Role of Inflammation in Atherosclerosis

Spagnoli, Luigi Giusto; Bonanno, Elena; Sangiorgi, Giuseppe; Mauriello, Alessandro

doi:10.2967/jnumed.107.038661

Cited by 245 publications

(161 citation statements)

References 147 publications

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“…There is a relationship between atherosclerosis and inflammation which plays an important role in all stages of atherosclerosis. Many studies have shown that similar inflammatory markers, such as tumor necrosis factor (TNF) and interleukin 6 (IL-6), increase in COPD and atherosclerosis [4][5][6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Serum fetuin-A levels are associated with carotid intima–media thickness in patients with normotensive chronic obstructive pulmonary disease

et al. 2014

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Background: There are contradictory reports about the relationship between fetuin-A and atherosclerotic process. Coronary artery disease is the most important cause of mortality in patients with chronic obstructive pulmonary disease (COPD). We aimed to investigate the association of serum fetuin-A level with mean carotid intima-media thickness (cIMT) and ankle-brachial index (ABI) in COPD. Methods: We evaluated the association of serum fetuin-A level, mean cIMT and ABI in normotensive subjects with COPD (n = 65) and with non-COPD (n = 50 (0.69 [0.50-0.98] vs. 0.62 [0.44-0.98] mm, p = 0.034, respectively) in the COPD group. There was a significant negative correlation between mean cIMT and fetuin-A levels (r = -0.320, p = 0.032). Age (b ± SE: 0.002 ± 0.001, p = 0.035) (Cardiol J 2014; 21, 2: 191-197)

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Section: Introductionmentioning

confidence: 99%

Serum fetuin-A levels are associated with carotid intima–media thickness in patients with normotensive chronic obstructive pulmonary disease

et al. 2014

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“…1) Although the degree of stenosis remains the major risk factor for cardiovascular and cerebrovascular events, plaque morphology has recently emerged as an important contributory factor. [2][3][4][5][6][7][8] In fact, the presence of atherosclerotic unstable plaques is associated with a markedly increased risk of clinical complications. 9) Indeed, although the degree of carotid atherosclerotic stenosis is recognized as an important risk factor for stroke, it is well known that whereas many critical stenoses remain stable and never cause cerebrovascular events, others quickly lead to the onset of a serious, potentially fatal condition.…”

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confidence: 99%

Can Carotid Plaque Histology Selectively Predict the Risk of an Acute Coronary Syndrome?

et al. 2011

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SummaryThe aim of this study was to assess whether carotid plaque morphology is an independent predictive factor of stroke and, innovatively, of acute coronary syndrome (ACS). We analyzed morphological aspects of carotid atherosclerotic plaque associated with an increased risk of ACS and stroke. We examined 72 carotid endarterectomy (CEA) specimens obtained between January 2005 and February 2009. All patients underwent follow-up for 12 months after the revascularization treatment to assess the occurrence of ACS and stroke. Data obtained showed that in patients with a previous ACS and in those who had developed an ACS during follow-up after CEA, the degree of carotid plaque calcification was more severe than in patients who did not develop an ACS, either before CEA or during follow-up. However, plaques of patients with ACS were mostly devoid of a significant inflammatory component, whereas a rich infiltrate, mainly consisting of monocytes-macrophages and lymphocytes, was present in plaques of subjects who did not develop an ACS. This element was particularly important since strokes occurred only in the latter group of patients (62% versus 0%). Therefore, we deduced that inflammation, from the histological point of view, is more correlated with cerebral circulation disorders than with coronary disease. In conclusion, while the finding of a soft plaque with a large necrotic core and a marked inflammatory component, often characterized by acute complications, may be predictive of an increased risk of cerebrovascular events, a heavily calcified plaque may be indicative of a high risk of coronary events. (Int Heart J 2011; 52: 72-77)

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“…It is widely accepted that inflammation plays a key role in the pathogenesis of atherosclerosis (11). Chronic inflammatory process can develop into an acute clinical event by induction of plaque rupture and thrombosis.…”

Section: Discussionmentioning

confidence: 99%

C-Reactive Protein in Estimating Inflammatory Status in Patients with Acute Coronary Syndrome

Dimitrijevic¹,

Đorić-Stojčevski²,

Ignjatović³

et al. 2008

Journal of Medical Biochemistry

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C-Reactive Protein in Estimating Inflammatory Status in Patients with Acute Coronary Syndrome Chronic inflammation plays a key role in the pathogenesis of atherosclerosis, and is considered as a risk factor for the occurrence of acute coronary events, together with traditional risk factors such as age, smoking, hypercholesterolemia, diabetes mellitus and genetic predisposition. In this study, inflammatory status was estimated in patients with acute coronary syndrome. C-reactive protein, erythrocyte sedimentation rate and white blood cell count were measured at admission to the hospital in 25 patients with unstable angina pectoris and 31 patients with acute myocardial infarction, and compared with healthy control group (n = 59). C-reactive protein was the only parameter that differed significantly between all three groups (p < 0.0001), and patients with unstable angina had higher levels (median 7.28 mg/L) than patients with myocardial infarction (4.10 mg/L) and control group (1.07 mg/L). The obtained results show that levels of chronic inflammation in patients with acute coronary syndrome are significantly higher than baseline inflammation levels in a healthy population.

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Role of Inflammation in Atherosclerosis

Cited by 245 publications

References 147 publications

Serum fetuin-A levels are associated with carotid intima–media thickness in patients with normotensive chronic obstructive pulmonary disease

Serum fetuin-A levels are associated with carotid intima–media thickness in patients with normotensive chronic obstructive pulmonary disease

Can Carotid Plaque Histology Selectively Predict the Risk of an Acute Coronary Syndrome?

C-Reactive Protein in Estimating Inflammatory Status in Patients with Acute Coronary Syndrome

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