Role of Interleukin 37 as a Novel Proangiogenic Factor in Juvenile Idiopathic Arthritis

El-Barbary, Amal Mohamad; Hussein, Manal Shawky; Almedany, S.; Rageh, Elsayed Mohamad; Alsalawy, Alaa Mohamed; Aboelhawa, Marwa Ahmed; Elkholy, Radwa Mostafa; Shafik, Noha M.; Elharoun, Ahmed S

doi:10.1097/rhu.0000000000000779

Cited by 9 publications

(5 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Recent data indicated that IL-37 expression was significantly elevated in plasma, PBMCs and synovial fluid (SF) in JIA patients [ 23 ]. Consistent with the findings, our results also revealed that plasma IL-37 levels were higher in sJIA patients compared with HCs.…”

Section: Discussionmentioning

confidence: 99%

“…The monitoring of sJIA disease activity is traditionally based on clinical observations and laboratory features, such as JADAS-27, CRP, ESR, PLT and so on [ 23 , 30 , 31 ]. We further analyzed the relationship between IL-37 expression and several laboratory values.…”

Section: Discussionmentioning

confidence: 99%

“…Concomitantly, IL-37 can inhibit the production of pro-inflammatory cytokines in PBMCs from subjects with SLE, RA, AS and AOSD in vitro. As yet, only one study investigated IL-37 levels in the serum and synovial fluid of JIA patients and demonstrated the positive correlation with disease activity and markers of angiogenesis [ 23 ]. Although the IL-37 levels and IL-37 mRNA expression have been reported to be elevated in JIA patients, especially in sJIA patients, when compared with the healthy subjects, its relationships with other disease manifestations and pro-inflammatory cytokines are still unknown.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Plasma interleukin-37 is increased and inhibits the production of inflammatory cytokines in peripheral blood mononuclear cells in systemic juvenile idiopathic arthritis patients

Mao

Kang

et al. 2018

J Transl Med

View full text Add to dashboard Cite

BackgroundInterleukin (IL)-37 has emerged as a novel anti-inflammatory cytokine that play an immunosuppressive role in regulating inflammatory response. This study aimed to measure IL-37 levels in the plasma and peripheral blood mononuclear cells (PBMCs) of patients with systemic juvenile idiopathic arthritis (sJIA), and to establish the correlation between IL-37 levels and disease activity, laboratory parameters and inflammatory cytokines.MethodsThe mRNA levels of IL-37 in PBMCs and plasma IL-37 concentrations in 46 sJIA patients and 30 age- and sex-matched healthy controls were measured by real-time polymerase chain reaction (RT-PCR) and enzyme-linked immunosorbent assay (ELISA), respectively. The correlations between plasma IL-37 levels and disease activity, laboratory parameters and inflammatory cytokines in sJIA were analyzed by Spearman correlation test. PBMCs from the sJIA patients were stimulated with recombinant human IL-37 (rhIL-37) protein, expressions of IL-1β, IL-6, TNF-α and IL-17 were detected by RT-PCR and ELISA.ResultsPlasma levels of IL-37 and relative IL-37 mRNA expression were significantly elevated in sJIA patients, especially in active sJIA patients, when compared with the healthy controls (P < 0.001). Furthermore, patients with active disease showed higher IL-37 mRNAs and plasma protein levels than those with inactive disease as well as healthy controls. Plasma IL-37 levels were correlated with disease activity and inflammatory cytokines (IL-6, TNF-α, IL-17 and GM-CSF) in sJIA patients. The productions of inflammatory cytokines such as IL-6, TNF-α, IL-17 in PBMCs from sJIA patients were obviously decreased after recombinant IL-37 stimulation, whereas the production of IL-1β was not changed.ConclusionsOur results demonstrate that levels of IL-37 were higher in sJIA patients, which were correlated with disease activity and sJIA related inflammatory cytokines. In addition, rhIL-37 down-regulates the expressions of inflammatory cytokines form PBMCs in sJIA patients, suggesting that IL-37 may have the potential role as a natural inhibitor for the pathogenesis and therapy of sJIA.Electronic supplementary materialThe online version of this article (10.1186/s12967-018-1655-8) contains supplementary material, which is available to authorized users.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Plasma interleukin-37 is increased and inhibits the production of inflammatory cytokines in peripheral blood mononuclear cells in systemic juvenile idiopathic arthritis patients

Mao

Kang

et al. 2018

J Transl Med

View full text Add to dashboard Cite

show abstract

“…The authors of this study report that following IL-37 treatment in a monkey chorioretinal vessel endothelial cell line (RF/6A), tube formation and branching points were increased (85.3 and 71.4%, respectively) along with cell proliferation, compared to PBS controls (47). IL-37 has been suggested to have pro-angiogenic roles similar to IL-18 in other diseases (158, 159), able to signal through the IL-18Ra.…”

Section: Diabetic Retinopathymentioning

confidence: 99%

IL-1 Family Members Mediate Cell Death, Inflammation and Angiogenesis in Retinal Degenerative Diseases

et al. 2019

View full text Add to dashboard Cite

Inflammation underpins and contributes to the pathogenesis of many retinal degenerative diseases. The recruitment and activation of both resident microglia and recruited macrophages, as well as the production of cytokines, are key contributing factors for progressive cell death in these diseases. In particular, the interleukin 1 (IL-1) family consisting of both pro- and anti-inflammatory cytokines has been shown to be pivotal in the mediation of innate immunity and contribute directly to a number of retinal degenerations, including Age-Related Macular Degeneration (AMD), diabetic retinopathy, retinitis pigmentosa, glaucoma, and retinopathy of prematurity (ROP). In this review, we will discuss the role of IL-1 family members and inflammasome signaling in retinal degenerative diseases, piecing together their contribution to retinal disease pathology, and identifying areas of research expansion required to further elucidate their function in the retina.

show abstract

“…It has been shown that IL-37 affects the activity and phenotype of DCs and suppresses the inflammatory responses mediated by Th17 and IL-17 in RA, while failing to inhibit Th-17 cell differentiation ( 24 ). In a study involving 70 patients with juvenile idiopathic arthritis (JIA), serum/synovial IL-37 levels and IL-37 mRNA expression in PBMCs were positively associated with disease activity and angiogenesis indicators [including vascular endothelial growth factor (VEGF) and VEGF receptors] ( 56 ).…”

Section: Il-37 and Aidsmentioning

confidence: 99%

Biology of interleukin‑37 and its role in autoimmune diseases (Review)

Zeng¹,

Zhou

Ye³

2022

Exp Ther Med

View full text Add to dashboard Cite

Autoimmune diseases (AIDs) are characterized by dysfunction and tissue destruction, and recent studies have shown that interleukin (IL)-37 expression is dysregulated in AIDs. Among cytokines of the IL-1 family, most are pro-inflammatory agents, and as an anti-inflammatory cytokine, IL-37 may have the potential to alleviate excessive inflammation and can be used as a ligand or transcription factor that is involved in regulating innate and adaptive immunity. IL-37 plays important roles in the development of AIDs. This review summarizes the biological characteristics and functions of IL-37 and discusses the potential of IL-37 as a therapeutic target for effective cytokine therapy and as a biomarker in AIDs.

show abstract

Role of Interleukin 37 as a Novel Proangiogenic Factor in Juvenile Idiopathic Arthritis

Abstract: Our results demonstrate that IL-37 levels and mRNA expression were significantly increased in JIA patients, and their levels were positively correlated with disease activity and markers of angiogenesis (VEGF and VEGF receptors), suggesting that IL-37 may be correlated with angiogenesis.

Cited by 9 publications

References 29 publications

Plasma interleukin-37 is increased and inhibits the production of inflammatory cytokines in peripheral blood mononuclear cells in systemic juvenile idiopathic arthritis patients

Plasma interleukin-37 is increased and inhibits the production of inflammatory cytokines in peripheral blood mononuclear cells in systemic juvenile idiopathic arthritis patients

IL-1 Family Members Mediate Cell Death, Inflammation and Angiogenesis in Retinal Degenerative Diseases

Biology of interleukin‑37 and its role in autoimmune diseases (Review)

Contact Info

Product

Resources

About