Role of Irisin in Myocardial Infarction, Heart Failure, and Cardiac Hypertrophy

Ho, Ming-Yun; Wang, Chao-Yung

doi:10.3390/cells10082103

Cited by 69 publications

(37 citation statements)

References 88 publications

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“…Myocardial dysfunction is an important feature of cardiomyopathy caused by many reasons. Myocardial dysfunction eventually leads to heart failure (HF) [ 1 ]. Genetic factors are also a key factor in the occurrence of heart failure.…”

Section: Introductionmentioning

confidence: 99%

Effect of Ghrelin Intervention on the Ras/ERK Pathway in the Regulation of Heart Failure by PTEN

Zhao

Sun

et al. 2022

Computational and Mathematical Methods in Medicine

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Objective. To study the possible mechanism of ghrelin in heart failure and how it works. Method. In vitro results demonstrated that ghrelin alleviates cardiac function and reduces myocardial fibrosis in rats with heart failure. Moreover, ghrelin intervention increased PTEN expression level and reduced ERK, c-jun, and c-Fos expression level; in vivo experiments demonstrated that ghrelin intervention reduces mast memory expression and increases cardiomyocyte surface area, PTEN expression level, ERK, c-jun, c-Fos expression level, and cell surface area, while ERK blockade suppresses mast gene expression and reduces cell surface area. Results. In vitro experimental results prove that we have successfully constructed a rat model related to heart failure, and ghrelin can alleviate the heart function of heart failure rats and reduce myocardial fibrosis. In addition, ghrelin is closely related to the decrease of the expression levels of ERK, c-jun, and c-Fos, but it can also increase the expression of PTEN in the rat model; in vivo experiments proved that we successfully constructed an in vitro cardiac hypertrophy model, and the intervention of ghrelin would reduce the expression of hypertrophic memory and increase the surface area of cardiomyocytes, increase the expression level of PTEN, and reduce the expression levels of ERK, c-jun, and c-Fos, while the blockade of PTEN will increase the expression of hypertrophy genes and increase the cell surface area, while the blockade of ERK will increase the expression of hypertrophic genes, which in turn will make the cell surface area reducing. Conclusion. Ghrelin inhibits the phosphorylation and nuclear entry of ERK by activating PTEN, thereby controlling the transcription of hypertrophic genes, improving myocardial hypertrophy, and enhancing cardiac function.

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Section: Introductionmentioning

confidence: 99%

Effect of Ghrelin Intervention on the Ras/ERK Pathway in the Regulation of Heart Failure by PTEN

Zhao

Sun

et al. 2022

Computational and Mathematical Methods in Medicine

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“…A selective patient population, such as those with cachexia, T2DM, or chronic kidney disease [ 36 , 37 , 38 ], also presents challenges in this regard. On this occasion, irisin was a promising indicator of CV events [ 39 , 40 ].…”

Section: Discussionmentioning

confidence: 99%

Discriminative Value of Serum Irisin in Prediction of Heart Failure with Different Phenotypes among Patients with Type 2 Diabetes Mellitus

Berezin

Lichtenauer

Boxhammer

et al. 2022

Cells

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Recent studies have shown that circulating levels of irisin are prognostic factors in heart failure (HF), but no data are available on the predictive role of irisin in patients with type 2 diabetes mellitus (T2DM) and different phenotypes of HF. The aim of the study was to investigate whether serum levels of irisin predict HF in T2DM patients. We prospectively included 183 participants with T2DM aged 41 to 62 years (30 non-HF patients and 153 HF patients) and 25 healthy volunteers in the study and evaluated clinical data, hemodynamics and biomarkers (N-terminal pro-brain natriuretic peptide (NT-proBNP) and irisin). Serum levels of irisin < 8.30 ng/mL were found to be a better indicator of HF with reduced ejection fraction (HFrEF) than irisin ≥ 8.30 ng/mL, but the predictive cut-off point for NT-proBNP remained the same as for HF with mildly reduced ejection fraction (HFmrEF). Serum levels of irisin < 10.4 ng/mL significantly improved the predictive ability of NT-proBNP for HF with preserved ejection fraction (HFpEF). In conclusion, we found that decreased serum levels of irisin significantly predicted HFpEF, rather than HFmrEF and HFrEF, in T2DM patients. This finding may open a new approach to HF risk stratification in T2DM patients.

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“…M. Y. Ho and C. Y. Wang (2021) identified the mechanisms of action of irisin through the main pathways PI3K / Akt / eNOS, AMPK [6]. Authors G. Zhu et al (2016) found that irisin not only directly regulates the number of endothelial progenitor cells, but can also act indirectly by regulating glucose and triglyceride metabolism [23].…”

Section: Discussionmentioning

confidence: 99%

Features of energy and adipokine metabolism in patients with acute myocardial infarction and type 2 diabetes after percutaneous coronary intervention

Koteliukh¹

2021

Rep. of Vinnytsia Nation. Med. Univ.

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Annotation. The study of energy and adipokine metabolism indicators for the development and course of acute myocardial infarction (AMI) with comorbidity remains relevant. The aim of the study was to determine the content of energy and adipokine metabolism in patients with myocardial infarction and ST-segment elevation depending on the presence and absence of type 2 diabetes mellitus (DM) after percutaneous coronary intervention (PCI). The study involved examination of 60 patients with AMI (Group 1) and 74 patients with AMI and type 2 diabetes (Group 2). Each group was divided into 2 subgroups according to coronary artery (CA) stenting. The control group included 20 healthy individuals. Adropin, irisin, fatty acid binding protein 4 (FABP 4), C1q / TNF-associated protein 3 (CTRP 3) were determined by enzyme-linked immunosorbent assay. All patients underwent coronary angiography. Statistical processing of the results of the study was carried out using the software package “IBM SPPS Statistics 27.0”. There was a decrease in the content of adropin, irisin and CTRP 3 and an increase in the concentration of FABP 4 on day 1 in Groups 1 and 2 compared with the control group (p˂0.05). In Groups 1 and 2 on day 14 there was an increase in the concentration of adropin by 23.87% and 41.43%, irisin by 56.59% and 11.11%, CTRP3 by 11.59% and 20.01% compared to day 1 (p<0.05). The level of FABP 4 in Groups 1 and 2 decreased by 19.69% and 26.61% compared to day 1 (p <0.05). In Group 1, an inverse correlation was found between Syntax Score (SS) and adropin (r= -0.432, p=0.01), irisin (r= -0.478, p<0.01), CTRP 3 (r= - 0.473, p<0.01) and a positive correlation between SS and FABP 4 (r= 0.436, p<0.05). In Group 2, there was an inverse relationship between SS and adropin (r= -0.452, p<0.05), irisin (r= -0.458, p<0.05), CTRP 3 (r= -0.437, p<0.05) and the direct relationship between SS and FABP 4 (FABP 4 (r= 0.418, p<0.05). Thus, the peculiarities of the content of energy and adipokine metabolism indicators in patients with AMI with existing and absent type 2 diabetes before and after primary CA stenting were studied.

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Role of Irisin in Myocardial Infarction, Heart Failure, and Cardiac Hypertrophy

Cited by 69 publications

References 88 publications

Effect of Ghrelin Intervention on the Ras/ERK Pathway in the Regulation of Heart Failure by PTEN

Effect of Ghrelin Intervention on the Ras/ERK Pathway in the Regulation of Heart Failure by PTEN

Discriminative Value of Serum Irisin in Prediction of Heart Failure with Different Phenotypes among Patients with Type 2 Diabetes Mellitus

Features of energy and adipokine metabolism in patients with acute myocardial infarction and type 2 diabetes after percutaneous coronary intervention

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