Role of inflammatory biomarkers in diabetic peripheral neuropathy

Jin, Heung Yong; Park, Tae Sun

doi:10.1111/jdi.12794

Cited by 78 publications

(61 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Human studies showed correlation between circulating cholesterol and lipids in development and progression of neuropathy [11][12][13] albeit the mechanisms remain unexplained. LXRα and β are ligand-activated nuclear receptors that bind metabolites of cholesterol 18,19 .…”

Section: Discussionmentioning

confidence: 99%

Neuronal LXR Regulates Neuregulin 1 Expression and Sciatic Nerve-Associated Cell Signaling in Western Diet-fed Rodents

Gavini

Bonomo

Mansuy‐Aubert

2020

Sci Rep

View full text Add to dashboard Cite

Neuropathic pain caused by peripheral nerve injuries significantly affects sensory perception and quality of life. Accumulating evidence strongly link cholesterol with development and progression of Obesity and Diabetes associated-neuropathies. However, the exact mechanisms of how cholesterol/ lipid metabolism in peripheral nervous system (PNS) contributes to the pathogenesis of neuropathy remains poorly understood. Dysregulation of LXR pathways have been identified in many neuropathic models. The cholesterol sensor, LXR α/β, expressed in sensory neurons are necessary for proper peripheral nerve function. Deletion of LXR α/β from sensory neurons lead to pain-like behaviors. In this study, we identified that LXR α/β expressed in sensory neurons regulates neuronal Neuregulin 1 (Nrg1), protein involved in cell-cell communication. Using in vivo cell-specific approaches, we observed that loss of LXR from sensory neurons altered genes in non-neuronal cells located in the sciatic nerve (potentially representing Schwann cells (SC)). Our data suggest that neuronal LXRs may regulate non-neuronal cell function via a Nrg1-dependent mechanism. The decrease in Nrg1 expression in DRG neurons of WD-fed mice may suggest an altered Nrg1-dependent neuron-SC communication in Obesity. The communication between neurons and non-neuronal cells such as SC could be a new biological pathway to study and understand the molecular and cellular mechanism underlying Obesity-associated neuropathy and PNS dysfunction. Peripheral neuropathy arising from metabolic disorders such as Obesity and pre-diabetes leads to loss of sensory perception, pain, and reduced quality of life 1-3. Currently, there are no disease modifying drugs available, as the neurobiology underlying this type ofneuropathic pain is still unclear. Many previous studies have focused on glucose as a major culprit in the development of diabetes-associated neuropathies 4-6 , but recent body of evidence indicated that altered lipid signaling in the peripheral nervous system (PNS) 7-10 is involved. Evidence in obese and diabetic patients, in addition to murine model of type II diabetes and pre-diabetes strongly suggest that circulating cholesterol and cholesterol pathways are linked to development and progression of neuropathy 11-13. Notably, sensory neurons located in the dorsal root ganglia (DRG) and associated Schwann cells (SC), satellite cells or immune cells in the nerves are not protected from the blood-brain or blood-nerve barrier 14 suggesting that, in contrast to the central nervous system (CNS), they could sense and/or be affected by circulating lipids. Previously, we found that peripheral neurons express cholesterol sensor and transcription factor: liver X receptors (LXR α/β) (NR1H3 and NR1H2) 15-17. LXR α/β are ligand-activated nuclear receptors that bind metabolites of cholesterol 18,19. Many previous findings strongly suggested that, LXRs play an important role in nervous systems 16,17 but, while the function of LXR α/β in regulating cholesterol efflux (in liver, intestin...

show abstract

Section: Discussionmentioning

confidence: 99%

Neuronal LXR Regulates Neuregulin 1 Expression and Sciatic Nerve-Associated Cell Signaling in Western Diet-fed Rodents

Gavini

Bonomo

Mansuy‐Aubert

2020

Sci Rep

View full text Add to dashboard Cite

show abstract

“…Human studies showed correlation between circulating cholesterol and lipids in development and progression of neuropathy 11-13 albeit the mechanisms remain unexplained. LXRα and β are ligand-activated nuclear receptors that bind metabolites of cholesterol 18,19 .…”

Section: Discussionmentioning

confidence: 99%

“…Many previous studies have focused on glucose as a major culprit in the development of Obesity-associated neuropathies 4-6 , but recent body of evidence indicated that altered plasma lipid signaling in the peripheral nervous system (PNS) 7-10 is involved. Indeed, evidence on obese and diabetic patients, and murine model of Type II diabetes strongly suggest that circulating cholesterol and inflammation are linked to development and progression of neuropathy 11-13 . However, the mechanisms underlying how lipids affect cells of the PNS are still unclear.…”

Section: Introductionmentioning

confidence: 99%

Neuronal LXR Regulates Neuregulin-1 Expression and Sciatic Nerve-Associated Cell signaling

Gavini

Bonomo

Mansuy‐Aubert

2020

Preprint

View full text Add to dashboard Cite

show abstract

“…DPN is thought to be caused by the cellular damage and inflammatory cascade induced by chronic hyperglycaemia and dyslipidaemia, which arise from insulin resistance. However, many people with established T2DM develop DPN despite adequate glucose control, and current evidence does not prove the effectiveness of intensive glycaemic control on DPN progression in T2DM .…”

Section: Discussionmentioning

confidence: 99%

“…35 The individually tailored exercise counselling approach might also enhance self-management skills and facilitate building exercise habits into lifestyle, as DPN is associated with a lower level of self-care in areas including exercise and diet management. 36 DPN is thought to be caused by the cellular damage and inflammatory cascade induced by chronic hyperglycaemia and dyslipidaemia, [37][38][39][40][41] which arise from insulin resistance. However, many people with established T2DM develop DPN despite adequate glucose control, 3 and current evidence does not prove the effectiveness of intensive glycaemic control on DPN progression in T2DM.…”

Section: Adverse Eventsmentioning

confidence: 99%

Aerobic exercise training may improve nerve function in type 2 diabetes and pre‐diabetes: A systematic review

Dennis

Kiernan

et al. 2018

Diabetes Metabolism Res

View full text Add to dashboard Cite

Summary Diabetic neuropathy is a major complication of type 2 diabetes. Emerging evidence also suggests that people with pre‐diabetes may develop similar symptoms related to nerve dysfunction. While regular exercise provides many benefits to patients with diabetes, whether exercise influences nerve function has not been established. As such, the aim of this systematic review was to evaluate current evidence regarding the effect of exercise training on the progression and development of diabetic neuropathy. A systematic search of MEDLINE (Ovid), CINAHL, AMED, PEDro, the Cochrane Library, Embase, and Scopus databases identified a total of 12 studies that were eligible for inclusion in this systematic review. Quality rating and data extraction were performed by two independent reviewers. The 12 included studies examined people with pre‐diabetes (n = 1) and with type 2 diabetes (n = 11). There was heterogeneity of study quality and exercise type and dosage among these studies. Eleven studies reported that exercise training had a positive influence on nerve function or neuropathy‐related symptoms; and only one study reported mild adverse events. Evidence from this systematic review suggests aerobic exercise training may positively influence nerve function among people with type 2 diabetes, with minimal risk of adverse events. Further research will be required to determine the optimal dosage of exercise training and the effect on nerve function in pre‐diabetes and in women with previous gestational diabetes. This review is registered on PROSPERO (CRD42018088182).

show abstract

Role of inflammatory biomarkers in diabetic peripheral neuropathy

Abstract: Inflammatory pathway from hyperglycemia to diabetic peripheral neuropathy is very important in diagnosis and management. Inflammatory cytokine can be used for prediction and progression of diabetic peripheral neuropathy.

Cited by 78 publications

References 7 publications

Neuronal LXR Regulates Neuregulin 1 Expression and Sciatic Nerve-Associated Cell Signaling in Western Diet-fed Rodents

Neuronal LXR Regulates Neuregulin 1 Expression and Sciatic Nerve-Associated Cell Signaling in Western Diet-fed Rodents

Neuronal LXR Regulates Neuregulin-1 Expression and Sciatic Nerve-Associated Cell signaling

Aerobic exercise training may improve nerve function in type 2 diabetes and pre‐diabetes: A systematic review

Contact Info

Product

Resources

About