Role of Leptin in Mood Disorder and Neurodegenerative Disease

Zou, Xiaohan; Zhong, Lili; Zhu, Cuilin; Zhao, Haisheng; Zhao, Fangyi; Cui, Ranji; Gao, Shengxiang; Li, Bingjin

doi:10.3389/fnins.2019.00378

Cited by 54 publications

(50 citation statements)

References 96 publications

(121 reference statements)

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“…Initially famous for its key role as a hormone, regulating body mass homeostasis, with its suppressive effect on food intake and its boosting action on metabolic rate, more recently, leptin's metabolism has been involved in many other processes and diseases [41,42]. This encompasses cancers, due to its pro-carcinogenic effects with action on cell development and suppression of apoptosis, neurodegenerative diseases, by its neuroprotective and neurotrophic effects in Alzheimer's disease, and some mental illnesses, including psychotic and mood disorders [41,42].…”

Section: Leptinmentioning

confidence: 99%

“…Modifications of leptin metabolism and its gene expression, as well as its receptor, have been reported among patients with mental health disorders, independently to psychotropic drugs or in absence of antipsychotics [43]. Several studies showed a particular interest in the relationship between leptin and depressive disorders, but with discordant conclusions [42][43][44][45].…”

Section: Leptin and Psychiatric Illnessesmentioning

confidence: 99%

“…However, a recent metaanalysis concluded that there is no difference in leptin levels between depressive subjects and controls [61]. Confounders such as age, gender-associated metabolic disturbances, medication history and clinical type of depressive disorders, might impact peripheral leptin levels, and thereby justify these inconsistent results [42,45]. Some other studies showed that leptin levels are increased in major depressive disorders, but only in patients experiencing atypical features, suggesting that leptin may be involved in a subset of patients with increased weight [62,63].…”

Section: Leptin and Psychiatric Illnessesmentioning

confidence: 99%

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Leptin and psychiatric illnesses: does leptin play a role in antipsychotic-induced weight gain?

et al. 2020

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Antipsychotic-induced weight gain is the most prevalent somatic adverse event occurring in patients treated by antipsychotics, especially atypical antipsychotics. It is of particular interest because of its repercussion on cardiovascular morbidity and mortality especially now that the use of second-generation antipsychotics has been extended to other mental health illnesses such as bipolar disorders and major depressive disorder. The mechanism underlying antipsychotics-induced weight gain is still poorly understood despite a significant amount of work on the topic. Recently, there has been an ongoing debate of tremendous research interest on the relationship between antipsychotic-induced weight gain and body weight regulatory hormones such as leptin. Given that, researchers have brought to light the question of leptin's role in antipsychotic-induced weight gain. Here we summarize and discuss the existing evidence on the link between leptin and weight gain related to antipsychotic drugs, especially atypical antipsychotics.

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Section: Leptinmentioning

confidence: 99%

Section: Leptin and Psychiatric Illnessesmentioning

confidence: 99%

Section: Leptin and Psychiatric Illnessesmentioning

confidence: 99%

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Leptin and psychiatric illnesses: does leptin play a role in antipsychotic-induced weight gain?

et al. 2020

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“…This data are supported by the observation that administration of leptin exerts an antidepressant-like effect [ 91 ], through dopaminergic neurotransmission regulation in mesolimbic areas [ 92 ]. In particular, leptin reduces symptoms of depression and has an anxiolytic effect affecting the HPA [ 93 , 94 ], and stimulating brain-derived neurotrophic factor (BDNF) production and function [ 95 , 96 , 97 ]. In addition, the deletion of leptin receptor (LepRb) and its downregulation are associated with depression-like behavioral impairments, indicating that leptin-lepRb signaling is involved in the molecular mechanism of leptin antidepressant action [ 98 , 99 ].…”

Section: Adipokinesmentioning

confidence: 99%

Depression and Cardiovascular Disease: The Viewpoint of Platelets

Amadio

Zara

Sandrini

et al. 2020

IJMS

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Depression is a major cause of morbidity and low quality of life among patients with cardiovascular disease (CVD), and it is now considered as an independent risk factor for major adverse cardiovascular events. Increasing evidence indicates not only that depression worsens the prognosis of cardiac events, but also that a cross-vulnerability between the two conditions occurs. Among the several mechanisms proposed to explain this interplay, platelet activation is the more attractive, seeing platelets as potential mirror of the brain function. In this review, we dissected the mechanisms linking depression and CVD highlighting the critical role of platelet behavior during depression as trigger of cardiovascular complication. In particular, we will discuss the relationship between depression and molecules involved in the CVD (e.g., catecholamines, adipokines, lipids, reactive oxygen species, and chemokines), emphasizing their impact on platelet activation and related mechanisms.

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“…Leptin and ghrelin have also been implicated in neuropsychiatric disorders [ 30 , 31 , 32 ] and might lie at the very crossroads between obesity and mood. Therefore, they are of special interest in regard to FC in affective disorders.…”

Section: Introductionmentioning

confidence: 99%

The Relationship Between Food Craving, Appetite-Related Hormones and Clinical Parameters in Bipolar Disorder

et al. 2020

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Obesity and weight gain in bipolar disorder (BD) have multifactorial underlying causes such as medication side effects, atypical depressive symptomatology, genetic variants, and disturbances in the neuro-endocrinal system. Therefore, we aim to explore the associations between food craving (FC), clinical parameters, psychotropic medication, and appetite-related hormones. In this cross-sectional investigation, 139 individuals with BD and 93 healthy controls (HC) completed the food craving inventory (FCI). In addition, blood samples (including leptin and acylated ghrelin) were analyzed and sociodemographic and anthropometric data were collected. Individuals with BD reported higher frequencies of total FC as well as craving for fat and fast food than HC. Additionally, we found a significant negative correlation between FC and ghrelin levels in BD. Smokers with BD reported significantly more craving for high fat foods than non-smokers. Age was significantly associated with FC independent of group. Individuals with BD taking olanzapine and quetiapine reported higher frequencies of craving for sweet food, while patients currently taking lithium reported less total FC compared to those without lithium therapy. Likewise, patients currently taking valproate reported less total FC and less craving for sweets than those not taking valproate. FC appears to be of clinical relevance in individuals with BD. Contrary to previous data, this does not seem to be a female phenomenon only and might encompass more than the specific craving for carbohydrates. Although due to the cross sectional design, causality cannot be determined, the association between depressive symptomatology and fast food craving warrants further research.

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Role of Leptin in Mood Disorder and Neurodegenerative Disease

Cited by 54 publications

References 96 publications

Leptin and psychiatric illnesses: does leptin play a role in antipsychotic-induced weight gain?

Leptin and psychiatric illnesses: does leptin play a role in antipsychotic-induced weight gain?

Depression and Cardiovascular Disease: The Viewpoint of Platelets

The Relationship Between Food Craving, Appetite-Related Hormones and Clinical Parameters in Bipolar Disorder

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