Role of interleukin-6 to differentiate sepsis from non-infectious systemic inflammatory response syndrome

Ma, Li; Zhang, Hui; Yin, Yanling; Guo, Wenzhi; Ma, Yaqun; Wang, Yübo; Shu, Cheng; Dong, Lian-qiang

doi:10.1016/j.cyto.2016.08.033

Cited by 106 publications

(87 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…34 However, the prognostic values of IL-6 are controversial due to the short window in which IL-6 rises and falls during in ammation and infection. 35 The SAPS-2 score was also used in combination with suPAR by Kofoed et al 14 , resulting in an AUC of 0.930, which was the second highest AUC we found in our study. These ndings suggest that the SAPS-2 is a clinical scoring system with a high diagnostic accuracy on 30-day mortality, although it has not been validated for assessing severity of disease in the ED.…”

Section: Discussionsupporting

confidence: 60%

Predicting mortality in patients with sepsis in the emergency department by using combinations of biomarkers and clinical scoring systems: a systematic review.

Tong‐Minh¹,

Welten²,

Endeman³

et al. 2020

Preprint

View full text Add to dashboard Cite

Introduction Sepsis can be detected in an early stage in the emergency department (ED) by biomarkers and clinical scoring systems. A combination of multiple biomarkers or biomarker with clinical scoring system might result in a higher predictive value on mortality. The goal of this systematic review is to evaluate the available literature on combinations of biomarkers and clinical scoring systems on 1-month mortality in patients with sepsis in the ED.Methods We performed a systematic search using MEDLINE, PubMed, EMBASE and Google Scholar. Articles were included if they evaluated at least one biomarker combined with another biomarker or clinical scoring system and reported the diagnostic accuracy on 28 or 30 day mortality by area under the curve (AUC) in patients with sepsis. Results We found 18 articles in this systematic review. In these 18 articles, a total of 35 combinations of biomarkers and clinical scoring systems were studied of which 33 unique combinations. In total, seven different clinical scoring systems and 21 different biomarkers were investigated. The combination of procalcitonin (PCT), lactate, interleukin-6 (IL-6) and Simplified Acute Physiology Score-2 (SAPS-2) resulted in the highest AUC on 1-month mortality. Conclusion In this systematic review, the combination of PCT, IL-6, lactate and the SAPS-2 score had the highest AUC on 1-month mortality in patients with sepsis in the ED. The studies we found in this review were too heterogeneous to conclude that a certain combination it should be used in the ED to predict 1-month mortality in patients with sepsis.

show abstract

Section: Discussionsupporting

confidence: 60%

Predicting mortality in patients with sepsis in the emergency department by using combinations of biomarkers and clinical scoring systems: a systematic review.

Tong‐Minh¹,

Welten²,

Endeman³

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…These findings support its potential use as a confirmatory test rather than its use to exclude the diagnosis of sepsis. 70 …”

Section: Sepsis In Burn Patients: Diagnostic and Prognostic Toolsmentioning

confidence: 99%

Predicting and managing sepsis in burn patients: current perspectives

Lopez¹,

Cambiaso‐Daniel²,

Branski³

et al. 2017

TCRM

View full text Add to dashboard Cite

Modern burn care has led to unprecedented survival rates in burn patients whose injuries were fatal a few decades ago. Along with improved survival, new challenges have emerged in the management of burn patients. Infections top the list of the most common complication after burns, and sepsis is the leading cause of death in both adult and pediatric burn patients. The diagnosis and management of sepsis in burns is complex as a tremendous hypermetabolic response secondary to burn injury can be superimposed on systemic infection, leading to organ dysfunction. The management of a septic burn patient represents a challenging scenario that is commonly encountered by providers caring for burn patients despite preventive efforts. Here, we discuss the current perspectives in the diagnosis and treatment of sepsis and septic shock in burn patients.

show abstract

“…Their role as prognostic markers, as well as causative factors in the pathophysiology of the disease entities of sepsis, systemic inflammatory response syndrome (SIRS), and MOD and failure, is well described. 5,6 Interleukin 6 (IL6) is an acute-phase protein with predominantly proinflammatory properties. It is produced by a variety of cells, including immune-mediated cells, endothelial cells and mesenchymal cells, upon stimulation by pathogen-associated molecular patterns and damage-associated molecular patterns, 7 as well as by the application of extracorporeal circulation via the contact of blood with foreign material.…”

Section: Introductionmentioning

confidence: 99%

“…8 Clinically, its role is best described in the setting of sepsis, myocardial infarction, rheumatological diseases and metabolic syndrome. 6,9,10 Interleukin 8 (IL8) is an inflammatory mediator, also known as neutrophil chemotactic factor, which can be secreted by any cell with toll-like receptors, such as macrophages and endothelial cells. IL8 is a major response factor following NfκB stimulation, 11 and its serum level also increases during extracorporeal circulation.…”

Section: Introductionmentioning

confidence: 99%

The impact of interleukin serum levels on the prognosis of patients undergoing venoarterial extracorporeal membrane oxygenation

Schopka

Philipp

Müller³

et al. 2020

Artificial Organs

View full text Add to dashboard Cite

show abstract

Role of interleukin-6 to differentiate sepsis from non-infectious systemic inflammatory response syndrome

Cited by 106 publications

References 41 publications

Predicting mortality in patients with sepsis in the emergency department by using combinations of biomarkers and clinical scoring systems: a systematic review.

Predicting mortality in patients with sepsis in the emergency department by using combinations of biomarkers and clinical scoring systems: a systematic review.

Predicting and managing sepsis in burn patients: current perspectives

The impact of interleukin serum levels on the prognosis of patients undergoing venoarterial extracorporeal membrane oxygenation

Contact Info

Product

Resources

About