2021
DOI: 10.3390/microorganisms9030571
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Role of Leishmania infantum in Meningoencephalitis of Unknown Origin in Dogs from a Canine Leishmaniosis Endemic Area

Abstract: The main hypothesis for the aetiology of meningoencephalitis of unknown origin (MUO) in dogs is an autoimmune or genetic cause that is associated with a triggering event (environmental factors/infectious agents). The aim of this ambispective cohort study was to test for Leishmania infantum infection in the blood and cerebrospinal fluid (CSF) of dogs with MUO in an endemic area of canine leishmaniosis. Dogs with MUO were selected amongst all dogs undergoing blood anti-L. infantum antibody testing (control group… Show more

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Cited by 5 publications
(3 citation statements)
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“…Serum of canine blood samples (25 µL) was used for diagnosis at the Canine Leishmaniosis and Ehrlichiosis Diagnostic Service of the Complutense Veterinary Teaching Hospital of the Complutense University of Madrid. Serodiagnosis was performed by detecting specific antibodies against L. infantum using the indirect immunofluorescence antibody test (IFAT) for anti- Leishmania -specific immunoglobulin G (IgG) antibodies as previously described [ 34 – 36 ]. Antigen was obtained from a culture of promastigotes of L. infantum L-75 established in Novi, McNeal and Nicolle medium.…”
Section: Methodsmentioning
confidence: 99%
“…Serum of canine blood samples (25 µL) was used for diagnosis at the Canine Leishmaniosis and Ehrlichiosis Diagnostic Service of the Complutense Veterinary Teaching Hospital of the Complutense University of Madrid. Serodiagnosis was performed by detecting specific antibodies against L. infantum using the indirect immunofluorescence antibody test (IFAT) for anti- Leishmania -specific immunoglobulin G (IgG) antibodies as previously described [ 34 – 36 ]. Antigen was obtained from a culture of promastigotes of L. infantum L-75 established in Novi, McNeal and Nicolle medium.…”
Section: Methodsmentioning
confidence: 99%
“…Infected dogs can develop clinical disease (sick dogs), but they can also remain in the subclinical stage (clinically healthy infected dogs) [7,9,27]. Sick dogs feature clinical signs and/or clinicopathological abnormalities associated with leishmaniosis, which can affect any organ, tissue, or body fluid, with skin lesions being the most frequent manifestations [7,28,29], and which might be age-specific in some cases [30]. On the other hand, in endemic areas, there are also infected dogs, which do not feature clinical signs and/or clinicopathological abnormalities.…”
Section: Canine Leishmaniosis and Associated Immune Responses 1canine Leishmaniosismentioning
confidence: 99%
“…The pathogenesis of MUO is considered multifactorial and the main hypothesis for the etiology is an autoimmune cause triggered by environmental or infectious events [ 5 , 6 , 7 , 8 , 9 , 10 ]. The diagnosis of MUO is presumptive and magnetic resonance imaging (MRI), cerebrospinal fluid (CSF) analysis, and the exclusion of infectious agents are used to support the suspicion, although the definitive diagnosis is made only by histopathology [ 2 , 3 , 11 ].…”
Section: Introductionmentioning
confidence: 99%