1976
DOI: 10.3171/jns.1976.45.1.0026
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Role of local hyperfibrinolysis in the etiology of chronic subdural hematoma

Abstract: ✓ The authors describe studies performed on material aspirated from chronic subdural hematomas. Patients were given 51Cr-labeled red cells prior to aspiration, and it was possible to demonstrate that the mean daily hemorrhage into the hematoma space amounted to 10.2% of its volume. Immunoelectrophoresis of the aspirated hematoma fluid by monospecific anti-human fibrinogen revealed the presence of fibrin and fibrinogen degradation products that, measured by hemagglutination-inhibition immunoassay techniques, va… Show more

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Cited by 200 publications
(90 citation statements)
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“…On the other hand, MVD in the outer membrane of CSDHs was similar to those described in tumors. 9) Therefore, the outer membrane of CSDH may be saturated with microvessels promoted by the extremely high levels of VEGF in the hematoma fluid and membrane. Such new vessels, with loose junctions between adjacent endothelial cells and the partial absence of basal membrane and pericytes, are abnormally permeable and fragile.…”
Section: Discussionmentioning
confidence: 99%
“…On the other hand, MVD in the outer membrane of CSDHs was similar to those described in tumors. 9) Therefore, the outer membrane of CSDH may be saturated with microvessels promoted by the extremely high levels of VEGF in the hematoma fluid and membrane. Such new vessels, with loose junctions between adjacent endothelial cells and the partial absence of basal membrane and pericytes, are abnormally permeable and fragile.…”
Section: Discussionmentioning
confidence: 99%
“…Inflammation may be an important element in the pathogenesis of CSH, 4) and eosinophils infiltrating the membrane of the hematoma may contribute to bleeding into the cavity. 3,9) Increased plasma levels of the inflammatory mediator platelet-activating factor (PAF) and anti-PAF immunoglobulin G levels are observed after head injury in patients with CSH but not in patients with other types of head injury or in normal subjects, 1) which suggests the involvement of PAF in the formation of CSH. Further, PAF concentrations are higher in acute than in chronic CSH, whereas PAF acetylhydrolase activity is lower in acute than in chronic CSH.…”
Section: Introductionmentioning
confidence: 99%
“…8) Repeated hemorrhaging from the outer membrane has been considered to be a causative factor of the chronic subdural hematoma. 6,21) Intravenous infusion of 51 Cr-labeled red blood cells in patients with chronic subdural hematoma resulted in the subsequent presence of labeled cells in the subdural fluid. 7) The presence of 51 Cr-labeled erythrocytes in the chronic subdural hematoma fluid confirms rebleeding from capillaries in the outer membrane as a major source of expansion in the chronic subdural hematoma.…”
Section: Discussionmentioning
confidence: 99%