High-quality development (HQD) is a positive initiative in China to promote sustainable development. Promoting HQD in the Yellow River Basin (YRB) is a major national strategy for China. The YRB is an important ecological barrier and economic zone in China, which comprises nine provinces, including Qinghai, Sichuan, Gansu, Ningxia, Inner Mongolia, Shaanxi, Shanxi, Henan and Shandong. The objective of this paper is to provide a comprehensive evaluation of the HQD of the nine provinces in the YRB. It clarifies the basic connotation of HQD and constructs a comprehensive evaluation index system for HQD according to the principles of comprehensiveness, distinctiveness, openness, refinement and feasibility. The comprehensive evaluation index system includes four dimensions: economic development, technology innovation, society and livelihood, and ecological security, which contain 28 secondary indicators. The combined method of coupling development and entropy weight termed the “technique for order preference by similarity to an ideal solution (TOPSIS)” was selected to make a comprehensive evaluation of the HQD of the nine provinces in the YRB from the time dimension and the space dimension, respectively. It was found that there are still problems, such as the differentiation of HQD, the low comprehensive development degree (CDD), and the low development coupling degree (DCD) in some provinces.