Role of Leptin in Pregnancy—A Review

Sagawa, Norimasa; Yura, Shigeo; Itoh, Hiroshi; Mise, Hiroko; Kakui, Kazuyo; Korita, Daizo; Takemura, Masanori; Nuamah, Mercy A.; Ogawa, Yoshihiro; Masuzaki, Hiroaki; Nakao, Kazuwa; Fujii, Shingo

doi:10.1053/plac.2002.0814

Cited by 149 publications

(116 citation statements)

References 45 publications

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“…Fetal leptin, originating in the placental trophoblast (Chen et al 2000) or in fetal adipose tissues (Lepercq et al 2001), is firmly associated with conceptus growth and development in a number of species, including humans (Bajoria et al 2002, Henson & Castracane 2002, Sagawa et al 2002. Effects are mediated in a variety of tissues via a specific leptin receptor, which is a member of the cytokine class I receptor superfamily.…”

Section: Discussionmentioning

confidence: 99%

“…Proposed roles for this multifaceted polypeptide include regulating trophoblast invasion and endocrinology, fetal and placental growth, angiogenesis, hematopoiesis, fetal bone development, and the maturation of the fetal immune system. Indeed, acting via autocrine and/or paracrine mechanisms, leptin may be an important factor in the maintenance of pregnancy itself (Bajoria et al 2002, Henson & Castracane 2002, Sagawa et al 2002.…”

Section: Introductionmentioning

confidence: 99%

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Leptin receptor expression in fetal lung increases in late gestation in the baboon: a model for human pregnancy

Henson

Swan²,

Edwards³

et al. 2004

Reproduction

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Leptin produced by both adipose tissue and the placental trophoblast, has been proposed to regulate numerous aspects of human conceptus development. Although recent animal studies have suggested an additional role for the polypeptide in fetal lung maturation, no evidence has been reported in primates. Therefore, we employed the baboon (Papio sp.), a well-characterized primate model for human pregnancy, to determine the presence and ontogeny of leptin receptor in fetal lung with advancing gestation. Lungs were collected from fetal baboons, early in gestation (days 58-62, n 5 4), at mid gestation (days 98 -102, n 5 4), and late in gestation (days 158 -165, n 5 4) (term 184 days). mRNA transcripts for leptin (LEP) and both long and short intracellular domain isoforms of the leptin receptor (LEP-R L and LEP-R S ) were assessed by RT-PCR. leptin receptor protein was evaluated by immunoblotting and cell types expressing leptin receptor were identified in late pregnancy by immunohistochemistry. Fetal serum leptin concentrations, determined by RIA, remained relatively unchanged at 5.7 6 1.1 ng/ml (mean 6 S.E.M.) in mid pregnancy and 8.4 6 3.0 ng/ml in late pregnancy (P > 0.05). Although leptin were detectable in fetal lung, no changes in transcript abundance were apparent with advancing gestation. However, transcripts for both LEP-R L and LEP-R S receptor isoforms increased several-fold (P < 0.05) in fetal lung between mid and late gestation, while leptin receptor protein was detectable only in late pregnancy. leptin receptor was localized in distal pulmonary epithelial cells, including type II pneumocytes. In conclusion, leptin is present in the fetal baboon and its receptor is enhanced during late gestation in cells responsible for the synthesis of pulmonary surfactant. Collectively, these and past findings may suggest a modulatory role for the polypeptide in pulmonary development and/or may identify leptin receptor as a physiological marker of primate fetal lung maturity.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Leptin receptor expression in fetal lung increases in late gestation in the baboon: a model for human pregnancy

Henson

Swan²,

Edwards³

et al. 2004

Reproduction

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“…The plasma concentration of leptin is associated with the extent of obesity (Bouloumié et al 1998). Biologically, leptin is regarded as a multifunctional hormone that is involved in various body functions such as hematopoiesis, osteogenesis, thermogenesis, angiogenesis, chondrogenesis, neuroendocrine processes, arterial pressure control, body weight homeostasis and immune functions (Fantuzzi and Faggioni 2000;Pérez-Pérez et al 2015;Sagawa et al 2002). The synthesis of leptin by various tissues and organs such as the pituitary, placenta, stomach, and skeletal muscle is consistent with its biological roles in these body systems (Reitman et al 2001).…”

Section: Leptin Receptor Signaling and Atimentioning

confidence: 99%

Acute Thymic Involution and Mechanisms for Recovery

Ansari

Liu

2017

Arch. Immunol. Ther. Exp.

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“…In fact, insulin is an inducer of leptin production in human placenta as shown in vivo [84], enhancing the activity of leptin promoter region [85]. This may be relevant in gestational diabetes [6,86,112,127], a state of greater insulin resistance and hyperinsulinemia than normal pregnancies. In this line, numerous studies have reported that circulating leptin levels, as well as placental leptin and LEPR expression are significantly higher in pregnant women with GDM compared to healthy control women with uncomplicated pregnancy [128,129], providing, at least, a molecular mechanism for the placenta overgrowth previously observed in GDM [99,100].…”

Section: Role Of Leptin In Pregnancymentioning

confidence: 99%

“…Plasma levels of leptin are correlated with the degree of obesity and are regulated by feeding and fasting. At present, leptin is considered to be a multifunctional hormone that regulates not only body weight homeostasis, but also thermogenesis, angiogenesis, hematopoiesis, osteogenesis, chondrogenesis, neuroendocrine, and immune functions, as well as arterial pressure control [3][4][5][6]. These actions of leptin are consistent with its production by various tissues and organs, such as the stomach, skeletal muscle, pituitary cells and the placenta [7].…”

Section: Introductionmentioning

confidence: 99%

Role of leptin in female reproduction

Pérez-Pérez

Sánchez-Jiménez

Maymó

et al. 2015

Clinical Chemistry and Laboratory Medicine (CCLM)

127

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Abstract:Reproductive function is dependent on energy resources. The role of weight, body composition, fat distribution and the effect of diet have been largely investigated in experimental female animals as well as in women. Any alteration in diet and/or weight may induce abnormalities in timing of sexual maturation and fertility. However, the cellular mechanisms involved in the fine coordination of energy balance and reproduction are largely unknown. The brain and hypothalamic structures receive endocrine and/or metabolic signals providing information on the nutritional status and the degree of fat stores. Adipose tissue acts both as a store of energy and as an active endocrine organ, secreting a large number of biologically important molecules termed adipokines. Adipokines have been shown to be involved in regulation of the reproductive functions. The first adipokine described was leptin. Extensive research over the last 10 years has shown that leptin is not only an adipose tissue-derived messenger of the amount of energy stores to the brain, but also a crucial hormone/cytokine for a number of diverse physiological processes, such as inflammation, angiogenesis, hematopoiesis, immune function, and most importantly, reproduction. Leptin plays an integral role in the normal physiology of the reproductive system with complex interactions at all levels of the hypothalamic-pituitary gonadal (HPG) axis. In addition, leptin is also produced by placenta, where it plays an important autocrine function. Observational studies have demonstrated that states of leptin excess, deficiency, or resistance can be associated with abnormal reproductive function. This review focuses on the leptin action in female reproduction.

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Role of Leptin in Pregnancy—A Review

Cited by 149 publications

References 45 publications

Leptin receptor expression in fetal lung increases in late gestation in the baboon: a model for human pregnancy

Leptin receptor expression in fetal lung increases in late gestation in the baboon: a model for human pregnancy

Acute Thymic Involution and Mechanisms for Recovery

Role of leptin in female reproduction

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