Role of immunoregulatory transcription factors in differential immunomodulatory effects of tocotrienols

Wilankar, Chandan; Sharma, Deepak; Checker, Rahul; Khan, Nazir M.; Patwardhan, Raghavendra S.; Patil, Anand; Sandur, Santosh K.; Devasagayam, T.P.A.

doi:10.1016/j.freeradbiomed.2011.03.038

Cited by 33 publications

(27 citation statements)

References 61 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…While tocopherols have been widely studied for their antioxidant properties, there are few studies of tocotrienols on this sense. Recent studies have shown that tocotrienols possess a strong anti-carcinogenic and neuroprotective effect as well also involved in reducing cholesterol levels as compared to tocopherols (Sen et al 2007;Aggarwal et al 2010;Miyazawa et al 2011;Wilankar et al 2011). It has been proposed that these beneficial effects might be due to the unsaturation of their aliphatic tail which makes easier their penetration to tissues and confers them a higher antioxidant power (Samarjit et al 2007).…”

Section: Tocotrienols and Tocopherolsmentioning

confidence: 99%

Achiote (Bixa orellana L.): a natural source of pigment and vitamin E

et al. 2017

View full text Add to dashboard Cite

Commercialization of agricultural products, including seeds and its derived products, represents an important economic source for developing countries. Natural colorants obtained from the seeds of achiote plant (annatto) have been used since pre-Hispanic times. Also, production of this crop has been important for Mayan cuisine. Annual world production of achiote seeds is approximately 14,500 tons (dry weight). Two thirds of the production is commercialized as dried seeds and the rest as colorant. Latin America produces 60% of the total world production, followed by Africa (27%) and Asia (12%). The main producers in Latin America are Peru, Brazil and Mexico. The purpose of the present paper is to review the most recent literature on Bixa orellana L. focusing on bixin, norbixin, tocotrienols and tocopherols biosynthesis, use and industrial applications of annatto extracts, as well as its nutraceutical potential and its benefits for human health.

show abstract

Section: Tocotrienols and Tocopherolsmentioning

confidence: 99%

Achiote (Bixa orellana L.): a natural source of pigment and vitamin E

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Moreover, vitamin E (dl-α-tocopheryl acetate) has been observed to improve mitogen-stimulated lymphocyte proliferation in healthy elderly subjects (Meydani et al, 1990). Reportedly, palm oil tocotrienol-rich fraction (TRF) was also able to improve quantitative measures of chronic pancreatic damage in a rat model (González et al, 2011), and α-tocotrienol (GT) was more effective in suppressing Con A-induced T cell proliferation than AT (Wilankar et al, 2011). Our study elucidated both the mixture tocotrienols alone in higher dosage and combining with α-tochopherol even at lower dose had the capability to enhance lymphocyte proliferation.…”

Section: Discussionmentioning

confidence: 99%

Effect of Palm Tocotrienols versus Alpha-Tocopherol on Lymphocyte's Proliferation in Streptozotocin-Induced Diabetic Rats

Mojani¹,

Sarmadi²,

Rahmat³

et al. 2013

IMMU

View full text Add to dashboard Cite

In this study, the effect of palm oil based vitamin E was evaluated on lymphocyte`s proliferation in streptozotocin-induced diabetic rats. Diabetic rats were supplemented with alphatocopherol (AT) and/or mixed-tocotrienols (TT) at two dosages 6 and 12mg/kg for 8 weeks. Treated rats were sacrificed and their spleens isolated for lymphocyte proliferation assay in response to two mitogens namely lipopolysaccharide (LPS) and phytohemagglutinin (PHA). Our results indicated that in the resting state, the lymphocytes of untreated diabetic rats had a marked increase in cell proliferation compared with the treated rats; however, upon stimulation with PHA or LPS, the untreated diabetic lymphocytes failed to respond. Lymphocytes from animals treated with AT (12 mg/kg) alone and the combination of two supplements (AT and TT for 6 mg/kg) showed a significant proliferation when challenged with mitogens where the particular supplementations ameliorate lymphocyte impairment by reconstituting the cellular proliferation in diabetic rats. This study suggested that the supplementation of AT alone at higher concentration or combination with TT even at lower doses can restore the lymphocyte proliferation which is an important phase in immune cell responses.

show abstract

“…MMP was assessed using the mitochondrial-specific cationic fluorescent probe JC-1 (10 µM) by spectroflourimetric method as described previously (20).…”

Section: Measurement Of Change In Mitochondrial Membrane Potential (Mmp)mentioning

confidence: 99%

“…Cytosolic extracts were prepared as described earlier (20). Vehicle treated cells served as a control.…”

Section: Western Blot Analysismentioning

confidence: 99%

See 1 more Smart Citation

1,4-Naphthoquinone, a pro-oxidant, ameliorated radiation induced gastro-intestinal injury through perturbation of cellular redox and activation of Nrf2 pathway

Gambhir¹

2016

DD&T

View full text Add to dashboard Cite

Role of immunoregulatory transcription factors in differential immunomodulatory effects of tocotrienols

Cited by 33 publications

References 61 publications

Achiote (Bixa orellana L.): a natural source of pigment and vitamin E

Achiote (Bixa orellana L.): a natural source of pigment and vitamin E

Effect of Palm Tocotrienols versus Alpha-Tocopherol on Lymphocyte's Proliferation in Streptozotocin-Induced Diabetic Rats

1,4-Naphthoquinone, a pro-oxidant, ameliorated radiation induced gastro-intestinal injury through perturbation of cellular redox and activation of Nrf2 pathway

Contact Info

Product

Resources

About