Role of Innate lymphoid Cells in Obesity and Insulin Resistance

Chen, Hong; Sun, Lichao; Feng, Li; Yin, Yue; Zhang, Weizhen

doi:10.3389/fendo.2022.855197

Cited by 7 publications

(5 citation statements)

References 197 publications

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“…Moreover, recent studies also found that ILC1s in the adipose tissue participate in developing inflammation and insulin resistance. HFD-induced obesity increases the number of ILC1s and induces them to produce IFN-γ and TNFα in the visceral adipose tissue (VAT), then ILC1s-derived IFN-γ and TNFα accelerate M1 macrophages accumulation and promote insulin resistance [211].…”

Section: Other Immune Cells and Insulin Resistancementioning

confidence: 99%

Macrophages, Chronic Inflammation, and Insulin Resistance

Yang

et al. 2022

Cells

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The prevalence of obesity has reached alarming levels, which is considered a major risk factor for several metabolic diseases, including type 2 diabetes (T2D), non-alcoholic fatty liver, atherosclerosis, and ischemic cardiovascular disease. Obesity-induced chronic, low-grade inflammation may lead to insulin resistance, and it is well-recognized that macrophages play a major role in such inflammation. In the current review, the molecular mechanisms underlying macrophages, low-grade tissue inflammation, insulin resistance, and T2D are described. Also, the role of macrophages in obesity-induced insulin resistance is presented, and therapeutic drugs and recent advances targeting macrophages for the treatment of T2D are introduced.

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Section: Other Immune Cells and Insulin Resistancementioning

confidence: 99%

Macrophages, Chronic Inflammation, and Insulin Resistance

Yang

et al. 2022

Cells

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“…The findings suggested that COS may prevent diet-induced weight gain and that the antiobesity effect is mediated partially via inhibiting adipogenesis and increasing adiponectin levels [ 77 ]. Obesity, the most common chronic metabolic disease, has been proved to induce low-grade inflammation [ 78 ]. The studies above supported the feasibility that COS with anti-inflammatory activity can be applied as a nutraceutical against metabolic diseases such as diabetes and obesity.…”

Section: Biological Activities Of Chitosan and Cosmentioning

confidence: 99%

Chitosan and Chitooligosaccharide: The Promising Non-Plant-Derived Prebiotics with Multiple Biological Activities

Guan

Feng

2022

IJMS

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Biodegradable chitin is the second-most abundant natural polysaccharide, widely existing in the exoskeletons of crabs, shrimps, insects, and the cell walls of fungi. Chitosan and chitooligosaccharide (COS, also named chitosan oligosaccharide) are the two most important deacetylated derivatives of chitin. Compared with chitin, chitosan and COS not only have more satisfactory physicochemical properties but also exhibit additional biological activities, which cause them to be widely applied in the fields of food, medicine, and agriculture. Additionally, due to their significant ability to improve gut microbiota, chitosan and COS are deemed prospective prebiotics. Here, we introduced the production, physicochemical properties, applications, and pharmacokinetic characteristics of chitosan and COS. Furthermore, we summarized the latest research on their antioxidant, anti-inflammatory, and antimicrobial activities. Research progress on the prebiotic functions of chitosan and COS is particularly reviewed. We creatively analyzed and discussed the mechanisms and correlations underlying these activities of chitosan and COS and their physicochemical properties. Our work enriched people’s understanding of these non-plant-derived prebiotics. Based on this review, the future directions of research on chitosan and COS are explored. Collectively, optimizing the production technology of chitin derivatives and enriching understanding of their biological functions will shed more light on their capability to improve human health.

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“…Particularly, a major role has been attributed to intestinal ILC2s and, to a much lesser extent, to ILC3s, while ILC1s seem to play a more relevant role in adipose tissue. ILC1s participate in the induction of inflammation and development of insulin resistance [22]. Here, the significant reduction in hepatic total lipids in the animals fed with the LMWF is unlikely to suggest the expansion of pluripotential CD117 + cells towards a cytotoxic/proinflammatory ILC1s-like phenotype.…”

Section: Discussionmentioning

confidence: 79%

Chenopodium quinoa’s Ingredients Improve Control of the Hepatic Lipid Disturbances Derived from a High-Fat Diet

Garcia Tejedor,

Haros,

Laparra Llopis

2023

Foods

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This study explored the effects of Chenopodium quinoa’s ingredients on the major lipids’ hepatic profile and the functional selective differentiation of monocyte-derived macrophages and innate lymphoid cells in mice on a high-fat diet. Six-week-old Rag2-/- and Rag2-/-Il2-/- mice received (12 days) a low-molecular-weight protein fraction (LWPF) or the lipid fraction (qLF) obtained from the cold pressing of C. quinoa’s germen. At the end of the experiment, mouse serum and liver tissue were collected. The differences in triglycerides, phospholipids, and the major lipids profile were analyzed. Infiltrated monocyte-derived macrophages and innate lymphoid cells (ILCs) and the expression of liver metabolic stress-related mRNA were measured. In the Rag2-/- mice, feeding them LWPF appeared to improve, to a larger extent, their hepatic capacity to utilize fatty acids in comparison to the qLF by preventing the overwhelming of triglycerides (TGs), despite both reducing the hepatic lipid accumulation. An analysis of the hepatic major lipids profile revealed significant increased variations in the PUFAs and phospholipid composition in the Rag2-/- mice fed with the LWPF or LF. The Rag2-/-Il2-/- mice, lacking innate and adaptive lymphocytes, seemed resistant to mobilizing hepatic TGs and unresponsive to lipid accumulation when fed with the LF. Notably, only the Rag2-/- mice fed with the LWPF showed an increased proportion of hepatic CD68+F4/80+ cells population, with a better controlled expression of the innate immune ‘Toll-like’ receptor (TLR)-4. These changes were associated with an oriented expansion of pluripotential CD117+ cells towards ILC2s (CD117+KLRG1+). Thus, C. quinoa’s ingredients resulted in being advantageous for improving the mechanisms for controlling the hepatic lipotoxicity derived from a high-fat diet, promoting liver macrophage and ILCs expansion to a selective functional differentiation for the control of HFD-driven immune and metabolic disturbances.

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Role of Innate lymphoid Cells in Obesity and Insulin Resistance

Cited by 7 publications

References 197 publications

Macrophages, Chronic Inflammation, and Insulin Resistance

Macrophages, Chronic Inflammation, and Insulin Resistance

Chitosan and Chitooligosaccharide: The Promising Non-Plant-Derived Prebiotics with Multiple Biological Activities

Chenopodium quinoa’s Ingredients Improve Control of the Hepatic Lipid Disturbances Derived from a High-Fat Diet

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