Role of lipoic acid in reducing the oxidative stress induced by cyclosporine A

Amudha, Ganapathy; Josephine, Anthony; Varalakshmi, P.

doi:10.1016/j.cca.2006.03.036

Cited by 47 publications

(39 citation statements)

References 37 publications

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“…The obtained results are in agreement with the finding of Amudha et al 2 The hepatotoxicity induced by CsA in this study is characterized by increasing serum AST to 193% and ALT to 258% as compared to the control and confirmed by histopathological examination of hepatic tissue, which showed large necrotic areas surrounded by erythrocytes and congested blood vessels. These results are in accordance with the finding of Kurus et al 5 CsA exposure enhances intracellular ROS/RNS production, suggesting that biochemical and physiological disturbances may result from oxidative and nitrosative stress.…”

Section: Protective Effect Of Trapidil and L-arginine 965supporting

confidence: 93%

“…3 Both ROS/RNS are considered as signaling mediators in the pathophysiology of CsA toxicity. 2 This study demonstrated that CsA exposure significantly elevated serum levels of IL-1b, TNF-a, and MCP-1. These results are in harmony with the previous findings of Ramesh and Reaves 35 and can be discussed on the basis that TNF-a and IL-1b are pro-inflammatory cytokines and often elevated in parallel.…”

Section: Protective Effect Of Trapidil and L-arginine 965mentioning

confidence: 62%

“…However, despite the wide spectrum of CsA clinical uses, evidences have accumulated that it is associated with major adverse effects, the most important being renal and hepatic toxicity in humans and experimental animals. 2 The mechanisms by which CsA causes nephrotoxicity and hepatotoxicity are poorly understood; however, numerous studies have shown that CsA exposure enhances intracellular reactive oxygen/ nitrogen species (ROS/RNS) production, suggesting that biochemical and physiological disturbances may result from oxidative and nitrosative stress. 3 Release of vasoconstrictor prostaglandins such as thromboxane A 2 and activation of the sympathetic nervous system are the candidates of cyclosporine-induced vasoconstriction.…”

Section: Introductionmentioning

confidence: 99%

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Protective effect of trapidil andl-arginine against renal and hepatic toxicity induced by cyclosporine in rats

Salem

Maarouf

et al. 2010

Renal Failure

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(2010) Protective effect of trapidil and l-arginine against renal and hepatic toxicity induced by cyclosporine in rats, Renal Failure, 32:8,[959][960][961][962][963][964][965][966][967][968] DOI: 10.3109 CsA induced renal and hepatic dysfunction, which was confirmed by laboratory and histopathological examination. Administration of trapidil diminished the renal and liver injury and significantly attenuated the levels of serum creatinine, urea, aspartate aminotransferase (AST), alanine aminotransferase (ALT), interleukin1b (IL-1b), tumor necrosis factor alpha (TNF-a), monocyte chemoattractant protein-1 (MCP-1), and oxidative stress, while it significantly elevated the level of serum nitric oxide and the activity of antioxidative stress. L-Arginine gave the same trend as trapidil, but trapidil effect was more pronounced. Coadministration of trapidil + L-arginine significantly ameliorated the toxic effect of CsA, but did not differ significantly from the effect of trapidil alone. Conclusions: Treatment with trapidil or L-arginine diminished the renal and hepatic CsA-induced toxicity. However, the effect of trapidil was more pronounced. Therefore, treatment with trapidil alone may be the most economic and effective as a potential therapeutic agent in CsA injury.

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Section: Protective Effect Of Trapidil and L-arginine 965supporting

confidence: 93%

Section: Protective Effect Of Trapidil and L-arginine 965mentioning

confidence: 62%

Section: Introductionmentioning

confidence: 99%

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Protective effect of trapidil andl-arginine against renal and hepatic toxicity induced by cyclosporine in rats

Salem

Maarouf

et al. 2010

Renal Failure

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“…Various antioxidants such as melatonin (Rezzani et al 2005), lycopene (Atessahin et al 2006), lipoic acid (Amudha et al 2006) and green tea (Mohamadin et al 2005) have been investigated for their potential effects to prevent the side effects of toxic substances. There is another type of antioxidants, flavonoids, which are richly found in fruits and vegetables.…”

Section: Discussionmentioning

confidence: 99%

Protective effects of ellagic acid in d-galactosamine-induced kidney damage in rats

et al. 2015

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D-Galactosamine (D-GalN), which is an established experimental toxin, primarily causes liver injury by the generation of free radicals and depletion of UTP nucleotides. D-GalN intoxication also induces renal dysfunction thus, renal failure is often associated with the end-stage of the liver damage. We have investigated both preventive and curative effects of ellagic acid (EA) in this study. EA treatment at a gavage dose of 20 mg/kg body weight was administered before and after intraperitoneal (i.p.) injection of D-GalN at a dose of 750 mg/kg. Tissue and blood samples of animals were collected for morphological and biochemical evaluations. Our study results suggest that EA treatment both prior to and after the toxin administration successfully altered the toxic effects on the rats. Moreover, pre-treatment of EA was more protective than post-treatment indicated by histopathological and biochemical values. In conclusion, EA treatment both before and after D-GalN intoxication could protect kidney tissues against D-GalN induced oxidative stress.

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“…It seems that some deal of this activity may be due to its aptitude to chelation of metal ions and recycling of other cellular antioxidants, such as vitamin C and E, and glutathione [9,23,43].…”

Section: Discussionmentioning

confidence: 99%

The effect of alpha lipoic acid on the developmental competence of mouse isolated preantral follicles

Talebi

Zavareh

Kashani

et al. 2012

J Assist Reprod Genet

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Purpose This study was designed to investigate the effect of alpha-lipoic acid (ALA) on reactive oxygen species (ROS) production, total antioxidant capacity (TAC) and developmental competence of cultured pre-antral follicles derived from mouse ovarian tissue. Methods Pre-antral follicles were isolated from immature mouse ovaries and were cultured in α-minimal essential medium supplemented with different concentrations (0, 50, 100, 250 and 500 uM) of ALA. Follicular growth, oocyte maturation and embryo development were evaluated. Separately, ROS and TAC were measured after 0, 24, 48, 72 and 96 h of culture with spectrofluorometery and ferric reducing/antioxidant power (FRAP) assay, respectively. Results In the presence of 100 uM ALA, developmental rates of follicles, oocytes and embryos were significantly higher than other groups (p<0.05). At 96 h after culture, a decrease in ROS and an increase in TAC were observed in ALA group compared to control group (p<0.05). Conclusion ALA (100 uM) improves the in vitro development of follicles. This effect may be mediated by decreasing ROS concentration and increasing follicular TAC level during the culture period.

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Role of lipoic acid in reducing the oxidative stress induced by cyclosporine A

Cited by 47 publications

References 37 publications

Protective effect of trapidil andl-arginine against renal and hepatic toxicity induced by cyclosporine in rats

Protective effect of trapidil andl-arginine against renal and hepatic toxicity induced by cyclosporine in rats

Protective effects of ellagic acid in d-galactosamine-induced kidney damage in rats

The effect of alpha lipoic acid on the developmental competence of mouse isolated preantral follicles

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