Role of IOS in evaluation of patients with interstitial lung diseases

Naglaa, B.A.; Kamal, Eman

doi:10.1016/j.ejcdt.2016.05.002

Cited by 6 publications

(4 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Airway diseases, such as bronchitis, emphysema, bronchiectasis, COPD, and interstitial lung disease, can also show abnormal IOS values. 32 33 34 Therefore, it is always necessary to discriminate among these diseases that may affect IOS values. Thirdly, although there are many reference values associated with adult IOS, 13 35 36 37 38 there are no clear reference values for adult asthma.…”

Section: Discussionmentioning

confidence: 99%

Application of Impulse Oscillometry in Adult Asthmatic Patients With Preserved Lung Function

Kim

Park

Son

et al. 2020

Allergy Asthma Immunol Res

View full text Add to dashboard Cite

Purpose It is difficult to assess airway obstruction using spirometry in adult asthmatic patients with preserved lung function. Impulse oscillometry (IOS) can detect not only airway resistance but also reactance. Therefore, IOS may be useful in assessing pulmonary function in such patients. We investigated the applicability of IOS for asthma patients with preserved lung function. Methods Between 2015 and 2018, 1,248 adult asthmatic patients suspected of having asthma who visited the Allergy and Asthma Center of Severance Hospital underwent both spirometry and IOS. Consequently, 784 patients had asthma, 111 had chronic obstructive lung disease (COPD) or asthma-COPD overlap, and 7 had parenchymal lung disease. The remaining 346 patients had chronic cough without underlying lung or airway disease. Among the 784 asthmatic patients, 191 with decreased lung function (predicted forced expiratory volume in 1 second [FEV1] < 80%) were excluded. Propensity score matching was performed to adjust baseline characteristics between 346 non-asthmatic and 593 asthmatic patients with preserved lung function. Subsequently, we compared the spirometry and IOS parameters between the 329 asthmatic and 329 non-asthmatic patients. Results Multiple logistic regression analysis showed that the area of reactance (AX) was associated with asthma with preserved lung function. In receiver operating characteristic (ROC) curve analysis, the area under the curve (AUC) of AX (AUC = 0.6823) for asthma was not significantly different from that of FEV1 (AUC = 0.6758). However, the AUC of a combination of AX and FEV1 (AUC = 0.7437) for asthma was significantly higher than that of FEV1 alone. The cutoff value of AX was 0.51 kPa/L in univariate ROC analysis. Conclusions AX is associated with adult asthma with preserved lung function. Performing spirometry together with IOS is more beneficial than performing spirometry alone for diagnosing asthma in adult patients with preserved lung function.

show abstract

Section: Discussionmentioning

confidence: 99%

Application of Impulse Oscillometry in Adult Asthmatic Patients With Preserved Lung Function

Kim

Park

Son

et al. 2020

Allergy Asthma Immunol Res

View full text Add to dashboard Cite

show abstract

“…In restrictive lung diseases, there is typically no effect on the Resistance but a significant increase in A X . [30][31][32] Hence, oscillometry could help discriminate between various types of lung disease and add to the quality of diagnosis.…”

Section: Background Of Oscillometrymentioning

confidence: 99%

“…Both obstructive and fibrotic lung disease downwardly depress the reactance curve signaling an increase in respiratory system elastance. [30][31][32]53 While a stiffening of the respiratory system by fibrotic lung disease is easy to comprehend, it is less intuitive why this is so with obstructive lung disease. However, this is what sets oscillometry apart from other forms of lung function measurement.…”

Section: Reasons Why Ventilatory Inhomogeneity Stiffens the Lungmentioning

confidence: 99%

Applications of oscillometry in clinical research and practice

Lundblad

Siddiqui

Bossé

et al. 2019

Canadian Journal of Respiratory, Critical Care, and Sleep Medic

View full text Add to dashboard Cite

Oscillometry is gaining in clinical use and while there is an increased interest in the technique, there is paucity in the understanding of its possibilities and limitations. Oscillometry has seen extensive use in research over several decades, but only recently is the technique being adopted in clinical practice; hence, there is a need to educate the novel users. The goal of the mini symposium arranged in San Diego in 2018 was to discuss the principles of oscillometry, showcase some of the recent ongoing research using this technique and to demonstrate how oscillometry may be used in clinical practice. It was concluded that oscillometry has several advantages over spirometry, most notably, with novel data being shown, its sensitivity allowing early detection of small airways disease not possible with spirometry and it can be used in subjects who have difficulties performing forced maneuvers such as preschool children, the elderly and subjects with handicaps. The site of respiratory pathology can be reflected by the various parameters generated by oscillometry and thus help with both disease diagnosis and localization. While the interpretation of oscillometry parameters and translating them into meaningful pathological correlates is still evolving, it is likely that oscillometry will soon be at the forefront of both pulmonary clinical practice and research. R ESUM EL'oscillom etrie est de plus en plus utilis ee en contexte clinique, mais malgr e l'int erêt accru pour cette technique, la compr ehension de ses possibilit es et de ses limites est encore insuffisante. Pendant plusieurs d ecennies, l'oscillom etrie a largement et e utilis ee dans la recherche, mais l'adoption de cette technique dans la pratique clinique est encore r ecente, de sorte qu'il est n ecessaire de former les nouveaux utilisateurs. Le but de ce mini symposium qui s'est tenu a San Diego en 2018 etait de discuter des principes de l'oscillom etrie, de pr esenter les plus r ecentes etudes utilisant cette technique et de d emontrer comment elle peutêtre utilis ee dans la pratique clinique. Il a et e d etermin e que l'oscillom etrie pr esentait plusieurs avantages par rapport a la spirom etrie notamment, comme le d emontrent de nouvelles donn ees, sa sensibilit e qui permet la d etection pr ecoce de la maladie des petites voies a eriennes, ce que la spirom etrie ne peut pas faire, ainsi que le fait qu'elle puisseêtre utilis ee aupr es de sujets qui eprouvent de la difficult e a effectuer des manoeuvres forc ees comme les enfants d'âge pr escolaire, les personnesâg ees et les personnes atteintes d'un handicap. L'emplacement de la pathologie respiratoire peut se refl eter dans les divers param etres produits par la spirom etrie, ce qui peut contribuer a diagnostiquer la maladie et a la localiser. Bien que l'interpr etation des param etres de l'oscillom etrie et leur traduction dans des corr elats pathologiques significatifs continue d' evoluer, l'oscillom etrie sera vraisemblablement a l'avant-plan de la pratique clinique et de la recherche pulmonair...

show abstract

“…Yet, the technique has the potential to measure the physiological consequences both in the clinical and preclinical context because of its ability to probe the lung periphery. It has been suggested that the reactance is particularly sensitive to changes in interstitial lung diseases whereas the resistance is less affected (41,142,143,177). In mice models of pulmonary fibrosis (Table 1), oscillometry is a technique commonly used to demonstrate a disease phenotype or a treatment effect.…”

Section: Pulmonary Fibrosismentioning

confidence: 99%

Oscillometry of the respiratory system: a translational opportunity not to be missed

Lundblad

Robichaud²

2021

American Journal of Physiology-Lung Cellular and Molecular Phys

View full text Add to dashboard Cite

Airway oscillometry has become the de facto standard for quality assessment of lung physiology in laboratory animals and has demonstrated its usefulness in understanding diseases of small airways. Nowadays, it is seeing extensive use in daily clinical practice and research, however, a question that remains unanswered is how well physiological findings in animals and humans correlate? Methodological and device differences are obvious between animal and human studies. However, all devices deliver an oscillated airflow test signal and output respiratory impedance. In addition, despite analysis differences, there are ways to interpret animal and human oscillometry data to allow suitable comparisons. The potential with oscillometry is its ability to reveal universal features of the respiratory system across species, making translational extrapolation likely to be predictive. This means that oscillometry can thus help determine if an animal model displays the same physiological characteristics as the human disease. Perhaps more importantly, it can also be useful to determine whether an intervention is effective as well as to understand if it affects the desired region of the respiratory system e.g., the periphery of the lung. Finally, findings in humans can also inform preclinical scientists and give indications as to what type of physiological changes should be observed in animal models to make them relevant as models of human disease. The present article will attempt to demonstrate the potential of oscillometry in respiratory research, an area where the development of novel therapies is plagued with a failure rate higher than in other disease areas.

show abstract

Role of IOS in evaluation of patients with interstitial lung diseases

Cited by 6 publications

References 18 publications

Application of Impulse Oscillometry in Adult Asthmatic Patients With Preserved Lung Function

Application of Impulse Oscillometry in Adult Asthmatic Patients With Preserved Lung Function

Applications of oscillometry in clinical research and practice

Oscillometry of the respiratory system: a translational opportunity not to be missed

Contact Info

Product

Resources

About