Role of intrafollicular regulators and FSH in growth and development of large antral follicles in sheep

Cahill, L. P.; Driancourt, Marc Antoine; Chamley, W. A.; Findlay, J. K.

doi:10.1530/jrf.0.0750599

Cited by 42 publications

(22 citation statements)

References 23 publications

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“…It has been suggested that FSH (Findlay & Cumming, 1977;Baird, 1983;Cahill, Driancourt, Chamley & Findlay, 1985) as well as intra-or inter-ovarian regulatory agents may control growth rates of small antral follicles (<2mm). Furthermore, proteins secreted by large antral follicles are likely candidates for the control of selection of ovulating follicles through atresia in ewes and pigs (Ledwitz-Rigby, 1985).…”

Section: Discussionmentioning

confidence: 99%

Ovarian follicular development during early pregnancy in cattle

Guilbault¹,

Dufour²,

Thatcher³

et al. 1986

Reproduction

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Summary. On the day of oestrus (Day 0), 23 cows were assigned randomly to 4 groups in a 2 \ m=x\2 factorial experiment. Main percentage of non-atretic follicles (<4 pycnotic bodies) was lower (P<0\m=.\002) in pregnant than non-pregnant groups in the smallest class of antral follicles (0\ m=. \ 16\ p=n-\ 0\ m=. \ 28mm) but was higher (P<0\m=.\03) in larger classes (0\ m=. \ 68\ p=n-\ 3\ m=. \ 67mm) for pregnant groups. Percentages of atretic follicles were 3\m=.\7and 4\m=.\9(P>0\m=.\1)for follicles of 0\m=.\16\p=n-\0\m=.\67 mm, 91\m=.\1and 78\m=.\9for follicles of 0\m=.\68\p=n-\3\m=.\67mm (P<0\m=.\04) and 5\m=.\1and 16\m=.\1 (P<0\m=.\05) for follicles of 3\m=.\67\p=n-\78\m=.\56mm in pregnant and non-pregnant groups respectively. The percentage of atretic follicles classified as late atretic was higher in pregnant than in non-pregnant groups for follicles of 0\m=.\68\p=n-\1\m=.\57mm (P < 0\m=.\06) and 3\m=.\68\p=n-\8\m=.\56mm (P < 0\m=.\05). The results suggest that, as early as Day 17, the presence of a conceptus favours a more rapid turnover of follicles from class 1 (0\ m=. \ 16\ p=n-\ 0\ m=. \ 28mm) to classes 3 and 4 (0\ m=. \ 68\ p=n-\ 3\ m=. \ 67mm) but limits further growth by increasing atresia.

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Section: Discussionmentioning

confidence: 99%

Ovarian follicular development during early pregnancy in cattle

Guilbault¹,

Dufour²,

Thatcher³

et al. 1986

Reproduction

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“…Di Zerega identified a protein with a molecular weight between 14 000 and 18 000 kDa secreted by the dominant follicle in humans which suppressed the follicular response to gonadotrophins (di Zerega, 1982). Cahill et al demonstrated that ovine follicular fluid inhibited the development of follicles >2 mm in diameter in the ovary and reduced the mitotic index of the granulosa cells of follicles <2 mm (Cahill et al, 1985). Later, substances with molecular weights of 18 000 and <10 000 kDa were identified in ovine follicular fluid that inhibited the mitotic activity of murine embryonic lung fibroblasts (Carson et al, 1988).…”

Section: 'Inductive Signalling' and Follicular Dominancementioning

confidence: 99%

The role of intra-ovarian interactions in the regulation of follicle dominance

Baker¹,

Spears²

1999

Human Reproduction Update

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The processes that precisely control the selection of ovulatory follicles from a growing cohort are poorly understood. This reduction in follicle number occurs through several phases of selection, consequently we limit the use of the term 'selection' to the first major reduction of growing follicles, at the pre-to early antral stage. The final process of selection, achieving the appropriate ovulatory number, is referred to as 'dominance'. We discuss possible mechanisms that could bring about these reductions and highlight intra-ovarian involvement, particularly via follicle-follicle interactions. Analogies are drawn between local ovarian events and processes commonly reported in the determination of cell fate in developmental biology. Two facets of intra-follicular interactions are proposed: initially that follicle-follicle interactions mediate early selection processes at the preantral stage, and later that during antral development dominant follicles directly affect the fate of the subordinate cohort members.

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“…Pituitary gonadotrophins (FSH and LH) are essential to allow development of follicles larger than 2 mm (Dufour et al, 1979;McNeilly et al, 1986), but the terminal development of large follicles is most probably regulated by local intraovarian factors rather than systemic hormonal concentrations (Cahill et al, 1985;Dorrington et al, 1987;Driancourt & Fry, 1988;Fry et al, 1988). Numerous compounds have been identified in the follicu¬ lar fluid and reported to stimulate (TGF: Ying et al, 1986;IGF^Dorrington et al, 1987) or inhibit (EGF: Shaw et al, 1985;inhibin: Ying et al, 1986;FRP: diZerega et al, 1987) follicular differen¬ tiation.…”

Section: Introductionmentioning

confidence: 99%

Follicular dynamics and dominance in Booroola x Finnish Landrace and Booroola x Suffolk ewes heterozygous for the F gene

Castonguay¹,

Dufour²,

Minvielle³

et al. 1990

Reproduction

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Summary. To Group 3, the proportion of marked follicles that ovulated was higher for S ewes than in those of the prolific genotypes. The number of follicles not marked at Day 0 but ovulating (compared to the total number of ovulations) was higher in BFL, BS and FL (8/11, 9/13 and 9/13) than S (3/10) ewes. In Exp. 2, prolific (BFL + BS) and non-prolific (S) ewes were compared following destruction of follicles \m=ge\3mmwith the F1 left intact (Treatment 1) or destroyed (Treatment 2), 12 days after sponge insertion. At 4 days after treatment (at sponge removal), the numbers of 3\p=n-\4mm follicles were not different between the 2 treatments and a very high proportion of the F1 follicles left intact at Day 0 had regressed at Day 4 in both genotypes. From these results, it can be concluded that the higher ovulation rate in Booroola-crossed ewes is not associated with a higher number of recruitable follicles but involves late follicular-phase recruitment and selection combined with smaller preovulatory follicle diameters. Dominance by the largest follicle is not present in ewes of prolific or non-prolific genotypes. In contrast, it is likely that small sized follicles exert a negative effect on growth of large follicles.

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Role of intrafollicular regulators and FSH in growth and development of large antral follicles in sheep

Cited by 42 publications

References 23 publications

Ovarian follicular development during early pregnancy in cattle

Ovarian follicular development during early pregnancy in cattle

The role of intra-ovarian interactions in the regulation of follicle dominance

Follicular dynamics and dominance in Booroola x Finnish Landrace and Booroola x Suffolk ewes heterozygous for the F gene

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