Role of killer cell immunoglobulin-like receptor gene content and human leukocyte antigen–C group in susceptibility to human T-lymphotropic virus 1–associated myelopathy/tropical spastic paraparesis in Peru

Talledo, Michael; López, Gladys Galvis; Huyghe, Jeroen R.; Verdonck, Kristien; González, Elsa; Clark, Daniel; Senitzer, David; Vanham, Guido; Gotuzzo, Eduardo; Camp, Guy Van; Laer, Lut Van

doi:10.1016/j.humimm.2010.05.011

Cited by 4 publications

(3 citation statements)

References 33 publications

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“…However in these two cohorts, we found no association of KIR3DS1, either alone or together with HLABw4-80I, with disease outcome. This is in agreement with the study of Talledo et al which found no difference in the presence of the KIR3DS1 gene in HAM/TSP patients relative to ACs in a cohort of HTLV-1 patients in Peru [33]. Our initial finding in the Jamacian cohort may be a reflection of the small size of this group or a reflection of bias in the selection of the AS group which were identified from a nationwide serosurvey rather than disease registries and clinics.…”

Section: Discussionsupporting

confidence: 92%

In contrast to HIV, KIR3DS1 does not influence outcome in HTLV-1 retroviral infection

et al. 2012

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While most carriers of human T-cell leukemia virus type 1 (HTLV-1) remain asymptomatic throughout their lifetime, infection is associated with the development of adult T cell leukemia (ATL) and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). The exact parameters that determine these outcomes are unknown but are believed to include host genetic factors that control the immune response to infection. Host response to fellow retroviridae member HIV is influenced by the expression of members of the Killer Immunoglobulin Receptor (KIR) family including KIR3DS1. In this study we examined the association of KIR3DS1 with the outcome of HTLV-1 infection in three geographically distinct cohorts (Jamaican, Japanese and Brazilian). Despite increased prevalence of KIR3DS1 in the HAM/TSP patients of the Jamaican cohort, we found no evidence for a role of KIR3DS1 in influencing control of proviral load or disease outcome. This suggests that unlike HIV, KIR3DS1-mediated regulation of HTLV-1 infection does not occur, or is ineffective.

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Section: Discussionsupporting

confidence: 92%

In contrast to HIV, KIR3DS1 does not influence outcome in HTLV-1 retroviral infection

et al. 2012

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“…The initial approach to infer the influence of KIR on HTLV-1 infection was possible action of specific KIR genes and HLA-Cw groups in the development of HAM. Although there was a trend of association of genes with neuropathology and proviral load, in the final step, no significant associations were found between KIR genes and HLA-Cw groups in people with a clinical diagnosis of HAM [37].…”

Section: Htlv-1 Infected Subjects’ Immunogenetic Profilementioning

confidence: 99%

Influence of Immunogenetic Biomarkers in the Clinical Outcome of HTLV-1 Infected Persons

Vallinoto

Queiroz

et al. 2019

Viruses

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Human T-lymphotropic virus 1, a member of the Retroviridae family, causes a neglected, silent, persistent infection affecting circa 5 to 10 million people around the world, with biology, immune pathology, clinical diseases, epidemiology, and laboratory issues still unsolved. Most of the infected subjects are asymptomatic, but severe clinical disorders appear as a neurodegenerative disease (HTLV-1 associated myelopathy—HAM) or a lymphoprolipherative disorder (Adult T Leukemia/Lymphoma—ATLL) and in other target organs of the human body. HTLV-1 infections are frequently asymptomatic, but there is a large spectrum of diseases that have been described along the years. The mechanisms by which the virus interacts with the host, the different modes of response of the host to the infection, and the immunogenic characteristics of the host are some of the interesting and unanswered questions that may direct the outcome of the disease. The most relevant published results dealing with the genetic variations of the host, the immune response to HTLV-1 infection, and the outcome of the infection are presented herein, including Human Leucocyte Antigen (HLA), Killer Immunoglobulin-like Receptors (KIR), interleukin 6, 10, 28, Fas and Fas ligand, IFN-gamma, TNF-A, and Mannose-binding lectin. In summary, there are still several unmet research needs in the field of useful biomarkers on HTLV-1 pathogenesis.

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“…In this context, specific haplotypes of the human leukocyte antigen (HLA) and killer immunoglobulin-like receptors (KIR) genes may be associated with an abnormal immune response that could contribute to or slow down the progression of ATL, as already observed in HAM/TSP. 25 There is marked evidence that MHC class I genotyping influences the course of infection with HTLV-1. 26 For example, in a population from southern Japan, class I HLA-A2 and HLA-Cw8 alleles were considered as protective factors for the development of HAM/TSP, and were associated with a lower proviral load in asymptomatic carriers.…”

mentioning

confidence: 99%

Adult T-cell leukemia/lymphoma

Oliveira

Farre

Bittencourt

2016

Rev. Assoc. Med. Bras.

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Role of killer cell immunoglobulin-like receptor gene content and human leukocyte antigen–C group in susceptibility to human T-lymphotropic virus 1–associated myelopathy/tropical spastic paraparesis in Peru

Cited by 4 publications

References 33 publications

In contrast to HIV, KIR3DS1 does not influence outcome in HTLV-1 retroviral infection

In contrast to HIV, KIR3DS1 does not influence outcome in HTLV-1 retroviral infection

Influence of Immunogenetic Biomarkers in the Clinical Outcome of HTLV-1 Infected Persons

Adult T-cell leukemia/lymphoma

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