Role Of Insulin Like Growth Factor in Polycystic Ovary Syndrome

Abstract

Objectives:The polycystic ovary syndrome (PCOS) is conventionally defined as a combination of hyperandrogenism and anovulation with polycystic ovaries. Insulin-like growth factor I (IGF-I) is a 70 aa polypeptide hormone with endocrine, paracrine, and autocrine effects. it is now established that the ovary is a site of IGF-I gene expression and reception. However, this huge amount of data could be somehow distractive since different species may produce distinct IGFs (or their relative binding proteins and receptors) at different stages of follicular development. Objective: The aim of this work was to determine the serum level of IGF-I to evaluate its role in PCOS. Subjects and Methods: Twenty-five infertile women with PCOS diagnosed by ultrasound examination and a history of oligomenorrhea, hirsutism and obesity were studied. Serum levels of insulin-like growth factor-1 (IGF-1) and hormonal profile were measured. Fifteen healthy and fertile women with regular menstrual cycles served as a comparison group. Results: The serum levels of IGF-I were significantly elevated in women with PCOS compared with control and there was positive correlation between IGF-I from one side and each of BMI, W/H ratio, LH, LH/FSH ratio, TSN, T/SHBG ratio, right and left ovarian volumes. On the other side, IGF-I was inversely correlated with SHBG, right and left uterine artery PI and RI. Conclusion: The significant finding of this study is that PCOS patients have increased circulating IGF-I levels than healthy controls and it can be used as a biochemical marker for PCOS.

Assessment of Symptoms, Pregnancy Outcome, and Health-Related Quality of Life among PCOS women Treated with Myo inositol and Metformin

“…[22] Health-Related Quality of life Questionnaire (HRQOL) Health-Related Quality of life Questionnaire for PCOS patients had evaluated using the English version of Cronin et al 23, and then translated into Arabic language by researcher to evaluate PCOS women and determines the physical and psychological aspects of life quality. This questionnaire sheet to evaluate PCOS women composed of 26 questions, which reduced and categorized into 5 sections to include: body hair (5), weight (5), emotion (6), infertility (5), and menstrual problems (5). Each response is given a seven-point Likert scale, with seven denoting the best scenario and one denoting the worst.24 This questionnaire were taken at baseline and after 3 months of treatment.…”

“…[2] According to the Rotterdam criteria, polycystic ovaries, oligo-or anovulation, and clinical and/or biochemical hyperandrogenism are three of the important components that must be present in women for PCOS to be diagnosed. [3] The aetiology of PCOS is thought to be significantly influenced by insulin resistance and compensatory hyperinsulinemia, both of which are more prevalent in both lean and overweight women [4] .Although the cellular and molecular processes of insulin resistance in PCOS have not yet been fully understood, they are thought to differ from those of other disorders linked to insulin resistance [5] Insulin resistance in PCOS approximately from 50% to 80% with severe PCOS and obesity being the most common cases [6] . Due to IR, these women are more susceptible to developing type 2 diabetes, hypertension, dyslipidaemia, cancer, and CVDs [7] , as well as PCOS associated with dermatological issues linked to an increase in plasma testosterone levels that cause hirsutism, acne-related alopecia [8] .It is notable that IR improvement and circulating insulin decrease are important treatment targets in PCOS.…”