“…Clinical research methodology has evolved rapidly in some parts of the world, yet elsewhere there is neither the experience, nor the necessary infrastructure, (Lai et al, 1995), (Cox and Zoellner, 2009) Splints or other devices (including postsurgery) (Patil and Parkhedkar, 2009), (Nayak et al, 2009), (Le et al, 1996), (Huang et al, 2008) Microwave diathermy (Gupta et al, 1980), (Gupta et al, 1992) Oral submucous fibrosis, medical management AR Kerr et al (Borle and Borle, 1991), (Kumar et al, 1991) Vitamin A and vitamin B complex (Khanna and Andrade, 1995) Vitamin B complex (Lai et al, 1995) Vitamin B complex (with iodine injection) (Gupta et al, 1992) Vitamins A, B complex, C, D and E plus minerals iron, copper, zinc, magnesium and others (Maher et al, 1997) Ferrous fumarate (Borle and Borle, 1991) Zinc (Kumar et al, 1991) Antioxidants (b-carotene, vitamins A, C and E, zinc, copper, manganese and selenium) (Jirge et al, 2008) Glucosidorum tripterygii totorum, vitamins A and E, nicotinic acid (Liu et al, 1999) Tea pigment, vitamins A, B complex, D and E (Li and Tang, 1998) Lycopene (Kumar et al, 2007) Placental extract (Kakar et al, 1985), (Gupta and Sharma, 1988), …”