Role of immune factors in bioavailability and toxicity of carbon nanomaterials

Khan, Haseeb A.; Khan, Isra; Lee, Yong-Kyu

doi:10.1016/b978-0-12-813691-1.00015-4

Cited by 4 publications

(4 citation statements)

References 83 publications

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“…The results suggest that a leading contribution to the hair growth-promoting effect of AGN extract and decursin was the modulation of both pro-and anti-inflammatory cytokines. The Western blot and immunohistochemical analyses of TNF-α, IL-1β, IL-4, and IL-13 in the dorsal skin showed that AGN extract and decursin significantly reduced pro-inflammatory cytokines (TNF-α and IL-1β), which trigger progressive inflammatory responses [6,8]. Conversely, they increased anti-inflammatory cytokine (IL-4 and IL-13) levels which can inhibit the synthesis of pro-inflammatory cytokines and act as antagonists of pro-inflammatory cytokine receptors [6,7].…”

Section: Discussionmentioning

confidence: 99%

“…Inflammatory responses are fundamentally triggered by activated immune cells according to the invasion of antigens [5]. To contrast, fine regulations in inflammatory responses are accomplished through the antagonism between pro-inflammatory cytokines, such as tumor necrosis factor α (TNF-α) and interleukin (IL)-1β, and anti-inflammatory cytokines, such as IL-4 and IL-13 [6][7][8]. Some studies have demonstrated the relationship between inflammatory responses and hair loss [9,10].…”

Section: Introductionmentioning

confidence: 99%

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Effects of Decursin and Angelica gigas Nakai Root Extract on Hair Growth in Mouse Dorsal Skin via Regulating Inflammatory Cytokines

Lee

Kim

et al. 2020

Molecules

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This current study investigates the facilitative effects and mechanisms of decursin, a major component of Angelica gigas Nakai (AGN), and AGN root extract on hair growth in mice. We perform high-performance liquid chromatography on AGN extract to show it contains 7.3% decursin. Hairs in mouse dorsal skin are shaved distilled in water, 0.15% decursin, and 2% AGN root extract (0.15% decursin in the diluted extract) and topically applied twice a day for 17 days. Hematoxylin and eosin staining are done to examine the morphological changes in the hair follicles. To compare the effects of decursin and AGN extract on inflammatory cytokines in the dorsal skin, Western blot analysis and immunohistochemistry for tumor necrosis factor α (TNF-α) and interleukin (IL)-1β as pro-inflammatory cytokines, and IL-4 and IL-13 as anti-inflammatory cytokines are conducted. The results show that the application of decursin and AGN extract confer effects on hair growth. Hair growth is significantly facilitated from seven days after the treatments compared to that in the control group, and completely grown hair was found 17 days after the treatments. The protein levels and immunoreactivity of TNF-α and IL-1β in this case are significantly decreased, whereas the IL-4 and IL-13 levels and immunoreactivity are significantly increased compared to those in the control group. Additionally, high-mobility group box 1, an inflammatory mediator, is elevated by the topical application of decursin and AGN extract. Taken together, the treatment of mouse dorsal skin with AGE root extract containing decursin promotes hair growth by regulating pro- and/or anti-inflammatory cytokines. We, therefore, suggest that AGN root extract as well as decursin can be utilized as materials for developing hair growth-facilitating treatments.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effects of Decursin and Angelica gigas Nakai Root Extract on Hair Growth in Mouse Dorsal Skin via Regulating Inflammatory Cytokines

Lee

Kim

et al. 2020

Molecules

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“…Thus, one of the biggest concerns related to the use of CNTs as vaccine structures or other therapeutic-prophylactic proposals is the risk of bioaccumulation and toxicity. 24 , 161 …”

Section: Challenges In Using Carbon Nanotubes As Vaccine Agentsmentioning

confidence: 99%

“…Thus, one of the biggest concerns related to the use of CNTs as vaccine structures or other therapeutic-prophylactic proposals is the risk of bioaccumulation and toxicity. 24,161 However, their small size makes it possible for them to spread throughout the body and reach crucial sites, an ability that may be either beneficial or harmful in vaccineimmunotherapeutic processes, depending on the design of the nanostructure. To prevent or reduce toxicity, CNTs must be functionalized to make them more soluble in water, more biocompatible, and, consequently, less toxic.…”

Section: Aspects Of Toxicity and Functionalizationmentioning

confidence: 99%

Advances and Perspectives in the Use of Carbon Nanotubes in Vaccine Development

Lima¹,

Diaz²,

Justo³

et al. 2021

IJN

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Advances in nanobiotechnology have allowed the utilization of nanotechnology through nanovaccines. Nanovaccines are powerful tools for enhancing the immunogenicity of a specific antigen and exhibit advantages over other adjuvant approaches, with features such as expanded stability, prolonged release, decreased immunotoxicity, and immunogenic selectivity. We introduce recent advances in carbon nanotubes (CNTs) to induce either a carrier effect as a nanoplatform or an immunostimulatory effect. Several studies of CNT-based nanovaccines revealed that due to the ability of CNTs to carry immunogenic molecules, they can act as nonclassical vaccines, a quality not possessed by vaccines with traditional formulations. Therefore, adapting and modifying the physicochemical properties of CNTs for use in vaccines may additionally enhance their efficacy in inducing a T cell-based immune response. Accordingly, the purpose of this study is to renew and awaken interest in and knowledge of the safe use of CNTs as adjuvants and carriers in vaccines.

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Four decades of chemotherapy-induced cognitive dysfunction: comprehensive review of clinical, animal and in vitro studies, and insights of key initiating events

Dias-Carvalho

Ferreira

et al. 2021

Arch Toxicol

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Role of immune factors in bioavailability and toxicity of carbon nanomaterials

Cited by 4 publications

References 83 publications

Effects of Decursin and Angelica gigas Nakai Root Extract on Hair Growth in Mouse Dorsal Skin via Regulating Inflammatory Cytokines

Effects of Decursin and Angelica gigas Nakai Root Extract on Hair Growth in Mouse Dorsal Skin via Regulating Inflammatory Cytokines

Advances and Perspectives in the Use of Carbon Nanotubes in Vaccine Development

Four decades of chemotherapy-induced cognitive dysfunction: comprehensive review of clinical, animal and in vitro studies, and insights of key initiating events

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