Role of l-Arginine in Oligohydramnios

Soni, Anita; Seeru, Garg; Patel, Khushboo; Patel, Zarna

doi:10.1007/s13224-016-0853-7

Cited by 8 publications

(18 citation statements)

References 9 publications

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“…The fetus is surrounded by the amniotic fluid which serves as a cushion. 1,2 The amniotic fluid is a vital liquid which contains nutrients and growth factors that are required for normal fetal growth and allows the assessment of fetal maturity. 3 About 3-5% of pregnancies are affected by oligohydramnios, a condition with decreased amount of amniotic fluid, which results in placental insufficiency, impaired lung development in fetus and fetal growth restriction (FGR).…”

Section: Introductionmentioning

confidence: 99%

“…3 About 3-5% of pregnancies are affected by oligohydramnios, a condition with decreased amount of amniotic fluid, which results in placental insufficiency, impaired lung development in fetus and fetal growth restriction (FGR). 1,4 Long-term complications of oligohydramnios include cord compression and increased chances of operative deliveries. 1,4 The amniotic fluid volume is calculated with the fourquadrant technique done by ultrasound.…”

Section: Introductionmentioning

confidence: 99%

“…1,4 Long-term complications of oligohydramnios include cord compression and increased chances of operative deliveries. 1,4 The amniotic fluid volume is calculated with the fourquadrant technique done by ultrasound. 1,4 It is the sum of the maximum vertical fluid pockets (measured in cm) in each of the four quadrants.…”

Section: Introductionmentioning

confidence: 99%

“…1,4 The amniotic fluid volume is calculated with the fourquadrant technique done by ultrasound. 1,4 It is the sum of the maximum vertical fluid pockets (measured in cm) in each of the four quadrants. Quantitatively oligohydramnios is described as amniotic fluid index (AFI) <5 cm or <5 th percentile for the gestational age or 5-10 cm as borderline or single deepest pocket (SDP) <2 cm.…”

Section: Introductionmentioning

confidence: 99%

“…It plays a vital role in regulation of blood flow in vascular beds and placental perfusion, vasodilatation and platelet aggregation. 1 Because of these effects, it increases the volume and viscosity of blood in the feto-maternal circulation and promotes the intrauterine growth of the fetus (Figure 1). 1…”

Section: Introductionmentioning

confidence: 99%

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Efficacy of oral L-arginine on amniotic fluid index in pregnant women with oligohydramnios attending antenatal clinic in a tertiary care hospital in Telangana, India

Begum

Sowmya

Shailendra

et al. 2019

Int J Basic Clin Pharmacol

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Background: Oligohydramnios leads to feto-maternal morbidity and mortality. Though there is no specific treatment for oligohydramnios, use of L-arginine seems to be promising. As a nitric oxide donor, it causes vasodilatation, increases placental perfusion and finally increases amniotic fluid. However, data on the use of L-arginine for oligohydramnios is scarce. Hence, this study was aimed to evaluate the efficacy of oral L-arginine on Amniotic Fluid Index (AFI) and to document the pregnancy outcomes in women with oligohydramnios. Methods: This was a prospective observational study conducted on pregnant women attending antenatal clinic (ANC) at Results: A total of 50 participants were enrolled and 4 participants among them were lost to follow-up. Mean age (SD) of the women enrolled was 23.3 (3.49) years. Mean gestational age (SD) at the time of diagnosis was 34.61 (1.53) weeks. Mean AFI (SD) at the time of diagnosis and after treatment with L-arginine were 6.8 (1.3) cm and 9.4 (2.82) cm respectively. After a mean treatment duration (SD) of 3.23 (1.38) weeks, a mean (SD) increase of AFI by 2.6 (1.57) cm (P <0.0001) was observed. An increase of AFI was noted in 84.78% of cases (P <0.0001). Mean (SD) Gestational age at the time of delivery was 38.25 (1.48) weeks. Only 37% of participants required operational deliveries. Mean (SD) birth weight of the new borns was 2.54 (0.47) kg. Neonatal Intensive Care Unit (NICU) admissions were required in 32.6% of new borns. Conclusions: L-arginine is efficacious in improving AFI in oligohydramnios. AFI improvement could possibly lead to better neonatal outcomes by reducing preterm deliveries and operative interventions.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Efficacy of oral L-arginine on amniotic fluid index in pregnant women with oligohydramnios attending antenatal clinic in a tertiary care hospital in Telangana, India

Begum

Sowmya

Shailendra

et al. 2019

Int J Basic Clin Pharmacol

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Assessment of risk factors and predictors for spontaneous pre-term birth in a South Indian antenatal cohort

Rao

Bhat

Vandana

et al. 2018

Clinical Epidemiology and Global Health

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To assess incidence of spontaneous preterm births and determine biochemical and obstetric risk factors for spontaneous pre-term births in a cohort of antenatal women visiting a secondary care hospital. Methods: A prospective cohort study was designed to include 1420 pregnant women coming for antenatal care at a secondary care hospital. The cohort was followed throughout pregnancy and relevant history, obstetric and ultrasonographic examination and biochemical investigations was carried out in 2nd (20-24 weeks period of gestation) and 3rd trimester (28-32 weeks period of gestation). Outcome of delivery was noted for all the subjects. Results: A total of 1133 women were recruited. Among the 1071 respondents, 11 had abortions, 93.1% delivered at term while 5.9% had preterm deliveries. Preterm deliveries were noted among 6.5% women with short stature, 13.3% with cervical length <2.5 cms and 5.2% among women with anaemia. Statistically significant association was noted between Oligohydramnios, IUGR and preterm births. Salivary estriol was lower in women who had preterm births as compared to term births. Conclusions: The incidence of preterm births (5.9%) was low in the present cohort. Oligohydramnios and Intrauterine Growth Retardation (IUGR) were identified as significant risk factors for preterm births. Conventional risk factors like short cervix, short stature and biochemical inflammatory markers were not identified as predictors of prematurity. Lower levels of salivary estriol identified among women at risk of preterm births demonstrates the utility of the test as a non-invasive investigation for early identification of preterm births.

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The effect of maternal intravenous hydration on amniotic fluid index in oligohydramnios

et al. 2022

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Objective Assessing amniotic fluid determines an important dimension of fetal health. Significant relationships of oligohydramnios, which occurs in 1–2% of pregnancies, with abnormal pregnancy outcomes such as intrauterine growth retardation (IUGR), fetal anomalies, umbilical cord compression, fetal distress, preterm childbirth, meconium-stained amniotic fluid, perinatal mortality and cesarean section necessitate the measurement of amniotic fluid volume in many prenatal fetal health assessments. Amniotic fluid volume may significantly fluctuate between different gestational ages. Reduced uteroplacental perfusion can cause oligohydramnios by decreasing fetal renal blood flow and urine output. The appropriate management of isolated term oligohydramnios (ITO) is controversial. This study was performed aimed to assess the effect of maternal intravenous hydration on amniotic fluid index in oligohydramnios. Result Forty-eight hours after completing fluid therapy, statistically significant differences were observed in the mean AFI in the intervention group (4.06 ± 0.33) and the control group (3.61 ± 0.35) (P < 0.0001) and also between the intervention group (0.532 ± 0.45) and the controls (−0.036 ± 0.18) (P < 0.0001). Conclusion The results of the present study suggested that maternal intravenous hydration significantly increases AFI in women with oligohydramnios.

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Role of l-Arginine in Oligohydramnios

Cited by 8 publications

References 9 publications

Efficacy of oral L-arginine on amniotic fluid index in pregnant women with oligohydramnios attending antenatal clinic in a tertiary care hospital in Telangana, India

Efficacy of oral L-arginine on amniotic fluid index in pregnant women with oligohydramnios attending antenatal clinic in a tertiary care hospital in Telangana, India

Assessment of risk factors and predictors for spontaneous pre-term birth in a South Indian antenatal cohort

The effect of maternal intravenous hydration on amniotic fluid index in oligohydramnios

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