Role of interleukin-6 in diabetic foot ulcers patients in Thi-Qar Provence

Abstract

The aim of this study is to evaluate the level of Interleukin-6 in patient with diabetic foot ulcers. The present study was carried out in the Diabetes and Endocrinology Center of the Health Directorate at Thi-Qar Provence, at the period between January to July (2022). The immune status investigates for patients with diabetic foot ulcers by measuring the levels of Interleukin-6 (IL-6) in serum using a technique enzyme-linked immune Sorbent adsorptive (ELISA). The study included 100 subjects, (50) patients with diabetic foot and (50) were healthy control. The statistical analysis showed that a high significant increase (P≤0.01) in serum the rate of concentration of (IL-6) in patients (6.16 ± 5.24) pg/ml compared to the healthy control group (5.42 ± 7.74) pg/ml with significant difference (0.01). These results revealed that the excessive presence of (IL-6) might play a role in Thi-Qar Provence population.

Recent Advances in Biomolecular Patho-Mechanistic Pathways behind the Development and Progression of Diabetic Neuropathy

“…STZinduced DM rats showed an increase in pro-inflammatory cytokines, such as IL-1 and IL-6, in the spinal cord [194]. Furthermore, it has been discovered that diabetic individuals with foot ulcers and those exhibiting a high association with fibrinogen and C-reactive protein (CRP) overexpressed IL-6 [195,196].…”