Role of LncRNA NEAT-1 In Pathogenesis of Psoriasis in Egyptian Patients..

Abstract

Introduction:Psoriasis is a chronic, debilitating disease affecting 1-2% of the whole population. Aim of the study:We aimed to investigate the expression of LncRNA NEAT-1 in psoriasis patients and the possibility of using their serum level as a potential marker for the diagnosis of the disease.Subjects and Methods: 60 subjects were recruited from a dermatology outpatient clinic for this study and were divided into 2 groups: 40 psoriatic patients and 20 age-and sex-matched healthy control subjects.LncRNA NEAT-1 expression was detected by quantitative real-time polymerase chain reaction (qRT-PCR). Results:Our results showed a statistically significant increase in the expression of NEAT-1 in the serum of psoriatic patients compared to controls. ROC curve analysis revealed the diagnostic value of NEAT-1 as a predictor in differentiating between cases of psoriasis and controls (p-value<0.001, AUC=1). Conclusions:This study highlights the contribution of LncRNA NEAT-1 in the pathogenesis of psoriasis.The high expression of serum NEAT1 in psoriasis clarified its role as a potential marker for diagnosis and paved the way for the development of a potential therapy.