Role of long non-coding RNAs in adipose tissue metabolism and associated pathologies

Corral, Ana; Alcalá, Martín; Durán-Ruiz, Ma Carmen; Arroba, Ana I.; Ponce-González, Jesús Gustavo; Todorčević, Marijana; Serra, Dolors; Calderón‐Domínguez, María; Herrero, Laura

doi:10.1016/j.bcp.2022.115305

Cited by 6 publications

(3 citation statements)

References 291 publications

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“…35 The discovery of the endocrine capacity of the BAT revealed an important regulatory role that spans beyond the classic view as a thermogenic organ. Through batokines, 8 lncRNA, 36 or extracellular vesicles, 37 BAT influences cardiac, hepatic, or brain function, among others. 10,11 Thus, other anatomical regions rich in brownlike adipocytes other than iBAT could participate in the regulation of the physiology of nearby organs.…”

Section: Discussionmentioning

confidence: 99%

Angiotensin II type 2 receptor as a novel activator of brown adipose tissue in obesity

et al. 2023

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The angiotensin II type 2 receptor (AT2R) exerts vasorelaxant, anti‐inflammatory, and antioxidant properties. In obesity, its activation counterbalances the adverse cardiovascular effects of angiotensin II mediated by the AT1R. Preliminary results indicate that it also promotes brown adipocyte differentiation in vitro. Our hypothesis is that AT2R activation could increase BAT mass and activity in obesity. Five‐week‐old male C57BL/6J mice were fed a standard or a high‐fat (HF) diet for 6 weeks. Half of the animals were treated with compound 21 (C21), a selective AT2R agonist, (1 mg/kg/day) in the drinking water. Electron transport chain (ETC), oxidative phosphorylation, and UCP1 proteins were measured in the interscapular BAT (iBAT) and thoracic perivascular adipose tissue (tPVAT) as well as inflammatory and oxidative parameters. Differentiation and oxygen consumption rate (OCR) in the presence of C21 was tested in brown preadipocytes. In vitro, C21‐differentiated brown adipocytes showed an AT2R‐dependent increase of differentiation markers (Ucp1, Cidea, Pparg) and increased basal and H+ leak‐linked OCR. In vivo, HF‐C21 mice showed increased iBAT mass compared to HF animals. Both their iBAT and tPVAT showed higher protein levels of the ETC protein complexes and UCP1, together with a reduction of inflammatory and oxidative markers. The activation of the AT2R increases BAT mass, mitochondrial activity, and reduces markers of tissue inflammation and oxidative stress in obesity. Therefore, insulin reduction and better vascular responses are achieved. Thus, the activation of the protective arm of the renin–angiotensin system arises as a promising tool in the treatment of obesity.

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Section: Discussionmentioning

confidence: 99%

Angiotensin II type 2 receptor as a novel activator of brown adipose tissue in obesity

et al. 2023

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“…In mammals, WAT is classified according to its location into subcutaneous WAT (scWAT) and visceral WAT (vWAT). 27 In humans, scWAT is located at the retro-orbital, facial, abdominal, subcutaneous, and gluteal areas while in rodents it is located at the suprascapular, anterior, inguinal, and gluteal areas. vWAT in humans is found at the retroperitoneal, perirenal, omental, and mesenteric areas while in rodents, it is found at the gonadal, perirenal, and retroperitoneal areas.…”

Section: At Functionsmentioning

confidence: 99%

“…Each fat depot has different metabolic functions as well as different molecular and physiological features. In mammals, WAT is classified according to its location into subcutaneous WAT (scWAT) and visceral WAT (vWAT) 27 . In humans, scWAT is located at the retro‐orbital, facial, abdominal, subcutaneous, and gluteal areas while in rodents it is located at the suprascapular, anterior, inguinal, and gluteal areas.…”

Section: At Functionsmentioning

confidence: 99%

Childhood obesity: Implications on adipose tissue dynamics and metabolic health

Palacios‐Marin,

Serra,

Jiménez‐Chillarón

et al. 2023

Obesity Reviews

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SummaryObesity is the leading risk factor for the development of type 2 diabetes and cardiovascular diseases. Childhood obesity represents an alarming health challenge because children with obesity are prone to remain with obesity throughout their life and have an increased morbidity and mortality risk. The ability of adipose tissue to store lipids and expand in size during excessive calorie intake is its most remarkable characteristic. Cellular and lipid turnovers determine adipose tissue size and are closely related with metabolic status. The mechanisms through which adipose tissue expands and how this affects systemic metabolic homeostasis are still poorly characterized. Furthermore, the mechanism through which increased adiposity extends from childhood to adulthood and its implications in metabolic health are in most part, still unknown. More studies on adipose tissue development in healthy and children with obesity are urgently needed. In the present review, we summarize the dynamics of white adipose tissue, from developmental origins to the mechanisms that allows it to grow and expand throughout lifetime and during obesity in children and in different mouse models used to address this largely unknown field. Specially, highlighting the role that excessive adiposity during the early life has on future's adipose tissue dynamics and individual's health.

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linc-ADAIN, a human adipose lincRNA, regulates adipogenesis by modulating KLF5 and IL-8 mRNA stability

O’Reilly,

Ho,

Coronel

et al. 2024

Cell Reports

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Role of long non-coding RNAs in adipose tissue metabolism and associated pathologies

Cited by 6 publications

References 291 publications

Angiotensin II type 2 receptor as a novel activator of brown adipose tissue in obesity

Angiotensin II type 2 receptor as a novel activator of brown adipose tissue in obesity

Childhood obesity: Implications on adipose tissue dynamics and metabolic health

linc-ADAIN, a human adipose lincRNA, regulates adipogenesis by modulating KLF5 and IL-8 mRNA stability

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