Role of interleukin-4 genetic polymorphisms and environmental factors in the risk of asthma in children

Li, L.; Li, Y.; Zeng, Xiaona; Li, J.; Du, Xialin

doi:10.4238/gmr15048873

Cited by 15 publications

(8 citation statements)

References 32 publications

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“…Massoud et al proposed as underlying mechanism the conversion of induced regulatory T cells toward Th17 cell inflammation driven by altered IL4R function [ 117 ]. Studies on children population reported a significant association of ILR4A polymorphisms and asthma susceptibility [ 118 ], although a more specific predisposition to asthma exacerbation risk needs to be evaluated in these patients.…”

Section: Genetic and Transcriptomic Predispositionmentioning

confidence: 99%

The Predictive Role of Biomarkers and Genetics in Childhood Asthma Exacerbations

Palmo

Cantarelli

Catelli

et al. 2021

IJMS

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Asthma exacerbations are associated with significant childhood morbidity and mortality. Recurrent asthma attacks contribute to progressive loss of lung function and can sometimes be fatal or near-fatal, even in mild asthma. Exacerbation prevention becomes a primary target in the management of all asthmatic patients. Our work reviews current advances on exacerbation predictive factors, focusing on the role of non-invasive biomarkers and genetics in order to identify subjects at higher risk of asthma attacks. Easy-to-perform tests are necessary in children; therefore, interest has increased on samples like exhaled breath condensate, urine and saliva. The variability of biomarker levels suggests the use of seriate measurements and composite markers. Genetic predisposition to childhood asthma onset has been largely investigated. Recent studies highlighted the influence of single nucleotide polymorphisms even on exacerbation susceptibility, through involvement of both intrinsic mechanisms and gene-environment interaction. The role of molecular and genetic aspects in exacerbation prediction supports an individual-shaped approach, in which follow-up planning and therapy optimization take into account not only the severity degree, but also the risk of recurrent exacerbations. Further efforts should be made to improve and validate the application of biomarkers and genomics in clinical settings.

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Section: Genetic and Transcriptomic Predispositionmentioning

confidence: 99%

The Predictive Role of Biomarkers and Genetics in Childhood Asthma Exacerbations

Palmo

Cantarelli

Catelli

et al. 2021

IJMS

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“…Overall, 55 studies with 9572 cases and 9881 controls included in quantitative analysis of the association between IL-4 gene -589C/T polymorphism and the risk of asthma. Of those, 11 articles were conducted in European countries [ 29 , 31 , 33 , 38 – 41 , 55 , 63 , 64 , 69 ], 32 articles were in Asian countries [ 27 , 30 , 32 , 34 – 37 , 43 – 46 , 49 , 50 , 53 , 54 , 56 – 62 , 65 , 66 , 68 , 70 – 73 ], 10 articles in American countries [ 16 , 26 , 28 , 42 , 48 , 52 ] and one article in each Algeria [ 67 ] and Australia country [ 51 ]. The analysis of overall population revealed the significant positive association between IL4 gene -589C/T polymorphism and the risk of asthma across all genetic models; including dominant model (OR = 1.22, 95% CI = 1.04–1.44, P = 0.01, REM), recessive model (OR = 1.17, 95% CI = 1.08–1.27, P < 0.001, FEM), allelic model (OR = 1.21, 95% CI = 1.09–1.33, P < 0.001, REM), and TT vs. CC model (OR = 1.34, 95% CI = 1.18–1.52, P < 0.001, FEM), except CT vs. TT model (OR = 1.13, 95% CI = 0.95–1.34, P = 0.17, REM) (Fig.…”

Section: Resultsmentioning

confidence: 99%

Interleukin 4 gene polymorphism (−589C/T) and the risk of asthma: a meta-analysis and met-regression based on 55 studies

et al. 2020

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Background Numerous investigations have previously evaluated the association of interleukin (IL) 4 gene polymorphisms and the risk of asthma, conferring inconsistent results. To resolve the incongruent outcomes yielded from different single studies, we conducted the most up-to-date meta-analysis of IL4 gene −589C/T (rs2243250) polymorphism and susceptibility to asthma. Methods A systematic literature search was performed in ISI web of science, Scopus, Medline/PubMed databases prior to September 2020, and the pooled odds ratio (OR) and their corresponding 95% CI were calculated to determine the association strength. Results Literature search led to retrieving of 49 publications (55 case-control studies) containing 9572 cases and 9881 controls. It was revealed that IL4 gene −589C/T polymorphism increased the risk of asthma across all genetic models, including dominant model (OR = 1.22), recessive model (OR = 1.17), allelic model (OR = 1.21), and TT vs. CC model (OR = 1.34), but not the CT vs. TT model. The subgroup analysis by age indicated that IL4 gene -589C/T polymorphism was significantly associated with asthma risk in both pediatrics and adults. Additionally, the subgroup analysis by ethnicity revealed significant association in Asian, American, and Europeans. Finally, subgroup analysis by East Asian and non-East Asian populations indicated significant associations. Conclusions The current meta-analysis revealed that IL4 gene -589C/T polymorphism was a susceptibility risk in both pediatrics and adults in the whole and different ethnic groups.

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“…8 Estudios anteriores indicaron que la IL-4 y su variante polimórfica de receptores aumentaban el riesgo de asma al interactuar con la exposición al humo y las mascotas. 9 La patogenia de las enfermedades alérgicas que involucran múltiples citocinas, quimiocinas y sus correlaciones analizadas como la base de la terapia de fase efectora, como anti-IgE, esteroides, miméticos β2, antagonistas del receptor de leucotrienos. 7 La IL-4 son citocinas, fundamentales y desempeñan un papel esencial en el desarrollo de la alergia.…”

Section: Introductionunclassified

“…7 La IL-4 son citocinas, fundamentales y desempeñan un papel esencial en el desarrollo de la alergia. 9 La alteración de estos genes puede dar lugar a diferentes respuestas a diversas sustancias sensibilizantes. 10 C-590 T es un polimorfismo promotor de IL-4 que influye en la transcripción de varios genes de citocinas.…”

Section: Introductionunclassified

Correlation between interleukin 4 (IL-4) expression and allergen sensitization in allergic rhinitis patients

Widuri

2021

RAM

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Objective: The objective of this research was to measure the correlation of the expression of IL-4 with allergen sensitization in patients with allergic rhinitis. Methods: Descriptive analytics was used as a method in this research, with a cross-sectional approach. The subjects were 37 persons with allergic rhinitis who met the inclusion and exclusion criteria. This research was conducted in patients with clinical manifestations of symptoms of allergic rhinitis, and skin prick tests were carried out with ten types of allergens, which are: house dust, cotton, chicken feathers, shrimp, tuna, chicken egg-yolk, chicken egg-white, peanuts, tea, and chocolate. Venous blood sampling was performed for the Interleukin-4 (IL-4) test by using an ELISA device. Results: The respondents were 37 patients with allergic rhinitis, of which 26 (70.3 %) were women and 11 (29.7 %) were men. The highest sensitivity to inhaled allergens in patients with rhinitis was to house dust in 31 samples (83.8 %). The correlation of the expression of IL-4 with sensitization to allergens in patients with allergic rhinitis based on the Spearman test resulted in p > 0.05, not significant with some allergens in a negative correlation. Conclusion: There was no significant correlation between the expression of IL-4 and the sensitization to allergens in patients with allergic rhinitis.

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Role of interleukin-4 genetic polymorphisms and environmental factors in the risk of asthma in children

Cited by 15 publications

References 32 publications

The Predictive Role of Biomarkers and Genetics in Childhood Asthma Exacerbations

The Predictive Role of Biomarkers and Genetics in Childhood Asthma Exacerbations

Interleukin 4 gene polymorphism (−589C/T) and the risk of asthma: a meta-analysis and met-regression based on 55 studies

Correlation between interleukin 4 (IL-4) expression and allergen sensitization in allergic rhinitis patients

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