Role of long non-coding RNAs and TGF-β signaling in the regulation of breast cancer pathogenesis and therapeutic targets

Hussen, Bashdar Mahmud; Hidayat, Hazha Jamal; Abdullah, Snur Rasool; Mohamadtahr, Sayran; Rasul, Mohammad Fatih; Samsami, Majid; Taheri, Mohammad

doi:10.1016/j.cyto.2023.156351

Cited by 4 publications

(1 citation statement)

References 135 publications

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“…TGF-β is a highly conserved family whose signaling is involved in different cellular processes such as cell growth, proliferation, migration and differentiation [97,98]. TGF-β signaling can either suppress or induce tumor progression, as it promotes cell cycle arrest and apoptosis in early BC stages, whereas in advanced stages, it favors cell motility, invasion and epithelial-to-mesenchymal transition (EMT) [99].…”

Section: Protein-and Mrna-mediated Regulation Of Signaling Pathways B...mentioning

confidence: 99%

NORAD-Regulated Signaling Pathways in Breast Cancer Progression

Capela,

Tavares-Marcos,

Estima-Arede

et al. 2024

Cancers

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Long non-coding RNA activated by DNA damage (NORAD) has recently been associated with pathologic mechanisms underlying cancer progression. Due to NORAD’s extended range of interacting partners, there has been contradictory data on its oncogenic or tumor suppressor roles in BC. This review will summarize the function of NORAD in different BC subtypes and how NORAD impacts crucial signaling pathways in this pathology. Through the preferential binding to pumilio (PUM) proteins PUM1 and PUM2, NORAD has been shown to be involved in the control of cell cycle, angiogenesis, mitosis, DNA replication and transcription and protein translation. More recently, NORAD has been associated with PUM-independent roles, accomplished by interacting with other ncRNAs, mRNAs and proteins. The intricate network of NORAD-mediated signaling pathways may provide insights into the potential design of novel unexplored strategies to overcome chemotherapy resistance in BC treatment.

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Section: Protein-and Mrna-mediated Regulation Of Signaling Pathways B...mentioning

confidence: 99%

NORAD-Regulated Signaling Pathways in Breast Cancer Progression

Capela,

Tavares-Marcos,

Estima-Arede

et al. 2024

Cancers

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Deciphering the landscape of triple negative breast cancer from microenvironment dynamics and molecular insights to biomarker analysis and therapeutic modalities

Tiwari,

Singh,

Sharma

et al. 2024

Medicinal Research Reviews

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Triple negative breast cancer (TNBC) displays a notable challenge in clinical oncology due to its invasive nature which is attributed to the absence of progesterone receptor (PR), estrogen receptor (ER), and human epidermal growth factor receptor (HER‐2). The heterogenous tumor microenvironment (TME) of TNBC is composed of diverse constituents that intricately interact to evade immune response and facilitate cancer progression and metastasis. Based on molecular gene expression, TNBC is classified into four molecular subtypes: basal‐like (BL1 and BL2), luminal androgen receptor (LAR), immunomodulatory (IM), and mesenchymal. TNBC is an aggressive histological variant with adverse prognosis and poor therapeutic response. The lack of response in most of the TNBC patients could be attributed to the heterogeneity of the disease, highlighting the need for more effective treatments and reliable prognostic biomarkers. Targeting certain signaling pathways and their components has emerged as a promising therapeutic strategy for improving patient outcomes. In this review, we have summarized the interactions among various components of the dynamic TME in TNBC and discussed the classification of its molecular subtypes. Moreover, the purpose of this review is to compile and provide an overview of the most recent data about recently discovered novel TNBC biomarkers and targeted therapeutics that have proven successful in treating metastatic TNBC. The emergence of novel therapeutic strategies such as chemoimmunotherapy, chimeric antigen receptor (CAR)‐T cells‐based immunotherapy, phytometabolites‐mediated natural therapy, photodynamic and photothermal approaches have made a significant positive impact and have paved the way for more effective interventions.

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Epigenetic regulation of TGF-β and vice versa in cancers – A review on recent developments

Naik,

Thakur

2024

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer

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Role of long non-coding RNAs and TGF-β signaling in the regulation of breast cancer pathogenesis and therapeutic targets

Cited by 4 publications

References 135 publications

NORAD-Regulated Signaling Pathways in Breast Cancer Progression

NORAD-Regulated Signaling Pathways in Breast Cancer Progression

Deciphering the landscape of triple negative breast cancer from microenvironment dynamics and molecular insights to biomarker analysis and therapeutic modalities

Epigenetic regulation of TGF-β and vice versa in cancers – A review on recent developments

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