Role of leptin in the pathophysiology of preeclampsia

Zeng, Shuai; Liu, Yijun; Fan, Ping; Yang, Luming; Liu, Xinghui

doi:10.1016/j.placenta.2023.09.005

Cited by 9 publications

(3 citation statements)

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“…Although there are no reference values for leptin levels in the placenta, our results did not show a correlation between placental and blood leptin levels. This finding is consistent with previous data that did not find a correlation between leptin concentrations in maternal plasma and cord blood at birth [24]. However, some studies showed that almost all placental leptin is released into the maternal bloodstream (about 90%) [25,26].…”

Section: Discussionsupporting

confidence: 93%

“…The authors found a consistent association between maternal blood leptin and pre-gestational and final BMI in women with uncomplicated pregnancy [22]. Other studies also confirmed that weight and adiposity gain are important factors for increasing circulating leptin levels in women presenting gestational diabetes and pre-eclampsia [19,23,24].…”

Section: Discussionmentioning

confidence: 72%

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The Potential Role of Leptin in the Regulation of Maternal Weight during Pregnancy and Its Impact on Neonate Weight and Apgar

Fonseca,

Souza-Carmo,

Ruas

et al. 2024

Obesities

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Leptin is secreted by adipose tissue and expressed in several organs, including the placenta. We investigated the influence of leptin in maternal blood on leptin expression and concentration in the placenta and umbilical cord and its influence on fetal weight and conditions at the time of birth. Twenty-five parturients were recruited, and after childbirth, placental tissue fragments, umbilical arteries, and vein blood were collected. According to leptin concentration in maternal peripheral blood, parturients were divided into low and high leptin groups. Mothers in the high-leptin group had higher age, pre-pregnancy weight, pre-pregnancy BMI, and weight in late pregnancy than mothers in the low-leptin group. Children of mothers in the high-leptin group presented an Apgar score modestly lower than those of the low-leptin group. No differences were observed in leptin concentrations in the umbilical artery and vein. However, the leptin retained in the fetus increased in the high-leptin group compared to the low-leptin group. We observed a negative correlation between fetal leptin retained and maternal age in the low-leptin group. In the high-leptin group, placental leptin concentration was positively correlated with maternal weight in late pregnancy. Nonetheless, the expression of the leptin receptor (Ob-Rb) was negatively correlated with newborn length. In conclusion, this study found a positive correlation between maternal leptin levels and maternal pre-pregnancy weight, BMI, and fetal birth weight. These findings suggest a potential role of leptin in maternal weight regulation during pregnancy and fetal growth.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 72%

The Potential Role of Leptin in the Regulation of Maternal Weight during Pregnancy and Its Impact on Neonate Weight and Apgar

Fonseca,

Souza-Carmo,

Ruas

et al. 2024

Obesities

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“…While the potential of LEP protein, rather than its mRNA, as a potential biomarker has been suggested previously, its presence in STB-EVs adds a new dimension ( 19 ). LEP plays a role in endocrine functions, reproduction, immune function, and is produced by the placenta, aiding implantation and regulating placental growth ( 20 ). Leptin dysregulation has been linked to pregnancy complications with higher circulating protein levels associated with PE ( 21 ).…”

Section: Discussionmentioning

confidence: 99%

A cross-sectional analysis of syncytiotrophoblast membrane extracellular vesicles–derived transcriptomic biomarkers in early-onset preeclampsia

Awoyemi,

Zhang,

Rahbar

et al. 2023

Front. Cardiovasc. Med.

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BackgroundPreeclampsia (PE) is a pregnancy-specific hypertensive disorder affecting 2%–8% of pregnancies worldwide. Biomarker(s) for the disorder exists, but while these have excellent negative predictive value, their positive predictive value is poor. Extracellular vesicles released by the placenta into the maternal circulation, syncytiotrophoblast membrane extracellular vesicles (STB-EVs), have been identified as being involved in PE with the potential to act as liquid biopsies.ObjectiveThe objective of this study was to identify the difference in the transcriptome of placenta and STB-EVs between preeclampsia and normal pregnancy (NP) and mechanistic pathways.Methods/study designWe performed RNA-sequencing on placental tissue, medium/large and small STB-EVs from PE (n = 6) and NP (n = 6), followed by bioinformatic analysis to identify targets that could be used in the future for EV-based diagnostic tests for preeclampsia. Some of the identified biomarkers were validated with real-time polymerase chain reactions.ResultsOur analysis identified a difference in the transcriptomic STB-EV cargo between PE and NP. We then identified and verified the differential expression of FLNB, COL17A1, SLC45A4, LEP, HTRA4, PAPP-A2, EBI3, HSD17B1, FSTL3, INHBA, SIGLEC6, and CGB3. Our analysis also identified interesting mechanistic processes via an in silico prediction of STB-EV-based mechanistic pathways.ConclusionsIn this study, using comprehensive profiling of differentially expressed/carried genes of three linked sample subtypes in PE, we identified potential biomarkers and mechanistic gene pathways that may be important in the pathophysiology of PE and could be further explored in future studies.

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