Role of lymphocytes in non-immune experimental inflammation

Abstract

The role of lymphocytes in acute, non-immune inflammation has been studied in rats. Using drug-induced leucopenia and cell transfer studies it was found that the reduced carrageenin paw oedema in leucopenic rats could be restored by a specific subclass of lymphocytes distinct from T and B lymphocytes. The inflammatory effect of these lymphocytes appears to be mediated by a factor, the release of which is inhibited by steroidal and non-steroidal anti-inflammatory drugs and antilymphocyte sera.

Noninvolvement of Histamine and Prostaglandins in the Dermatosis of Magnesium-Deficient Hairless Rats

“…Production and release of a pro-inflam matory factor by non-B, non-T lymphocytes in a nonimmune inflammation has been de scribed [Garcia-Leme, 1981]. However, this factor does not seem to be involved in Mg2+-deficient dermatosis, since indomethacin and aspirin inhibit the release of this factor.…”

Contribution of Lymphocytes in Edema Induced by Venom from the Wasp (Belonogaster fuscipennis)

“…It has been adequately documented in the literature observations which indicate that lymphocytes have the capability of secreting pro-inflammatory factors for the development of acute, non-immune inflammation (Garcia Leme, 1981;Garcia Leme et al, 1976, 1977, 1978. Following injury, materials formed or transformed at the affected area might gain access to the lymphatic vessels and stimualte lymphoid cells either to release proinflammatory factors or to migrate to the site of injury where they would exert proinflammatory activities (Garcia Leme, 1981;Bersani-Amado & Garcia Leme, 1982).…”

“…*P < 0.05 vs. initial counts. particular are thought to play a role in the development of acute inflammatory reaction (Garcia Leme, 1981). The study of venom-induced edema can be hampered by the appearance of haemorrhage, if the venom contained potent haemorrhagic principle(s) (Bjarnanson & Fox, 1989;Borkow & Gutierrez, 1993).…”

“…In addition, lymphocytes are thought to play a role in the development of acute inflammatory reactions. They are capable of releasing pro-inflammatory substances that are of importance for adequate response against injury (Garcia Leme, 1981;Garcia Leme et al, 1976;Bechara et al, 1976). Furthermore, surgical obtruction of the thoracic duct, with interruption of lymphocyte recirculation, is accompained by decreased lymphocyte counts in blood and reduced inflammatory reactions (Sudo & Garcia Leme, 1980).…”

Effect of a Lymphocyte-Derived Pro-Inflammatory Factor on Carrageenan Pleurisy in the Rat

“…Garcia Leme [1981] has produced strong evidence that lymphocytes, independent of previous sensitisa tion, release pro-inflammatory factor(s) needed for adequate host response to injury. Previously, Bechara et al [1976], using histological techniques have shown that this lymphocyte factor interferes with events leading to fluid exudation with no effect on the cellu lar response.…”