Role of interleukin 6 and highly sensitive C-reactive protein in diabetic nephropathy

Abstract

The pathogenesis of diabetic nephropathy (DN) is still incompletely understood. Few studies have linked the cellular inflammatory markers, interleukin 6 (IL-6) and highly sensitive C-reactive protein (hs-CRP), to the development of DN. AimWe aimed to explore the link among IL-6, hs-CRP, and grades of DN in both types of diabetes mellitus (DM). Settings and designWe carried out a case-control study on participants selected from the outpatient clinic of Internal Medicine Department. Patients and methodsWe worked on 91 participants, comprising 78 patients and 13 controls. The patient group was further subdivided into two subgroups: subgroup I [39 patients type 1 DM (T1DM)] and subgroup II [39 patients type 2 DM (T2DM)]. Each subgroup was categorized according to the urinary albumin excretion rate into three divisions: A (<20 μg/min), B (20-200 μg/min), and C (>200 μg/min). We applied history taking, clinical examination, routine investigation, and IL-6 with hs-CRP testing to all participants. Statistical analysisWe used Shapiro-Wilk test, χ 2 test, Student's t test, one-way analysis of variance, Kruskal-Wallis test, least significant difference test, and Pearson's correlation coefficient for data analysis. ResultsDespite the significant difference of laboratory data between patient and control groups, least significant difference analysis revealed a nonsignificant difference between patients with T1DM and those with T2DM. On the level of the in-groups analysis, the most significant key players were hs-CRP and IL-6 among the three urinary albumin excretion rate categories of patients with T1DM and T2DM, with P values less than 0.01. ConclusionsWe concluded that IL-6 and hs-CRP might be used as sensitive markers for the development of DN.

Pro-inflammatory cytokines in patients with chronic kidney disease: interleukin-6 in focus

“…Полагают, что чувствительность этих двух видов рецепторов довольно высокая (0,5 -2,0 нМ) и практически одинаковая [22,23]. Установлено, что повышение содержание ИЛ-6 наблюдается при ожирении и СД 2-го типа [24]. Если принять во внимание этот факт, то в нашем исследовании доля больных с повышенным весом и СД 2-го типа была довольно многочисленной.…”