Role of Intravenous Tranexamic Acid before Elective Caesarean Section in Preventing Postpartum Hemorrhage

Abstract

Background: Post-partum hemorrhage is one of the most common obstetric emergencies. However, Tranexamic acid (TXA) is a medication used to treat or prevent excessive blood loss due to trauma, surgery and medical conditions including hemophilia and heavy menstrual bleeding. Objective: To determine the role of intravenous tranexamic acid before elective caesarean section in preventing postpartum hemorrhage at tertiary care hospital. Study Design: Randomized control trial. Settings: Obstetrics & Gynecology Department, Allied Hospital Faisalabad Pakistan. Duration: 6 months from March 02, 2019 to August 01, 2019. Methodology: After taking demographic information and informed consent, all the patients were randomly divided into two groups by using random number table. Group A patients received tranexamic acid (1gm/10ml TA diluted with 20ml of 5% glucose) and group B patients not received tranexamic acid (placebo). Blood loss was noted by measuring the total blood collected in kidney tray of 10" size during delivery of placenta till completion of caesarean section. All this information was recorded through study proforma. Data was entered and analyzed on SPSS version 21. Results: In our study the mean age of the patients was 29.90±6.06 years. The mean blood loss value of the patients was 387.27±89.56 ml. Statistically highly significant difference was found between the study groups with blood loss of the patients i.e. p-value=0.000. Conclusion:It has been proved in our study that the tranexamic acid is useful and effective drug to control the mean blood loss before delivery in females undergoing elective caesarean section as compared to placebo group.