Role of ischemia-reperfusion in oxidative stress-mediated injury during kidney transplantation

Ávila, Cristóbal; Líbano, Lucas; Rojas, Ignacio; Rodrigo, Ramón

doi:10.15761/crt.1000260

Cited by 5 publications

(4 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Reperfusion inhibits the cytochrome c oxidase and increases NO levels. These parameters are responsible for protein and lipid peroxidation (which increases MDA levels) along with DNA damage, which further aggravates cell necrosis and apoptosis [ 19 , 20 ]. Because of the redox imbalance, a local and systemic inflammatory process is activated.…”

Section: Resultsmentioning

confidence: 99%

Plants with Therapeutic Potential for Ischemic Acute Kidney Injury: A Systematic Review

Ali

Sampaio

Khan

et al. 2022

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

Acute kidney injury (AKI) is a complex condition which has an intricate pathology mostly involving hemodynamic, inflammatory, and direct toxic effects at the cellular level with high morbidity and mortality ratios. Renal ischemic reperfusion injury (RIRI) is the main factor responsible for AKI, most often observed in different types of shock, kidney transplantation, sepsis, and postoperative procedures. The RIRI-induced AKI is accompanied by increased reactive oxygen species generation together with the activation of various inflammatory pathways. In this context, plant-derived medicines have shown encouraging nephroprotective properties. Evidence provided in this systemic review leads to the conclusion that plant-derived extracts and compounds exhibit nephroprotective action against renal ischemic reperfusion induced-AKI by increasing endogenous antioxidants and decreasing anti-inflammatory cytokines. However, there is no defined biomarker or target which can be used for treating AKI completely. These plant-derived extracts and compounds are only tested in selected transgenic animal models. To develop the results obtained into a therapeutic entity, one should apply them in proper vertebrate multitransgenic animal models prior to further validation in humans.

show abstract

Section: Resultsmentioning

confidence: 99%

Plants with Therapeutic Potential for Ischemic Acute Kidney Injury: A Systematic Review

Ali

Sampaio

Khan

et al. 2022

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

show abstract

“…One final point of interest is that ischaemia/reperfusion during transplantation is known to lead to very high ROS levels in the transplanted tissue [ 76 , 77 , 78 , 79 ]. Given the results shown here, it is tempting to speculate that ischaemia/reperfusion could also result in increased CMV reactivation in the allograft.…”

Section: Discussionmentioning

confidence: 99%

The Human Cytomegalovirus β2.7 Long Non-Coding RNA Prevents Induction of Reactive Oxygen Species to Maintain Viral Gene Silencing during Latency

Perera

2022

IJMS

View full text Add to dashboard Cite

Human cytomegalovirus (HCMV) is a significant source of disease for the immunosuppressed and immunonaive. The treatment of HCMV is made more problematic by viral latency, a lifecycle stage in which the virus reduces its own gene expression and produces no infectious virus. The most highly expressed viral gene during HCMV latency is the viral β2.7 long non-coding RNA. Although we have recently shown that the β2.7 lncRNA lowers levels of reactive oxygen species (ROS) during infection in monocytes, how this impacts latency is unclear. We now show that β2.7 is important for establishing and maintaining HCMV latency by aiding the suppression of viral lytic gene expression and that this is directly related to its ability to quench reactive oxygen species (ROS). Consistent with this, we also find that exogenous inducers of ROS cause reactivation of latent HCMV. These effects can be compensated by treatment with an antioxidant to lower ROS levels. Finally, we show that ROS-mediated reactivation is independent of myeloid differentiation, but instead relies on NF-κB activation. Altogether, these results reveal a novel factor that is central to the complex process that underpins HCMV latency. These findings may be of particular relevance in the transplant setting, in which transplanted tissue/organs are subject to very high ROS levels, and HCMV reactivation poses a significant threat.

show abstract

“…Furthermore, excessive increase of ROS is also because of the decreased activity of a variety of antioxidant molecules such as superoxide dismutase, catalase, and glutathione peroxidase. These events influence the mitochondrial respiratory chain activity and burst ROS, resulting in oxidative damage to the bimolecular, including proteins, lipids, and DNA, ending in apoptosis and cell death [ 16 ]. Apoptosis occurs in response to hypoxic stress, resulting from ischemia and ROS production from reperfusion [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

Fimasartan ameliorates renal ischemia reperfusion injury via modulation of oxidative stress, inflammatory and apoptotic cascades in a rat model

et al. 2022

View full text Add to dashboard Cite

Ischemia-reperfusion injury (IRI) can be defined as changes in the functions and structures of the tissues resulting from the restoration of blood after a period of ischemia. This study aimed to assess the potential protective effect of Fimasartan (angiotensin receptor antagonist) in the bilateral renal IRI in male rats through its potential effect on renal functions, modulation of the inflammatory cascade, oxidative stress, and apoptotic effect. The animals were equally assigned into four groups. The sham (negative control) group was exposed to surgical conditions without induction of IRI. The control group was exposed to ischemia by occluding the renal pedicles by clamps for 30 min, followed by restoration of blood for 2h. The vehicle-treated group received dimethyl sulfoxide (DMSO) by intraperitoneal injection (IP) 30 minutes before clamping. Fimasartan-treated group: rats pretreated with Fimasartan a dose of 3 mg/kg IP; this was half hour before occluding the renal pedicles. Animals were then exposed to 30 min ischemia (clamping the renal pedicles) followed by 2h reperfusion by releasing the clamps. Blood samples were collected to examine the levels of serum urea and creatinine. Renal tissue was used to measure the levels of cytokines (TNFα, IL-6) and total antioxidant capacity (TAC). Immunohistochemistry was used to assess the levels of Bax, caspase 3, and Bcl-2. Histopathological analyses were performed to detect the parenchymal injury. The present study shows that pretreatment with Fimasartan improves kidney function through its effects on oxidative stress, cytokines, and apoptotic markers.

show abstract

Role of ischemia-reperfusion in oxidative stress-mediated injury during kidney transplantation

Cited by 5 publications

References 29 publications

Plants with Therapeutic Potential for Ischemic Acute Kidney Injury: A Systematic Review

Plants with Therapeutic Potential for Ischemic Acute Kidney Injury: A Systematic Review

The Human Cytomegalovirus β2.7 Long Non-Coding RNA Prevents Induction of Reactive Oxygen Species to Maintain Viral Gene Silencing during Latency

Fimasartan ameliorates renal ischemia reperfusion injury via modulation of oxidative stress, inflammatory and apoptotic cascades in a rat model

Contact Info

Product

Resources

About