Role of macromolecules in the safety of use of body wash cosmetics

Iridoids from Cornus mas L. and their potential as innovative ingredients in cosmetics

“…The most potent irritant activity is ascribed to anionic surfactants which interact with proteins via ionic bonds. Nonionic and amphoteric washing agents exhibit no irritant effects because of weak hydrogen interactions with the surface protein 38- 42 . The results indicate that iridoids have no signifi cant impact on reducing the irritant activity of SLS and SLES.…”

Supercritical carbon dioxide blackcurrant seed extract as an anti-irritant additive for hand dishwashing liquids

“…These considerations can be analyzed in several aspects, including the effect on the skin of the hands and the surface of dishes during washing, impact on the natural environment or the possibility of HDL residues from improperly rinsed dish surfaces being transferred onto food and then into the human digestive system (1)(2)(3)(4). Although raw materials used for manufacturing products of this type meet relevant requirements, the most challenging problem is the selection of HDL composition, so that the finished products would have a high detergent activity on the one hand, and makes the smallest possible negative impact on the skin of the hands on the other (1)(2)(3)(4)(5). Since the detergent activity and the effect on hand skin are -in this case -conflicting goals, HDL formulations must always represent some sort of a compromise.…”

“…The monomers interact with the skin, frequently contributing to skin irritation. Moreover, surfactants play a role in the removal of lipids from the outer skin layer, causing dryness and impairment of skin function as a protective barrier preventing the transfer of physical and chemical agents inside (4)(5)(6).…”

“…The basic ingredients of HDLs are surfactants (1,(4)(5)(6). The compounds ensure appropriate detergent and foaming properties, and make it possible to obtain an appropriate viscosity of finished products.…”

“…The most common surfactants include alkyl aryl sulfonates, alkyl sulfonates, alkyl sulfates and alkyl ether sulfates. They are used due to their beneficial foaming properties, high washing power and easy modification of the viscosity of the product in which they are used (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13). Auxiliary surfactants used in HDLs include mainly nonionic compounds (fatty alcohol ethoxylates, alkanolamides, alkyl polyglucosides) and amphoteric compounds (alkylamidopropyl betaines) (7)(8)(9)(10)(11)(12)(13).…”