and control groups (n=40), respectively. The incidence of abortion and the serum levels of IL-23 were examined within 20 weeks of gestation. Results:The levels of vitamin D3 prior to the start of the study were equal to 11.65±3.76 ng/ml and 11.53±2.39 ng/ml (p=0.86) in the intervention and control groups, respectively, which were decreased to 13.21±3.47 ng/ml and 11.08±2.76 ng/ml (p=0.004) at the end of the study, when the mean serum levels of IL-23 were equal to 18.4±3.78 pg/ml and 23.16±4.74 pg/ml in the two groups (p <0.004). The frequency of abortion in the control and intervention groups was equal to 5 (12.8%) and 13 (34.2%), respectively (p=0.03, OR=3.53, 95% CI= 1.12-11.2). Conclusions:Vitamin D3 leads to decreased serum levels of IL-23 and incidence of abortion among women with URSA.

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Section: Discussionmentioning

confidence: 99%

Effect of Vitamin D Supplementation on Unexplained Recurrent Spontaneous Abortion: A Double-Blind Randomized Controlled Trial

Samimi¹,

Foroozanfard²,

Amini³

et al. 2016

GJHS

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“…The clustering of stromal immune cells around the targeted glandular epithelium suggests that the uterine immune response in T. vulpecula was cell mediated, as occurs in eutherians (Robertson 2000, Piccinni 2003). The ability of serum immune titres (IgG) generated against CP4 to predict the duration of the contraceptive uterine immune response was limited.…”

Section: Uterine Secretions As Immunocontraceptive Targetsmentioning

confidence: 99%

“…However, in eutherians, semen, the conceptus (Robertson 2000), progesterone (Piccinni 2003, Lewis 2004) and in mice, early pregnancy factor (EPF; Morton 1998) induce the expression of specific cytokines able to skew the differentiation and expansion of certain lymphocyte populations, suppressing the immune response. Further immunization during oestrus results in a lower immunoglobulin response than at other times in both rats (Wira & Rossoll 1995) and mice (Gockel et al 2000).…”

Section: Major Histocompatibility Class (Mhc) IImentioning

confidence: 99%

Novel immunocontraceptive targets in mammals: uterine secretions and the conceptus; a marsupial approach

Menkhorst¹,

Cui²,

Selwood³

2008

Reproduction

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We report the first immunocontraceptive trial in mammals using a uterine-secreted protein, the marsupial shell coat protein 4 (CP4). The marsupial shell coat, which surrounds the conceptus for 60-80% of gestation, is secreted by the uterine epithelium. Following immunization against glutathione S-transferase (GST)-CP4, the fertility of female common brushtail possums (nZ6) was significantly reduced (PZ0.000), and this reduction in fertility was positively correlated with the maximum GST-CP4 humoral immune response (PZ0.025). Ultrastructural examination of the reproductive tract indicated that the cell-mediated immune response against GST-CP4 targeted the shell coat, the shell-free conceptus and the uterine glandular epithelium, thus preventing normal conceptus development and uterine secretion of shell coat proteins and nutrients. These results show that uterine-secreted proteins are promising immunocontraceptive targets, especially in pest mammal species, e.g. possum, rabbit and horse, that have uterine-secreted additions to embryonic coats, or that have late implantation requiring uterine nutrient provisioning from secretions.

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“…Immune cell functions and many networks during human pregnancy depend on the secretions of various kinds of cytokines from three different immune cells, NK cells, macrophage and T cells in the endometrium. The role of cytokines in the successful maintenance of pregnancy and in RPL has been suggested by various studies [50][51]. T helper lymphocytes can be classified into 2 cell types, Th1 and Th2, according to their differences in cytokine production.…”

Section: Cd3mentioning

confidence: 99%

Effective Treatment for Recurrent Pregnancy Loss

Makino

2010

RIB

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Abstract:Understanding the etiology of recurrent pregnancy loss (RPL) has been increasing in importance in reproductive medicine, especially in societies with low birth rates. Since the cause of human miscarriage is often complicated and multifactorial, effective treatment for the successful maintenance of pregnancy requires the comprehensive clinical management of recurrent wastages. Immunology for the maintenance of pregnancy is a very attractive field; however, the role of immunology during human gestation cannot be confirmed in couples with a history of recurrent pregnancy loss unless other clinical causes of miscarriage are especially ruled out. Balanced chromosomal rearrangements have been found at an increased frequency in couples with recurrent pregnancy loss compared with the general population. The major anomalies are Robertosonian or reciprocal translocations, while most minor variants include pericentric inversion of chromosome 9. Both major and minor anomalies result in a spontaneous abortion rate of approximately 80-90%. Though the incidences of these chromosomal abnormalities vary in reported studies, a survey indicated an incidence of 9.8% (3.9% in male partners and 5.9% in female partners) among 1,639 couples with a history of recurrent pregnancy loss. Congenital uterine anomaly resulting in a suboptimal uterine environment may influence ovum implantation and early fetal development and may be a candidate in the etiology of reproductive wastage. A review on the relation between congenital uterine anomalies and the spontaneous abortion rate concluded that a precise diagnosis of uterine cavity deformity, especially arcuate uterus, is a key issue for determining the clinical prognosis during human gestation. After establishing diagnostic criteria for uterine cavity anomaly, 278 congenital uterine anomalies were detected in a series of 2,061 hysterosalpingographies (13.5%) performed in women with a history of recurrent pregnancy loss. Among these abnormalities, the incidences of spontaneous abortion were equally high among patients with arcuate uterus and those with partial septate uterus. A few studies on abortion mechanism in patients with congenital uterine anomalies have been reported. Histological findings using CD34-positive staining indicate the lack of a blood capillary system in both the uterine septum and the fundus muscle layer. The results of metroplastic surgery on congenital uterine anomaly are also controversial. Based on our fundamental findings of the maldistribution of uterine capillaries, we performed ideal metroplastic surgery in 173 women and significantly

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Role of Immune Cells in Pregnancy

Cited by 41 publications

References 37 publications

Effect of Vitamin D Supplementation on Unexplained Recurrent Spontaneous Abortion: A Double-Blind Randomized Controlled Trial

Effect of Vitamin D Supplementation on Unexplained Recurrent Spontaneous Abortion: A Double-Blind Randomized Controlled Trial

Novel immunocontraceptive targets in mammals: uterine secretions and the conceptus; a marsupial approach

Effective Treatment for Recurrent Pregnancy Loss

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