Role of Interleukin-1 family in bone metastasis of prostate cancer

Tong, Yuanhao; Cao, Yinghao; Jin, Tianzhe; Huang, Zhengwei; He, Qinyuan; Mao, Min

doi:10.3389/fonc.2022.951167

Cited by 11 publications

(7 citation statements)

References 113 publications

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“…Analogous results were obtained in prostate cancer models, in which the overexpression of IL-1β increased bone metastasis [54,58].…”

Section: Il1 Family In Bone Metastasissupporting

confidence: 71%

“…Bone metastasis occurs when cancer cells from primary tumors, such as breast, prostate, lung, and bone tumors, or other malignancies, spread to the bone. This process involves a complex interplay of various molecular and cellular factors, and emerging evidence suggests that IL-1 is actively involved in several mechanisms of this metastatic cascade [27,[54][55][56].…”

Section: Il1 Family In Bone Metastasismentioning

confidence: 99%

“…Human prostate cancer (PCa) cells secreting IL-1β can convert the bone stroma into a metastatic niche by upregulating genes such as S100A4 and COX-2, which are involved in the formation of cancer-associated fibroblasts (CAFs). Several studies have reported that CAFs can be impaired by anakinra, resulting in a reduction in the tumor burden and bone metastasis [54,59].…”

Section: Il1 Family In Bone Metastasismentioning

confidence: 99%

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IL-1 Family Members in Bone Sarcomas

Landuzzi,

Ruzzi,

Pellegrini

et al. 2024

Cells

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IL-1 family members have multiple pleiotropic functions affecting various tissues and cells, including the regulation of the immune response, hematopoietic homeostasis, bone remodeling, neuronal physiology, and synaptic plasticity. Many of these activities are involved in various pathological processes and immunological disorders, including tumor initiation and progression. Indeed, IL-1 family members have been described to contribute to shaping the tumor microenvironment (TME), determining immune evasion and drug resistance, and to sustain tumor aggressiveness and metastasis. This review addresses the role of IL-1 family members in bone sarcomas, particularly the highly metastatic osteosarcoma (OS) and Ewing sarcoma (EWS), and discusses the IL-1-family-related mechanisms that play a role in bone metastasis development. We also consider the therapeutic implications of targeting IL-1 family members, which have been proposed as (i) relevant targets for anti-tumor and anti-metastatic drugs; (ii) immune checkpoints for immune suppression; and (iii) potential antigens for immunotherapy.

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“…Analogous results were obtained in prostate cancer models, in which the overexpression of IL-1β increased bone metastasis [54,58].…”

Section: Il1 Family In Bone Metastasissupporting

confidence: 71%

Section: Il1 Family In Bone Metastasismentioning

confidence: 99%

Section: Il1 Family In Bone Metastasismentioning

confidence: 99%

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IL-1 Family Members in Bone Sarcomas

Landuzzi,

Ruzzi,

Pellegrini

et al. 2024

Cells

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“…In vitro studies have shown that progenitors of MAFs become activated when treated with a conditioned medium from tumour cells [ 13 , 43 , 44 ]. Of the myriad of soluble factors identified from the secretome of cancer cells, ligands belonging to the TGF-β superfamily [ 45 , 46 ], platelet-derived growth factors (PDGFs) [ 47 ], inflammatory cytokines, and chemokines such as interleukins (IL) [ 48 ], and more recently, exosomes and macrovesicles [ 49 ] have been implicated in this transformative process. While both PC3 and MDA-Pca 2b cells were originally isolated from bone metastases, their secretome profiles are diverse.…”

Section: Discussionmentioning

confidence: 99%

Induction of Reactive Bone Stromal Fibroblasts in 3D Models of Prostate Cancer Bone Metastases

Windus

Matigian

Avery

2023

Biology

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A dynamic interplay between prostate cancer (PCa) cells and reactive bone stroma modulates the growth of metastases within the bone microenvironment. Of the stromal cells, metastasis-associated fibroblasts (MAFs) are known to contribute but are the least studied cell type in PCa tumour progression. It is the aim of the current study to establish a biologically relevant 3D in vitro model that mimics the cellular and molecular profiles of MAFs found in vivo. Using 3D in vitro cell culture models, the bone-derived fibroblast cell line, HS-5, was treated with conditioned media from metastatic-derived PCa cell lines, PC3 and MDA-PCa 2b, or mouse-derived fibroblasts 3T3. Two corresponding reactive cell lines were propagated: HS5-PC3 and HS5-MDA, and evaluated for alterations in morphology, phenotype, cellular behaviour, plus protein and genomic profiles. HS5-PC3 and HS5-MDA displayed distinct alterations in expression levels of N-Cadherin, non-functional E-Cadherin, alpha-smooth muscle actin (α-SMA), Tenascin C, and vimentin, along with transforming growth factor receptor expression (TGF β R1 and R2), consistent with subpopulations of MAFs reported in vivo. Transcriptomic analysis revealed a reversion of HS5-PC3 towards a metastatic phenotype with an upregulation in pathways known to regulate cancer invasion, proliferation, and angiogenesis. The exploitation of these engineered 3D models could help further unravel the novel biology regulating metastatic growth and the role fibroblasts play in the colonisation process.

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“…In contrast, IL-1β plays an important role in the inflammatory cascade by promoting the recruitment of inflammatory cells and increasing the production of other cytokines. These cytokines have a key effect on the progression of bone metastasis and many types of cancers ( 69 ). Multiple pieces of evidence have demonstrated that inflammation can stimulate bone metastasis through different mechanisms.…”

Section: Discussionmentioning

confidence: 99%

Role of bone marrow adipocytes in bone metastasis development and progression: a systematic review

Salamanna,

Contartese,

Errani

et al. 2023

Front. Endocrinol.

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PurposeBone marrow adipocytes (BMAs) are the most plentiful cells in the bone marrow and function as an endocrine organ by producing fatty acids, cytokines, and adipokines. Consequently, BMAs can interact with tumor cells, influencing both tumor growth and the onset and progression of bone metastasis. This review aims to systematically evaluate the role of BMAs in the development and progression of bone metastasis.MethodsA comprehensive search was conducted on PubMed, Web of Science, and Scopus electronic databases, following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement standards, to identify studies published from March 2013 to June 2023. Two independent reviewers assessed and screened the literature, extracted the data, and evaluated the quality of the studies. The body of evidence was evaluated and graded using the ROBINS-I tool for non-randomized studies of interventions and the Systematic Review Centre for Laboratory Animal Experimentation (SYRCLE) tool for in vivo studies. The results were synthesized using descriptive methods.ResultsThe search yielded a total of 463 studies, of which 17 studies were included in the final analysis, including 15 preclinical studies and two non-randomized clinical studies. Analysis of preclinical studies revealed that BMAs play a significant role in bone metastasis, particularly in prostate cancer followed by breast and malignant melanoma cancers. BMAs primarily influence cancer cells by inducing a glycolytic phenotype and releasing or upregulating soluble factors, chemokines, cytokines, adipokines, tumor-derived fatty acid-binding protein (FABP), and members of the nuclear receptor superfamily, such as chemokine (C-C motif) ligand 7 (CCL7), C-X-C Motif Chemokine Ligand (CXCL)1, CXCL2, interleukin (IL)-1β, IL-6, FABP4, and peroxisome proliferator-activated receptor γ (PPARγ). These factors also contribute to adipocyte lipolysis and regulate a pro-inflammatory phenotype in BMAs. However, the number of clinical studies is limited, and definitive conclusions cannot be drawn.ConclusionThe preclinical studies reviewed indicate that BMAs may play a crucial role in bone metastasis in prostate, breast, and malignant melanoma cancers. Nevertheless, further preclinical and clinical studies are needed to better understand the complex role and relationship between BMAs and cancer cells in the bone microenvironment. Targeting BMAs in combination with standard treatments holds promise as a potential therapeutic strategy for bone metastasis.

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Role of Interleukin-1 family in bone metastasis of prostate cancer

Cited by 11 publications

References 113 publications

IL-1 Family Members in Bone Sarcomas

IL-1 Family Members in Bone Sarcomas

Induction of Reactive Bone Stromal Fibroblasts in 3D Models of Prostate Cancer Bone Metastases

Role of bone marrow adipocytes in bone metastasis development and progression: a systematic review

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