Role of iron-mediated free-radical generation in asbestos-induced cytotoxicity

Brown, R. C.; Poole, A. B.; Turver, C.J.; Vann, Carolyn N.

doi:10.1016/0887-2333(87)90002-6

Cited by 6 publications

(2 citation statements)

References 23 publications

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“…Crocidolite-induced cell death, as measured by uptake in vital dyes, also can be prevented in a dosagedependent fashion by introduction of SOD, catalase, or dimethylthiourea to rat lung fibroblasts or alveolar macrophages in vitro (9). If fibers are pretreated with desferroxamine, an iron chelator, crocidolite is not as toxic, an observation supporting the concept that iron on the surface of fibers drives the modified Haber-Weiss (Fenton) reaction and results in the production of OH * from H202 and O2 (9)(10)(11).…”

Section: Resultsmentioning

confidence: 65%

Evidence supporting a role for active oxygen species in asbestos-induced toxicity and lung disease.

Mossman

Marsh

1989

Environ Health Perspect

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Asbestos is an important occupational and environmental toxicant that affects several cell types in the respiratory tract. In an effort to understand how asbestos causes cell injury and/or altered proliferation and differentiation of cells, this laboratory has focused on reactive oxygen species as mediators of asbestos-induced biological effects. A compendium of experimental results reported by this laboratory and others supports this hypothesis. For example, scavengers of reactive oxygen metabolites and iron chelators (i.e., desferroxamine) prevent cytotoxicity after addition of asbestos to a variety of cell lines and macrophages in vitro. DNA strand breakage associated with toxicity of crocidolite asbestos in C3H10T 1/2 cells also is ameliorated with use of desferroxamine. All types of asbestos cause lipid peroxidation in mammalian cells and artificial membranes, a phenomenon that can be prevented by removal of catalytic iron. Last, asbestos causes generation of active oxygen species after interaction with leukocytes or by reduction of oxygen on the surface of the fibers.ImagesFIGURE 1.

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Section: Resultsmentioning

confidence: 65%

Evidence supporting a role for active oxygen species in asbestos-induced toxicity and lung disease.

Mossman

Marsh

1989

Environ Health Perspect

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“…Although the formation of the ferruginous body has been viewed in general as a mechanism whereby the reactive surfaces of asbestos are masked, the iron coating these fibers might serve as a catalyst for generation of OH* and O@. Clearly, the inhibition of asbestosinduced generation of OH' and O2 from H202 (24), cytotoxicity (6)(7)(8)(9)(10)(11), lipid peroxidation (15,16), and DNA breakage (16) by desferroxamine indicates that the iron content of asbestos fibers is critical to reactions favoring production of active oxygen species.…”

Section: Relevance To Diseasementioning

confidence: 99%

Evidence Supporting a Role for Active Oxygen Species in Asbestos-Induced Toxicity and Lung Disease

Mossman¹,

Marsh²

1989

Environmental Health Perspectives

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Asbestos is an important occupational and environmental toxicant that affects several cell types in the respiratory tract. In an effort to understand how asbestos causes cell injury and/or altered proliferation and differentiation of cells, this laboratory has focused on reactive oxygen species as mediators of asbestos-induced biological effects. A compendium of experimental results reported by this laboratory and others supports this hypothesis. For example, scavengers of reactive oxygen metabolites and iron chelators (i.e., desferroxamine) prevent cytotoxicity after addition of asbestos to a variety of cell lines and macrophages in vitro. DNA strand breakage associated with toxicity of crocidolite asbestos in C3H1OT½ cells also is ameliorated with use of desferroxamine. All types of asbestos cause lipid peroxidation in mammalian cells and artificial membranes, a phenomenon that can be prevented by removal of catalytic iron. Last, asbestos causes generation of active oxygen species after interaction with leukocytes or by reduction of oxygen on the surface of the fibers.

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Calcium chelatro Quin-2 prevens crocidolite-induced DNA strand breakage in human white blood cells

Faux¹,

Michelangeli²,

Levy³

1994

Mutation Research/Fundamental and Molecular Mechanisms of Mutag

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Role of iron-mediated free-radical generation in asbestos-induced cytotoxicity

Cited by 6 publications

References 23 publications

Evidence supporting a role for active oxygen species in asbestos-induced toxicity and lung disease.

Evidence supporting a role for active oxygen species in asbestos-induced toxicity and lung disease.

Evidence Supporting a Role for Active Oxygen Species in Asbestos-Induced Toxicity and Lung Disease

Calcium chelatro Quin-2 prevens crocidolite-induced DNA strand breakage in human white blood cells

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