Role of Immunosuppressive Regimen on the Incidence and Characteristics of Cytomegalovirus Infection in Heart Transplantation: A Single-Center Experience With Preemptive Therapy

Santo, Luca Salvatore De; Romano, Gianpaolo; Mastroianni, Ciro; Roberta, C.; Corte, Alessandro Della; Amarelli, Cristiano; Maiello, Ciro; Giannolo, B; Marra, Claudio; Ragone, Enrico; Grimaldi, Maria; Utili, Riccardo; Scardone, Michelangelo; Cotrufo, Maurizio

doi:10.1016/j.transproceed.2005.06.080

Cited by 16 publications

(4 citation statements)

References 9 publications

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“…First, the disclosed incidence is lower by far than that currently reported (38-173%) [16]. This could be partly explained by the publication biases mentioned before and partly by the effectiveness of our current practice of active infection surveillance and prophylaxis that has been previously described [17]. Second, hospital mortality rate in the transplanted infected cohort, which also proved lower than those usually reported, was lower than that observed in the rest of the infected subgroup of present study.…”

Section: Discussioncontrasting

confidence: 56%

Microbiologically documented nosocomial infections after cardiac surgery: an 18-month prospective tertiary care centre report☆☆☆★

Santo

Bancone

Santarpino

et al. 2008

European Journal of Cardio-Thoracic Surgery

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Section: Discussioncontrasting

confidence: 56%

Microbiologically documented nosocomial infections after cardiac surgery: an 18-month prospective tertiary care centre report☆☆☆★

Santo

Bancone

Santarpino

et al. 2008

European Journal of Cardio-Thoracic Surgery

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“…The risk of CMV infection and disease is influenced by post‐transplant immunosuppression (Table 1) (14–19). However, studies that determine the true impact of immunosuppression on CMV viremia and disease are lacking.…”

Section: Current Strategies To Prevent CMV Infectionmentioning

confidence: 85%

Cytomegalovirus infection and disease in the new era of immunosuppression following solid organ transplantation

Fisher

2009

Transplant Infectious Dis

110

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As the most prevalent pathogen among transplant patients, cytomegalovirus (CMV) affects up to three-quarters of all solid organ transplant recipients. While we have made great strides in preventing CMV infection and disease in the early post-transplant period, late CMV infection and indirect effects due to viral immunomodulation remain problematic. Changing immunosuppression practices, including the increasing use of T-cell depleting induction antibodies, have the potential to affect the risk for CMV infection and disease, even in the face of good prophylactic and preemptive therapy. The purpose of this review article is to discuss the impact of CMV infection on long-term allograft outcomes and to re-evaluate the risks and management strategies for prevention of CMV in the framework of evolving modern immunosuppressive strategies.

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“…This result is inconsistent with previous reports describing HRV C and more severe cases associated with HRV C among hospitalized children and adults [Piralla et al, 2009; Lau et al, 2009], such as asthma exacerbation [Miller et al, 2009] or pneumonia [Lau et al, 2009]. One limitation in our investigation was the non‐inclusion of hospitalized patients with severe respiratory diseases, although ILI was poorly observed among renal transplant outpatients in the study, probably due to immune disturbances, steroids, and use of other immunosuppressive drugs [Hendley, 1998; De Santo et al, 2005; Oshansky et al, 2009].…”

Section: Discussionmentioning

confidence: 99%

Rhinovirus species and their clinical presentation among different risk groups of non‐hospitalized patients

Watanabe

Carraro

Kamikawa

et al. 2010

Journal of Medical Virology

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Infections caused by Human Rhinoviruses (HRVs) account for 25-50% of respiratory illnesses among individuals presenting influenza-like illness (ILI). HRVs could be classified in at least three species: HRV-A, HRV-B, and HRV-C. The HRV-C species has frequently been described among children and has led to severe illness resulting in hospitalization; however, the occurrence among adults is unknown. The aim of this study was to assess the clinical presentation and species distribution of HRV infections in different populations during 2001-2008. A total of 770 samples were collected. Subjects consisted of 136 adults from the general community and 207 health-care workers (2001-2003), 232 renal-transplanted outpatients (2002-2004), 70 children with congenital heart disease (2005) and 125 children from a day-care center (2008). Amplification of HRV genes was performed by reverse transcriptase-polymerase chain reaction (RT-PCR) and followed by sequencing and phylogenetic analysis. HRV was detected in 27.4% of samples (211/770), with 72 children (36.9%) and 139 adults infected (24.2%). A total of 89.61% (138/154) unknown HRV strains were sequenced, and 79.22% (122/138) were analyzed. We identified 74 isolates (60.7%) of the HRV A species, 21 (17.2%) of the HRV B species and 27 isolates (22.1%) of the HRV C species. HRV species A and B caused ILI among adult patients, whereas HRV-C did not. The dynamics of infection among different species deserve further analysis.

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Role of Immunosuppressive Regimen on the Incidence and Characteristics of Cytomegalovirus Infection in Heart Transplantation: A Single-Center Experience With Preemptive Therapy

Cited by 16 publications

References 9 publications

Microbiologically documented nosocomial infections after cardiac surgery: an 18-month prospective tertiary care centre report☆☆☆★

Microbiologically documented nosocomial infections after cardiac surgery: an 18-month prospective tertiary care centre report☆☆☆★

Cytomegalovirus infection and disease in the new era of immunosuppression following solid organ transplantation

Rhinovirus species and their clinical presentation among different risk groups of non‐hospitalized patients

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