Role of Leu72Met of GHRL and Gln223Arg of LEPR Variants on Food Intake, Subjective Appetite, and Hunger-Satiety Hormones

Sanchez-Murguia, Tania; Torres-Castillo, Nathaly; Vega, Lisset Magaña-de la; Rodríguez-Reyes, Sarai Citlalic; Campos-Pérez, Wendy; Martínez‐López, Erika

doi:10.3390/nu14102100

Cited by 5 publications

(2 citation statements)

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“…The breakfast design has been previously reported [30]. The breakfast was prepared at the “CUCSINE, Laboratorio de Gestión de Servicios de Alimentos, Centro de Universitario de Ciencias de la Salud, Universidad de Guadalajara,” and consisted of 526 kilocalories of which 43% were carbohydrates, 36% were fat, and 21% were protein.…”

Section: Methodsmentioning

confidence: 99%

<i>FTO</i> genotypes (rs9939609 T>A) are Associated with Increased Added Sugar Intake in Healthy Young Adults

Madrigal-Juarez,

Martínez-López,

Sanchez-Murguia

et al. 2023

Lifestyle Genomics

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Introduction: Single-nucleotide polymorphism (SNP) rs9939609 in the FTO gene has been associated with dietary intake and appetite traits mainly in participants with obesity, however it remains widely unexplored in normal weight participants. Thus, the aims of this study were 1) to compare the changes in subjective appetite sensations, ghrelin, and insulin concentrations according to the SNP rs9939609 T>A in FTO and 2) to compare dietary intake between rs9939609 genotype groups in normal weight young participants. Methods: We conducted a quasi-experimental study involving 88 normal-weight participants to analyze subjective perception of appetite, hormonal response for hunger and satiety, and dietary intake according to the rs9939609 SNP. Participants received a standardized single breakfast. Visual Analogue Scales (VAS) were utilized for assessing the subjective perception of appetite at fasting and immediately after breakfast and at 30, 60, 90, and 120 minutes postprandially. Glucose, lipid profile, ghrelin, and insulin were measured at fasting and at 120 minutes after breakfast. Dietary intake was assessed with a 3-day food record. The SNP was determined by allelic discrimination with TaqMan probes. To compare dietetic, biochemical, and the subjective appetite sensations, Student T test, ANCOVA test, and the repeated measures ANOVA were used. The linear regression model and the linear mixed model were used for the association analysis. Pearson correlation was used to test the correlation between two quantitative variables. Results: A total of 88 people participated, 81.8% were female, with a mean BMI of 21.8 ± 2.0 kg/m2 and a mean age of 20.6 ± 2.0. Genotype frequencies of the rs9939609 SNP were 52 % for the TT allele and 48 % for the TA/AA. The subjective perception of appetite named hunger, fullness, satiety, desire to eat, and prospective food consumption were similar between genotypes of the rs9939609. Participants with the TA/AA genotype showed a higher intake of added sugar (p=0.039) than TT participants. No differences were found in ghrelin, insulin, glucose, or lipid parameters between genotypes. Conclusion: Carriers of the A allele from FTO gene SNP rs9939609 may have an increased preference for foods, specifically for added sugars.

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Section: Methodsmentioning

confidence: 99%

<i>FTO</i> genotypes (rs9939609 T>A) are Associated with Increased Added Sugar Intake in Healthy Young Adults

Madrigal-Juarez,

Martínez-López,

Sanchez-Murguia

et al. 2023

Lifestyle Genomics

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“…The rs696217 polymorphism (Leu72Met) of the GHRL gene affects hunger and satiety. Individuals with the Met72Met genotype exhibit greater consumption of sugars and bread compared to carriers of the Leu72Leu genotype ( 25 ). There is evidence that individuals showing genetic risk factors exhibit varying scores related to “food approach” and “food avoidant” appetitive traits, as observed among 180 young Mexican subjects, where circulating IgG autoAbs reacting to ghrelin and leptin were evaluated ( 26 ).…”

Section: Introductionmentioning

confidence: 99%

Relationship between energy balance and reward system gene polymorphisms and appetitive traits in young Mexican subjects

Rivera-Iñiguez,

Hunot-Alexander,

Sepúlveda-Villegas

et al. 2024

Front. Nutr.

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IntroductionAppetitive traits are influenced by the interplay between genetic and environmental factors. This study aimed to explore the relationship between gene polymorphisms involved in the regulation of energy balance and food reward and appetitive traits in young Mexican subjects.MethodsThis cross-sectional study involved 118 university freshman undergraduates who completed the Adult Eating Behaviour Questionnaire for Spanish speakers (AEBQ-Esp) to assess their appetitive traits. A real-time PCR system was employed to determine gene polymorphisms involved in energy balance (LEP rs7799039, MC4R rs17782313, FTO rs9939609, GHRL rs696217), and reward system (DRD2/ANKK1 Taq1A rs1800497 and COMT rs4680).ResultsThe mean age of participants was 20.14 ± 3.95 years, 71.2% were women and their mean BMI was 23.52 ± 4.05 kg/m2. COMT Met allele carriers presented a significantly higher “Emotional overeating” mean score than Val allele carriers (2.63 ± 0.70 vs. 2.23 ± 0.70, p = 0.028). The MC4R CC + CT genotype correlated positively with “Emotional overeating” (Phi = 0.308, p = 0.01). The COMT MetMet+MetVal genotype correlated with higher “Emotional overeating” (r = 0.257, p = 0.028; Phi = 0.249, p = 0.033). The protective genotype FTO TT correlated positively with “Emotional undereating” (Phi = 0.298, p = 0.012). Carriers of the risk genotype MC4R CC + CT presented a higher risk of “Emotional overeating” than TT carriers (OR = 2.4, 95% CI 1.3–4.8, p = 0.034). Carriers of the risk genotype COMT MetMet+MetVal (OR = 3.4, 95% CI 1.1–10.3, p = 0.033), were associated with a higher risk of “Emotional overeating” than ValVal carriers. The protective FTO genotype TT was associated with “Emotional undereating” (OR = 1.8, 95% CI 1.1–9.1, p = 0.014).DiscussionThe study found a relationship between the protective genotypes of FTO TT and “Emotional undereating” and risk genotypes of COMT Met/Met+Met/Val and MC4R CC + CT with “Emotional overeating.” These genetic factors may increase weight gain by enhancing hedonic food consumption and reducing satiety control. Future studies should focus on replication studies in ethnically diverse young adults and life stages to explore the relationship between polymorphisms and appetitive traits and weight. This will help tailor personalized nutrigenetic strategies to counteract disordered eating patterns leading to obesity and associated co-morbidities.

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Genetic variants in ghrelin (rs27647, rs696217) and leptin (rs7799039) are not associated with body composition parameters but are related to appetitive traits in Mexican young adults

Espinoza García,

Díaz Chávez,

Valdés Miramontes

et al. 2024

Gene Reports

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Role of Leu72Met of GHRL and Gln223Arg of LEPR Variants on Food Intake, Subjective Appetite, and Hunger-Satiety Hormones

Cited by 5 publications

References 50 publications

<i>FTO</i> genotypes (rs9939609 T>A) are Associated with Increased Added Sugar Intake in Healthy Young Adults

<i>FTO</i> genotypes (rs9939609 T>A) are Associated with Increased Added Sugar Intake in Healthy Young Adults

Relationship between energy balance and reward system gene polymorphisms and appetitive traits in young Mexican subjects

Genetic variants in ghrelin (rs27647, rs696217) and leptin (rs7799039) are not associated with body composition parameters but are related to appetitive traits in Mexican young adults

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Role of Leu72Met of GHRL and Gln223Arg of LEPR Variants on Food Intake, Subjective Appetite, and Hunger-Satiety Hormones

Cited by 5 publications

References 50 publications

<i>FTO</i> genotypes (rs9939609 T&gt;A) are Associated with Increased Added Sugar Intake in Healthy Young Adults

<i>FTO</i> genotypes (rs9939609 T&gt;A) are Associated with Increased Added Sugar Intake in Healthy Young Adults

Relationship between energy balance and reward system gene polymorphisms and appetitive traits in young Mexican subjects

Genetic variants in ghrelin (rs27647, rs696217) and leptin (rs7799039) are not associated with body composition parameters but are related to appetitive traits in Mexican young adults

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Product

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<i>FTO</i> genotypes (rs9939609 T>A) are Associated with Increased Added Sugar Intake in Healthy Young Adults

<i>FTO</i> genotypes (rs9939609 T>A) are Associated with Increased Added Sugar Intake in Healthy Young Adults