Role of Interleukin 8 in Uterine Natural Killer Cell Regulation of Extravillous Trophoblast Cell Invasion

Oliveira, Leandro De; Lash, Gendie E.; Murray-Dunning, C.; Bulmer, Judith N.; Innes, Barbara A.; Searle, Roger F.; Sass, Nelson; Robson, Stephen C.

doi:10.1016/j.placenta.2010.04.012

Cited by 85 publications

(72 citation statements)

References 38 publications

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“…In the early pregnant human decidua, uNK cells are a major producer of CXCL8 (Saito et al, 1994;De Oliveira et al, 2010). There are also reports describing expression of CXCL8 in the pregnant decidua and it is likely to be involved in leucocyte trafficking to the spiral arteries during the first trimester of pregnancy (Hornung et al, 1997;Jones et al, 2004).…”

Section: Cxcl8/il-8mentioning

confidence: 99%

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Decidual cytokines and pregnancy complications: focus on spontaneous miscarriage

Lash

Ernerudh

2015

Journal of Reproductive Immunology

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The establishment of pregnancy requires the co-ordinated implantation of the embryo into the receptive decidua, placentation, trophoblast invasion of the maternal decidua and myometrium in addition to remodelling of the uterine spiral arteries. Failure of any of these steps can lead to a range of pregnancy complications, including miscarriage, pre-eclampsia, fetal growth restriction, placenta accreta and pre-term birth. Cytokines are small multifunctional proteins often derived from leucocytes and have primarily been described through their immunomodulatory actions. The maternal-fetal interface is considered to be immunosuppressed to allow development of the semi-allogeneic placental fetal unit. However, cytokine profiles of the decidua and different decidual cell types suggest that the in vivo situation might be more complex. Data suggest that decidual-derived cytokines not only play roles in immunosuppression, but also in other aspects of the establishment of pregnancy, including the regulation of trophoblast invasion and spiral artery remodelling. This review focuses on the potential role of decidua-derived cytokines in the aetiology of unexplained spontaneous miscarriage. (C) 2015 Elsevier Ireland Ltd. All rights reserved

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Section: Cxcl8/il-8mentioning

confidence: 99%

“…CXCL8 has been shown to stimulate trophoblast invasion in in vitro models and contribute to the uNK cell stimulation of trophoblast invasion (Hanna et al, 2006;De Oliveira et al, 2010).…”

Section: Cxcl8/il-8mentioning

confidence: 99%

Decidual cytokines and pregnancy complications: focus on spontaneous miscarriage

Lash

Ernerudh

2015

Journal of Reproductive Immunology

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“…CD8 þ T lymphocytes are a minor leukocyte population in early pregnancy decidua (Williams et al 2009). CD8 þ T lymphocyte supernatants also stimulate EVT invasion in an explant Matrigel transwell invasion assay but only when stimulated with PHA-P (Scaife et al 2006;De Oliveira et al 2010).…”

Section: Cross-talk At the Feto -Maternal Interfacementioning

confidence: 99%

Molecular Cross-Talk at the Feto–Maternal Interface

Lash

2015

Cold Spring Harb Perspect Med

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Molecular cross-talk at the feto-maternal interface occurs between many different cell types, including uterine leukocytes, extravillous trophoblast cells, and uterine spiral arteries, is essential for the establishment and maintenance of pregnancy. This review concentrates on human pregnancy and examines three main areas in which cross-talk occurs; immune tolerance, regulation of extravillous trophoblast invasion, and remodeling of the uterine spiral arteries.

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“…For instance, they have been shown to be closely associated with remodeling vessels (Smith et al, 2009;Hazan et al, 2010), to promote trophoblast invasion (Hanna et al, 2006;De Oliveira et al, 2010;Fraser et al, 2012) and to stimulate vascular remodeling by the production of angiogenic factors (Hanna et al, 2006;Lash et al, 2006;Kalkunte et al, 2009). The interaction of activating NK cell receptors with MHC I molecules on trophoblast cells seems to promote both chemotactic and angiogenic factors (Hanna et al, 2006), suggesting that a moderate level of activation is necessary for proper trophoblast invasion and spiral artery remodeling.…”

Section: Decidual Nk Cellsmentioning

confidence: 99%

Immune regulation at the fetal‐maternal interface with focus on decidual macrophages

Svensson‐Arvelund¹

2015

Linköping University Medical Dissertations

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A successful pregnancy requires that the maternal immune system adapts to tolerate the semi-allogeneic fetal-placental unit. This adaptation mainly occurs locally, i.e. at the fetal-maternal interface, where fetal-derived tissues come into close contact with maternal cells in the uterine endometrium (called decidua during pregnancy). decidual macrophages preferentially secreted the monocyte-and Treg cell-associated chemokines CCL2 and CCL18, while Th1-, Th2-and Th17-related chemokines were produced at low levels. These results suggest that decidual macrophages contribute to create the unique decidual cell composition and a tolerogenic immune environment that is compatible with fetal development. Further, by comparing decidual macrophages with different in vitro macrophage subsets, we showed that M-CSF and

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Role of Interleukin 8 in Uterine Natural Killer Cell Regulation of Extravillous Trophoblast Cell Invasion

Cited by 85 publications

References 38 publications

Decidual cytokines and pregnancy complications: focus on spontaneous miscarriage

Decidual cytokines and pregnancy complications: focus on spontaneous miscarriage

Molecular Cross-Talk at the Feto–Maternal Interface

Immune regulation at the fetal‐maternal interface with focus on decidual macrophages

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