Role of life events in the presence of colon polyps among African Americans

Ashktorab, Hassan; Namin, Hassan Hassanzadeh; Taylor, Teletia R.; Williams, Carla; Brim, Hassan; Mellman, Thomas A.; Shokrani, Babak; Holt, Cheryl L.; Laiyemo, Adeyinka O.; Nouraie, Mehdi

doi:10.1186/1471-230x-13-101

Cited by 8 publications

(2 citation statements)

References 26 publications

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“…Patients who had previously colonoscopies with polyps removed and admitted for follow-up were so-called “follow-up colonoscopies”. Patients undergoing colonoscopies for symptoms such as abdominal pain or rectal bleeding were defined as “diagnostic colonoscopies” [30].…”

Section: Methodsmentioning

confidence: 99%

Obesity, diabetes and the risk of colorectal adenoma and cancer

et al. 2019

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BackgroundColorectal cancer (CRC) is the fourth most commonly diagnosed gastrointestinal (GI) malignancy and the third leading cause of cancer-related death worldwide. In the current case-control study, an association between diagnosis of CRC, obesity and diabetes was investigated.MethodsDemographic characteristics, colonoscopy reports, history of drug, smoking, and medical history were collected from patients referred to a colonoscopy unit. The location, size and number of the polyps were recorded during the colonoscopy. Statistically, t-test was conducted for mean comparison for the groups. Pearson’s chi-squared test (χ2) was applied to categorize variables. Five classification methods based on the important clinicopathological characteristics such as age, BMI, diabetes, family history of colon cancer was performed to predict the results of colonoscopy.ResultsOverall, 693 patients participated in this study. In the present study, 115 and 515 patients were evaluated for adenoma/adenocarcinoma and normal colonoscopy, respectively. The mean age of patients positive for adenoma or adenocarcinoma were significantly higher than the negative groups (p value < 0.001). Incidence of overweight and/or obesity (BMI > 25 kg/m2) were significantly higher in adenoma positive patients as compared to controls (49.9 and 0.9% respectively, p value = 0.04). The results also demonstrated a significant association between suffering from diabetes and having colon adenoma (OR = 1.831, 95%CI = 1.058–3.169, p value = 0.023). The experimental results of 5 classification methods on higher risk factors between colon adenoma and normal colonoscopy data were more than 82% and less than 0.42 for the percentage of classification accuracy and root mean squared error, respectively.ConclusionsIn the current study, the occurrence of obesity measured based on BMI and diabetes in the adenoma positive patient group was significantly higher than the control group although there was no notable association between obesity, diabetes and adenocarcinoma.

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Section: Methodsmentioning

confidence: 99%

Obesity, diabetes and the risk of colorectal adenoma and cancer

et al. 2019

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“…A study highlighted the association of total stressful life events and colon polyps in African Americans, supporting the evidence that stress hormones alter the rate of cell growth and proliferation [45]. A study based on a multiethnic colorectal screening [46] observed that individuals with an active lifestyle showed a significantly lower prevalence of adenoma risk, compared to counterparts who had reduced physical activity and demonstrated the development of adenomas in distal colon prevalently.…”

Section: Modifiable Factorsmentioning

confidence: 90%

Molecular Aspects of Colorectal Adenomas: The Interplay among Microenvironment, Oxidative Stress, and Predisposition

Aceto

Catalano

Curia

2020

BioMed Research International

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The development of colorectal cancer (CRC) is a multistep process initiated by a benign polyp that has the potential to evolve into in situ carcinoma through the interactions between environmental and genetic factors. CRC incidence rates are constantly increased for young adult patients presenting an advanced tumor stage. The majority of CRCs arise from colonic adenomas originating from aberrant cell proliferation of colon epithelium. Endoscopic polypectomy represents a tool for early detection and removal of polyps, although the occurrence of cancers after negative colonoscopy shows a significant incidence. It has long been recognized that the aberrant regulation of Wingless/It (Wnt)/β-Catenin signaling in the pathogenesis of colorectal cancer is supported by its critical role in the differentiation of stem cells in intestinal crypts and in the maintenance of intestinal homeostasis. For this review, we will focus on the development of adenomatous polyps through the interplay between renewal signaling in the colon epithelium and reactive oxygen species (ROS) production. The current knowledge of molecular pathology allows us to deepen the relationships between oxidative stress and other risk factors as lifestyle, microbiota, and predisposition. We underline that the chronic inflammation and ROS production in the colon epithelium can impair the Wnt/β-catenin and/or base excision repair (BER) pathways and predispose to polyp development. In fact, the coexistence of oxidative DNA damage and errors in DNA polymerase can foster C>T transitions in various types of cancer and adenomas, leading to a hypermutated phenotype of tumor cells. Moreover, the function of Adenomatous Polyposis Coli (APC) protein in regulating DNA repair is very important as therapeutic implication making DNA damaging chemotherapeutic agents more effective in CRC cells that tend to accumulate mutations. Additional studies will determine whether approaches based on Wnt inhibition would provide long-term therapeutic value in CRC, but it is clear that APC disruption plays a central role in driving and maintaining tumorigenesis.

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Inflammatory potential of the diet

Wirth

Burch

2022

Diet, Inflammation, and Health

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Role of life events in the presence of colon polyps among African Americans

Cited by 8 publications

References 26 publications

Obesity, diabetes and the risk of colorectal adenoma and cancer

Obesity, diabetes and the risk of colorectal adenoma and cancer

Molecular Aspects of Colorectal Adenomas: The Interplay among Microenvironment, Oxidative Stress, and Predisposition

Inflammatory potential of the diet

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