Role of Interleukin-6 and Procalcitonin as Inflammatory Biomarkers in Evaluating Covid-19 Disease Severity on HRCT Chestan Experience at CMH Quetta

Ayub, Zeeshan; Ahmed, Azeema; Afzal, Farah; Bashir, Saima; Iqbal, Hamid; Nawaz, Khurram Haq

doi:10.51253/pafmj.v71i6.6977

PAFMJ

2021

DOI: 10.51253/pafmj.v71i6.6977

|View full text |Cite

Role of Interleukin-6 and Procalcitonin as Inflammatory Biomarkers in Evaluating Covid-19 Disease Severity on HRCT Chestan Experience at CMH Quetta

Zeeshan Ayub

Azeema Ahmed

Farah Afzal

et al.

Abstract: Objective: To explore the relation of Interleukin-6 and Procalcitonin with COVID-19 severity on high resolution computerized tomogram (HRCT) chest. Study Design: Randomized Control Trial (NCT04945811). Place and Duration of study: Pathology Department, Combined Military Hospital Quetta, from April 2020 to May 2021. Methodology: Serum Interleukin-6 and Procalcitonin of 100 consenting COVID-19 positive patients from April 2020 to May 2021 were assessed at Pathology department Combined Military … Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2023

2024

Publication Types

Select...

Article2

Relationship

Self Cite0

Independent2

Authors

Journals

Cited by 2 publications

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

A study on diagnostic and prognostic significance of laboratory parameters and its correlation with HRCT of lung in Covid-19 patients

Agarwal¹,

Meena

Sαxena³

et al. 2023

ACHR

View full text Add to dashboard Cite

Coronaviruses had a wide range of symptoms from asymptomatic to severe illness and has caused significant morbidity and death among large population infected with this virus. To correlate CT severity score with each blood parameter like (TLC counts, Absolute neutrophil count, Absolute lymphocyte count, neutrophilic/lymphocytic ratio, quantitative D-dimer, ferritin, CRP, IL-6 and LDH). To assess diagnostic and prognostic significance of each parameter in predicting severity of disease.The present study was a 1-year prospective, a hospital-based study from 1 August 2020 to 31 July 2021 and included 100, COVID-19 confirmed cases. The clinical, radiological and laboratory reports were collected. The CT score were compared with different blood parameters. The results were analyzed statistically using correlation coefficient(r).27 patients having a CT severity score 1-10 were graded in mild category. 27 patients having CT severity score 11-15 were graded in moderate category.34 patients having CT severity score 16- 20 were graded as severe.12 patients having CT severity score 21-25 were graded as very severe. The present study showed raised TLC count > 11000 / µl in 35% patients suffering from COVID -19. Absolute neutrophil count > 7000/µl was seen in 50 % patients. 65% patients showed Absolute lymphocyte count <1000> 3.5 was seen in 83% patients. Raised D-Dimer >500 ng/ml was observed in 74 % patients. 92 % subjects showed raised Serum ferritin >150ng/ml. IL-6 >10pg/ml was seen in 92 % patients. Q-CRP >10 mg/l was seen in 97 % patients.HRCT chest severity score of patients with COVID-19 has positive correlation with various laboratory parameters and hence can be used as an indicator of disease severity. It can play a vital role in the management of COVID-19 and should be used for comprehensive evaluation.

show abstract

A study on diagnostic and prognostic significance of laboratory parameters and its correlation with HRCT of lung in Covid-19 patients

Agarwal¹,

Meena

Sαxena³

et al. 2023

ACHR

View full text Add to dashboard Cite

show abstract

Role of Inflammatory Markers in Severity, ICU Admission, and Mortality in COVID-19: A Systematic Review and Meta-analysis of 79,934 Patients

Hiwa O. Abdullah,

Sadraldin A. Braim,

Maria A. Rasool

et al. 2024

Barw Medical Journal

View full text Add to dashboard Cite

Introduction Despite extensive investigations into the roles of inflammatory biomarkers in the prognosis of COVID-19 through systematic reviews and meta-analyses, they are limited by small sample sizes and focus on a specific marker. This meta-analysis investigated the role of 11 inflammatory biomarkers in severity, intensive care unit (ICU) admission, and mortality among COVID-19 patients. Methods Studies up to October 25, 2023, were identified through a search of Google Scholar, limited to human studies published in English. Inclusion criteria required confirmed COVID-19 cases diagnosed via reliable laboratory methods, original articles from eligible journals, proper grouping of severity status, ICU admission, or mortality outcomes, and presentation of continuous data in mean and standard deviation, median with range, or interquartile range. Results A total of 241 studies, comprising 79,934 cases of COVID-19, were included in this study. Albumin levels significantly declined in severe, ICU, and dead cases compared to mild, moderate, non-ICU, and survived cases (p<0.001). C-reactive protein (CRP), D-dimer, erythrocyte sedimentation rate (ESR), ferritin, fibrinogen, Interleukin-6 (IL-6), lactate dehydrogenase (LDH), neutrophil-to-lymphocyte ratio (NLR), procalcitonin, and white blood cell (WBC) were all significantly (p<0.001) increased and correlated with the severity of COVID-19. CRP, D-dimer, ferritin, fibrinogen, IL-6, LDH, NLR, procalcitonin, and WBC were all significantly (p<0.05) elevated and correlated with the risk of ICU admission (except fibrinogen) and mortality in COVID-19 in both fixed and random effects. Conclusion Inflammatory biomarkers like albumin, CRP, D-dimer, ferritin, IL-6, LDH, NLR, procalcitonin, and WBC all significantly impact severity status, ICU admission, and mortality in COVID-19.

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Role of Interleukin-6 and Procalcitonin as Inflammatory Biomarkers in Evaluating Covid-19 Disease Severity on HRCT Chestan Experience at CMH Quetta

Cited by 2 publications

References 18 publications

A study on diagnostic and prognostic significance of laboratory parameters and its correlation with HRCT of lung in Covid-19 patients

A study on diagnostic and prognostic significance of laboratory parameters and its correlation with HRCT of lung in Covid-19 patients

Role of Inflammatory Markers in Severity, ICU Admission, and Mortality in COVID-19: A Systematic Review and Meta-analysis of 79,934 Patients

Contact Info

Product

Resources

About